Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 120116 - 120116
Published: June 1, 2025
Language: Английский
Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 120116 - 120116
Published: June 1, 2025
Language: Английский
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160379 - 160379
Published: Feb. 1, 2025
Language: Английский
Citations
3Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123322 - 123322
Published: Jan. 1, 2025
Language: Английский
Citations
1Journal of Dairy Science, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0World Journal of Diabetes, Journal Year: 2025, Volume and Issue: 16(5)
Published: April 24, 2025
Diabetic wounds represent a significant challenge in the medical field, significantly impacting patient quality of life and imposing heavy burden on healthcare systems. Intelligent hydrogel dressings have attracted attention diabetic wound treatment due to their unique properties. This review systematically explores three main categories intelligent hydrogels (natural, synthetic, composite), dissecting composition, structure, mechanisms that enable responses. The crucial roles these maintaining moist environment, efficiently absorbing exudate, precisely delivering drugs are expounded. Moreover, application advantages combating bacteria infections, regulating inflammation immunity, promoting angiogenesis tissue regeneration, as well enabling real-time monitoring personalized treatment, explored depth. Additionally, we discuss future research directions prospects for precision medicine care, aiming inspire innovation provide comprehensive theoretical basis development next-generation dressings.
Language: Английский
Citations
0Molecules, Journal Year: 2025, Volume and Issue: 30(9), P. 1980 - 1980
Published: April 29, 2025
Natural polysaccharides (NPs), as a class of bioactive macromolecules with multitarget synergistic regulatory potential, exhibit significant advantages in diabetes intervention. This review systematically summarizes the core hypoglycemic mechanisms NPs, covering structure-activity relationships, integration gut microbiota-metabolism-immunity axis, and regulation key signaling pathways. Studies demonstrate that molecular weight, branch complexity, chemical modifications NPs mediate their activity by influencing bioavailability target specificity. improve glucose metabolism through multiple pathways: activating insulin signaling, improving resistance (IR), enhancing glycogen synthesis, inhibiting gluconeogenesis, regulating microbiota homeostasis. Additionally, protect pancreatic β-cell function via nuclear factor E2-related 2 (Nrf2)/Antioxidant Response Element (ARE) antioxidant pathway Toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) anti-inflammatory pathway. Clinical application still requires overcoming challenges such resolving complex relationships dynamically integrating cross-organ signaling. Future research should focus on multi-omics technologies (e.g., metagenomics, metabolomics) organoid models to decipher action networks promote translation from basic clinical applications.
Language: Английский
Citations
0Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: May 13, 2025
Abstract Periodontal bone destruction caused by periodontitis presents a significant clinical challenge. Optimal regeneration of periodontal shall progress through three distinct physiological stages: 1) formation blood clot; 2) recruitment stem cells to the and 3) osteogenic differentiation cells. In this context, present study proposes hollow carboxymethyl chitosan (CMCS)/sodium alginate (SA)/CaCO 3 microparticles (CACC) hydrogel. Its utilizes temporal differences in cross‐linking between outer inner regions. The results indicate that structure CACC hydrogel enhances clot stability. Additionally, facilitates migration human‐derived ligament (PDLSCs) MC3T3‐E1 release calcium ions (Ca 2+ ). Furthermore, it supports both PDLSCs upregulating osteogenesis‐related proteins. conclusion, leveraging entanglement properties polymers, sequentially regulates critical stages is developed. Notably, effectively preserves clots, an often‐overlooked aspect repair, within its structure. This innovation encourages advancement biomaterials more closely mimic natural repair process.
Language: Английский
Citations
0International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 318, P. 144880 - 144880
Published: June 2, 2025
Language: Английский
Citations
0Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 120116 - 120116
Published: June 1, 2025
Language: Английский
Citations
0