Visceral obesity and HFpEF: targets and therapeutic opportunities
Yilin Li,
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Zhuofeng Lin,
No information about this author
Yulin Li
No information about this author
et al.
Trends in Pharmacological Sciences,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 1, 2025
Language: Английский
Insights into the role of obesity in Heart Failure with Preserved Ejection Fraction pathophysiology and management
Canadian Journal of Cardiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 1, 2025
Language: Английский
The impact of lifestyle‐based weight loss in older adults with obesity on muscle and bone health: a balancing act
Obesity,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 10, 2025
Abstract
Despite
adverse
metabolic
and
functional
consequences
of
obesity
(BMI
≥30
kg/m
2
),
clinical
recommendations
for
weight
loss
(WL)
in
older
adults
(65+
years)
with
remain
controversial.
Reluctance
stems
partly
from
epidemiologic
data
demonstrating
musculoskeletal
tissue
WL
increased
risk
disability
osteoporotic
fracture.
Randomized
controlled
trials
complement
extend
knowledge
this
area
showing:
(1)
lifestyle‐based
interventions
often
yield
clinically
meaningful
(~8%–10%)
adults;
(2)
lean
mass
is
significant,
although
fat
preferential
physical
performance
improved,
particularly
when
combined
aerobic
resistance
training
(RT);
(3)
bone
also
some
evidence
that
RT
can
attenuate
WL‐associated
loss;
(4)
regain
after
intervention
cessation
common,
yet
gains
appear
to
be
maintained.
Best
practices
treating
include
comprehensive
assessment
baseline
health;
patient‐centered
goal
setting;
moderate
(i.e.,
−500
kcal/day)
caloric
restriction
ensuring
protein
(1–1.2
g/kg/day),
calcium
(1000–1200
mg/day),
vitamin
D
(800–1000
IU/day)
needs
are
met;
incorporation
(≥2
days/week)
moderate‐intensity
weight‐bearing
(≥150
min/week);
delivery
care
by
a
multidisciplinary
team.
image
Language: Английский
Aerobic, resistance, and specialized exercise training in heart failure with preserved ejection fraction: A state-of-the-art review
Saeid Mirzai,
No information about this author
Uttsav Sandesara,
No information about this author
Mark J. Haykowsky
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et al.
Heart Failure Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 15, 2025
Language: Английский
Dietary Interventions in Heart Failure With Preserved Ejection Fraction
JACC Advances,
Journal Year:
2024,
Volume and Issue:
4(1), P. 101465 - 101465
Published: Dec. 17, 2024
Language: Английский
Assessing Static Balance, Balance Confidence, and Fall Rate in Patients with Heart Failure and Preserved Ejection Fraction: A Comprehensive Analysis
Sensors,
Journal Year:
2024,
Volume and Issue:
24(19), P. 6423 - 6423
Published: Oct. 4, 2024
Chronic
heart
failure
(CHF)
is
a
complex
clinical
syndrome,
associated
with
frailty,
higher
fall
rates,
and
frequent
hospitalizations.
Heart
Failure
(HF)
preserved
ejection
fraction
(HFpEF)
defined
as
condition
where
patient
HF
have
diagnosis
of
left
ventricular
(LVEF)
≥
50%.
The
risk
HFpEF
increases
age
related
to
non-cardiovascular
mortality.
aim
this
study
was
evaluate
static
balance
examine
the
effect
task
difficulty
on
discriminating
power
control
between
patients
(Patients
HFpEF)
their
healthy
controls.
Moreover,
associations
parameters,
confidence,
falls,
lean
muscle
mass,
strength
were
assessed.
Seventy
two
(mean
age:
66.0
±
11.6
years)
seventy
age-
gender-matched
individuals
65.3
9.5
participated
in
study.
Participants
underwent
30
s
bilateral
stance
(BS)
test
20
Tandem-Romberg
(TRS)
force
platform,
evaluating
Range
Standard
Deviation
Center
Pressure
(COP)
displacement
parameters
both
axes.
Balance
confidence
evaluated
by
Activities-Specific
Confidence
(ABC)
Scale,
number
falls
during
last
year
recorded.
Lower
limb
measured
using
an
isokinetic
dynamometer,
isometric
leg
strength,
Sit-to-Stand
test.
Bioelectrical
impedance
analysis
conducted
assess
fat
mass
index,
lean%.
Patients
presented
lower
BS
TRS
compared
controls
(p
<
0.05),
21.5%
incidence
72.9%
0.05).
better
descriptor
between-group
difference.
Furthermore,
balance,
assessed
controlled
lab
conditions,
found
little
if
no
relationship
confidence.
Although
correlation
noted
rate
age,
fat.
Language: Английский
Validation of Segmental Bioelectrical Impedance Analysis Compared with Dual Energy X-Ray Absorptiometry to Measure Body Composition in Patients with Obesity-related Heart Failure with Preserved Ejection Fraction
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 23, 2024
Background.
Appendicular
lean
mass
index
(ALMI),
a
term
used
to
describe
appendicular
soft
tissue
measured
by
dual-energy
X-ray
absorptiometry
(DXA),
is
major
determinant
of
cardiorespiratory
fitness
in
patients
with
obesity-related
heart
failure
preserved
ejection
fraction
(HFpEF).
Moreover,
ALMI
can
be
diagnose
sarcopenia
and
sarcopenic
obesity
this
population.
DXA
reference
standard
for
assessing
body
composition,
however,
segmental
single-frequency
bioelectrical
impedance
analysis
(SF-BIA)
could
offer
more
accessible,
portable,
cost-effective,
radiation-free
alternative.
To
validate
SF-BIA
composition
HFpEF
obesity,
focus
on
ALMI.
Methods.
We
analyzed
62
consecutive
euvolemic
persistent
(83.8%
female,
60.8±
2.8
years
age).
both
measure
fat
(AFMI),
(FM),
fat-free
(FFM)
kg
as
%
weight,
FM
index,
FFM
index.
Correlations
were
assessed
using
Pearson?s
coefficients
Bland-Altman
plots,
while
linear
regression
was
performed
evaluate
proportional
bias.
Results.
Strong,
statistically
significant
correlations
found
between
BIA
(r=0.897),
AFMI
(r=0.864),
(r=0.968),
FM%
(r=0.867),
(r=0.954),
FFM%
(r=0.852),
(r=0.97),
(r=0.88)
(all
p<0.001).
The
demonstrated
agreement
methods
indicated
no
bias
all
parameters,
except
AFMI.
Conclusions.
Segmental
SF-BIA-measured
shows
strong
correlations,
appropriate
agreements,
compared
DXA.
Considering
the
central
role
particularly
HFpEF,
when
not
readily
available
or
contraindicated,
should
considered
Language: Английский