Engineered hydrogel platform for diabetic wound healing

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160379 - 160379

Published: Feb. 1, 2025

Language: Английский

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pH-responsive and self-adaptive injectable sodium alginate/carboxymethyl chitosan hydrogel accelerates infected wound healing by bacteriostasis and immunomodulation

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123322 - 123322

Published: Jan. 1, 2025

Language: Английский

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Effects of Astragalus polysaccharide on the physicochemical properties of heat-induced whey protein gels by simultaneous rheology and fourier transform infrared spectroscopy

Journal of Dairy Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Intelligent hydrogel-based dressings for treatment of chronic diabetic wounds

World Journal of Diabetes, Journal Year: 2025, Volume and Issue: 16(5)

Published: April 24, 2025

Diabetic wounds represent a significant challenge in the medical field, significantly impacting patient quality of life and imposing heavy burden on healthcare systems. Intelligent hydrogel dressings have attracted attention diabetic wound treatment due to their unique properties. This review systematically explores three main categories intelligent hydrogels (natural, synthetic, composite), dissecting composition, structure, mechanisms that enable responses. The crucial roles these maintaining moist environment, efficiently absorbing exudate, precisely delivering drugs are expounded. Moreover, application advantages combating bacteria infections, regulating inflammation immunity, promoting angiogenesis tissue regeneration, as well enabling real-time monitoring personalized treatment, explored depth. Additionally, we discuss future research directions prospects for precision medicine care, aiming inspire innovation provide comprehensive theoretical basis development next-generation dressings.

Language: Английский

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Mechanistic Advances in Hypoglycemic Effects of Natural Polysaccharides: Multi-Target Regulation of Glycometabolism and Gut Microbiota Crosstalk

Molecules, Journal Year: 2025, Volume and Issue: 30(9), P. 1980 - 1980

Published: April 29, 2025

Natural polysaccharides (NPs), as a class of bioactive macromolecules with multitarget synergistic regulatory potential, exhibit significant advantages in diabetes intervention. This review systematically summarizes the core hypoglycemic mechanisms NPs, covering structure-activity relationships, integration gut microbiota-metabolism-immunity axis, and regulation key signaling pathways. Studies demonstrate that molecular weight, branch complexity, chemical modifications NPs mediate their activity by influencing bioavailability target specificity. improve glucose metabolism through multiple pathways: activating insulin signaling, improving resistance (IR), enhancing glycogen synthesis, inhibiting gluconeogenesis, regulating microbiota homeostasis. Additionally, protect pancreatic β-cell function via nuclear factor E2-related 2 (Nrf2)/Antioxidant Response Element (ARE) antioxidant pathway Toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) anti-inflammatory pathway. Clinical application still requires overcoming challenges such resolving complex relationships dynamically integrating cross-organ signaling. Future research should focus on multi-omics technologies (e.g., metagenomics, metabolomics) organoid models to decipher action networks promote translation from basic clinical applications.

Language: Английский

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Cascade Regulation of Blood Clot Stabilization‐Cell Migration‐Osteogenic Differentiation by Hollow Hydrogels for Periodontal Bone Regeneration and Repair

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

Abstract Periodontal bone destruction caused by periodontitis presents a significant clinical challenge. Optimal regeneration of periodontal shall progress through three distinct physiological stages: 1) formation blood clot; 2) recruitment stem cells to the and 3) osteogenic differentiation cells. In this context, present study proposes hollow carboxymethyl chitosan (CMCS)/sodium alginate (SA)/CaCO 3 microparticles (CACC) hydrogel. Its utilizes temporal differences in cross‐linking between outer inner regions. The results indicate that structure CACC hydrogel enhances clot stability. Additionally, facilitates migration human‐derived ligament (PDLSCs) MC3T3‐E1 release calcium ions (Ca 2+ ). Furthermore, it supports both PDLSCs upregulating osteogenesis‐related proteins. conclusion, leveraging entanglement properties polymers, sequentially regulates critical stages is developed. Notably, effectively preserves clots, an often‐overlooked aspect repair, within its structure. This innovation encourages advancement biomaterials more closely mimic natural repair process.

Language: Английский

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Novel composite hydrogels prepared from carboxymethyl chitosan and polysaccharides extracted from Ononis natrix for controlled release of bioactive molecules

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 318, P. 144880 - 144880

Published: June 2, 2025

Language: Английский

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Anemarrhena asphodeloides fructan attenuates cigarette smoke-induced muscle atrophy by activating the Akt/mTOR pathway and inhibiting the ubiquitin-proteasome pathway

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 120116 - 120116

Published: June 1, 2025

Language: Английский

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