European Journal of Heart Failure, Journal Year: 2023, Volume and Issue: 25(11), P. 1887 - 1890
Published: Nov. 1, 2023
Language: Английский
European Journal of Heart Failure, Journal Year: 2023, Volume and Issue: 25(11), P. 1887 - 1890
Published: Nov. 1, 2023
Language: Английский
Published: Feb. 6, 2024
In this thesis, we first focused on the prognostic impact of mitral regurgitation (MR) across different heart failure (HF) scenarios: chronic worsening HF, acute HF and advanced HF. BIOSTAT-CHF study HELP-HF registry, significant MR was independently associated with worse outcomes among patients respectively. However, in RELAX-AHF-2 trial, moderate-severe had a primary composite endpoint (180-day cardiovascular death or rehospitalization for renal failure) at univariable analyses after adjustment age sex, but not extensive multivariable adjustment. Subsequently, explored pathophysiological mechanisms underlying presence BIOSTAT-CHF, differentially expressed circulating biomarkers without were investigated. A distinct expression profile identified MR, differently versus related to congestion, mineral metabolism, lipid metabolism cachexia, oxidative stress. Finally, determinants changes optimization medical therapy severity dynamically changed up-titration, strong independent impact. Of note, higher ACEi/ARB up-titration left ventricular ejection fraction ≥50% likelihood improvement optimization.
Language: Английский
Citations
0Journal of Cardiac Failure, Journal Year: 2024, Volume and Issue: 30(4), P. 538 - 540
Published: Feb. 21, 2024
Language: Английский
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Published: Dec. 27, 2023
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Language: Английский
Citations
1European Journal of Heart Failure, Journal Year: 2023, Volume and Issue: 25(12), P. 2099 - 2101
Published: Dec. 1, 2023
Language: Английский
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1European Journal of Heart Failure, Journal Year: 2024, Volume and Issue: 26(4), P. 785 - 787
Published: April 1, 2024
Language: Английский
Citations
0European Journal of Heart Failure, Journal Year: 2023, Volume and Issue: 25(11), P. 1887 - 1890
Published: Nov. 1, 2023
Language: Английский
Citations
0