Journal of the American Society for Mass Spectrometry,
Journal Year:
2024,
Volume and Issue:
35(3), P. 622 - 630
Published: Feb. 8, 2024
Cyclodextrins
(CDs)
exhibit
versatile
self-assembly
properties
due
to
their
hydrophilic
and
hydrophobic
components,
with
applications
such
as
drug
delivery
selective
binding.
While
research
on
CD
is
extensive,
limited
studies
have
explored
aggregation
behavior,
particularly
in
interactions
small
ionic
guests.
The
present
work
investigates
the
structure
of
β-CD
tetramers
aggregated
alkali
metal
chloride
clusters
using
ion
mobility
spectrometry–mass
spectrometry
(IMS-MS).
results
revealed
that
diverse
structures
emerge
tetramer
depending
cluster
size.
Notably,
doubly
charged
exhibits
distinct
trends
specific
numbers
MCl
for
Na+
K+
ions.
After
initially
adopting
a
bucket-wheel
two
internal
cations,
transforms
into
new
isomer
tetrahedral
configuration
upon
addition.
formation
closely
linked
filling
cavity
volume
interactions,
which
possibly
compensate
weakened
hydrogen
bonds
between
CDs.
Theoretical
calculations
further
support
structures,
showing
well-matched
collision
cross-section
(CCS)
values
compared
experimental
CCS
values.
This
study
highlights
role
potential
templates,
leading
novel
assemblies.
Advanced NanoBiomed Research,
Journal Year:
2023,
Volume and Issue:
3(12)
Published: Nov. 21, 2023
Despite
remarkable
advances
in
understanding
the
mechanisms
underlying
inflammation,
currently
available
anti‐inflammatory
therapies
have
many
limitations,
such
as
poor
efficacies,
low
selectivity,
and
severe
adverse
effects.
Bioactive
materials
with
intrinsically
activities
emerged
promising
drug
candidates
for
treatment
of
inflammatory
disorders.
Among
them,
nanotherapies
based
on
bioactive
cyclodextrin
(CD)
attracted
much
attention,
owing
to
their
multiple
advantages,
including
broad
availability,
well‐controlled
structures,
easy
functionalization,
good
processibility,
high
cost‐effectiveness,
excellent
biocompatibility.
This
review
provides
a
comprehensive
overview
recent
advancements
development
applications
nanoparticles
(NPs)
CD
materials,
special
focus
reactive
oxygen
species‐scavenging
NPs
capable
regulating
cell
recruitment
activation.
In
addition,
these
different
acute/chronic
diseases
are
highlighted.
Furthermore,
major
challenges
clinical
translation
new
generation
derived
from
discussed.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(12), P. 1721 - 1721
Published: Dec. 12, 2023
This
review
summarizes
the
recent
findings
on
development
of
different
types
single
and
multitarget
nanoparticles
for
disease
detection
drug
delivery
to
brain,
focusing
promising
active
principles
encapsulated
nanoparticle
surface
modification
functionalization.
Functionalized
have
emerged
as
tools
diagnosis
treatment
brain
disorders,
offering
a
novel
approach
addressing
complex
neurological
challenges.
They
can
act
vehicles,
transporting
one
or
multiple
therapeutic
agents
across
blood-brain
barrier
precisely
releasing
them
at
site
action.
In
diagnostics,
functionalized
serve
highly
sensitive
contrast
imaging
techniques
such
magnetic
resonance
computed
tomography
scans.
By
attaching
targeting
ligands
nanoparticles,
they
selectively
accumulate
in
affected
areas
enhancing
accuracy
detection.
enables
early
monitoring
conditions
like
Alzheimer's
Parkinson's
diseases.
While
field
is
still
evolving,
represent
path
advancing
our
ability
diagnose
treat
disorders
with
greater
precision,
reduced
invasiveness,
improved
outcomes.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(39), P. 35470 - 35498
Published: Sept. 22, 2023
In
the
past
few
decades,
advancements
in
protein
engineering,
biotechnology,
and
structural
biochemistry
have
resulted
discovery
of
various
techniques
that
enhanced
production
yield
proteins,
targetability,
circulating
half-life,
product
purity,
functionality
proteins
peptides.
As
a
result,
utilization
peptides
has
increased
treatment
many
conditions,
including
ocular
diseases.
Ocular
delivery
large
molecules
poses
several
challenges
due
to
their
high
molecular
weight,
hydrophilicity,
unstable
nature,
poor
permeation
through
cellular
enzymatic
barriers.
The
use
novel
strategies
for
delivering
such
as
glycoengineering,
PEGylation,
Fc-fusion,
chitosan
nanoparticles,
liposomes
improved
efficacy,
safety,
stability,
which
consequently
expanded
therapeutic
potential
proteins.
This
review
article
highlights
are
useful
disorders,
eye,
enhance
bioavailability
using
approaches.
addition,
futuristic
approaches
will
assist
were
also
discussed.
Journal of the American Society for Mass Spectrometry,
Journal Year:
2024,
Volume and Issue:
35(3), P. 622 - 630
Published: Feb. 8, 2024
Cyclodextrins
(CDs)
exhibit
versatile
self-assembly
properties
due
to
their
hydrophilic
and
hydrophobic
components,
with
applications
such
as
drug
delivery
selective
binding.
While
research
on
CD
is
extensive,
limited
studies
have
explored
aggregation
behavior,
particularly
in
interactions
small
ionic
guests.
The
present
work
investigates
the
structure
of
β-CD
tetramers
aggregated
alkali
metal
chloride
clusters
using
ion
mobility
spectrometry–mass
spectrometry
(IMS-MS).
results
revealed
that
diverse
structures
emerge
tetramer
depending
cluster
size.
Notably,
doubly
charged
exhibits
distinct
trends
specific
numbers
MCl
for
Na+
K+
ions.
After
initially
adopting
a
bucket-wheel
two
internal
cations,
transforms
into
new
isomer
tetrahedral
configuration
upon
addition.
formation
closely
linked
filling
cavity
volume
interactions,
which
possibly
compensate
weakened
hydrogen
bonds
between
CDs.
Theoretical
calculations
further
support
structures,
showing
well-matched
collision
cross-section
(CCS)
values
compared
experimental
CCS
values.
This
study
highlights
role
potential
templates,
leading
novel
assemblies.
