Chitosan and its derivatives: A novel approach to gut microbiota modulation and immune system enhancement
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
289, P. 138633 - 138633
Published: Dec. 13, 2024
Language: Английский
Advances in bio-polymer coatings for probiotic microencapsulation: chitosan and beyond for enhanced stability and controlled release
Designed Monomers & Polymers,
Journal Year:
2024,
Volume and Issue:
28(1), P. 1 - 34
Published: Dec. 31, 2024
This
review
paper
analyzes
recent
advancements
in
bio-polymer
coatings
for
probiotic
microencapsulation,
with
a
particular
emphasis
on
chitosan
and
its
synergistic
combinations
other
materials.
Probiotic
microencapsulation
is
essential
protecting
probiotics
from
environmental
stresses,
enhancing
their
stability,
ensuring
effective
delivery
to
the
gut.
The
begins
an
overview
of
highlighting
significance
safeguarding
through
processing,
storage,
gastrointestinal
transit.
Advances
chitosan-based
encapsulation
are
explored,
including
integration
bio-polymers
such
as
alginate,
gelatin,
pectin,
well
application
nanotechnology
innovative
techniques
like
spray
drying
layer-by-layer
assembly.
Detailed
mechanistic
insights
integrated,
illustrating
how
influences
gut
microbiota
by
promoting
beneficial
bacteria
suppressing
pathogens,
thus
role
prebiotic
or
synbiotic.
Furthermore,
delves
into
chitosan's
immunomodulatory
effects,
particularly
context
inflammatory
bowel
disease
(IBD)
autoimmune
diseases,
describing
immune
signaling
pathways
influenced
linking
changes
improvements
systemic
immunity.
Recent
clinical
trials
human
studies
assessing
efficacy
chitosan-coated
presented,
alongside
discussion
practical
applications
comparison
vitro
vivo
findings
highlight
real-world
relevance.
sustainability
sources
impact
addressed,
along
novel
concept
gut-brain
axis.
Finally,
emphasizes
future
research
needs,
development
personalized
therapies
exploration
techniques.
Language: Английский
Engineering Polymers: From Biodegradable Platforms to Intelligent Drug Carriers
Jasleen Kaur Minhas,
No information about this author
V. D. Aher,
No information about this author
Sushmitha Bujji
No information about this author
et al.
Polymer-Plastics Technology and Materials,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 27
Published: April 4, 2025
Language: Английский
Chitosan-incorporated Bioceramic-based Nanomaterials for Localized Release of Therapeutics and Bone Regeneration: An Overview of Recent Advances and Progresses
Current Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
28(15), P. 1190 - 1214
Published: May 15, 2024
Abstract:
The
usage
of
nanoparticles
in
tissue
engineering
applications
has
increased
significantly
the
last
several
years.
Functional
tissues
are
developed
by
regulating
cell
proliferation,
differentiation,
and
migration
on
nanostructured
scaffolds
containing
cells.
These
provide
an
environment
that
is
more
structurally
supportive
than
microarchitecture
natural
bone.
Given
its
exceptional
properties,
such
as
osteogenic
potential,
biocompatibility,
biodegradability,
chitosan
a
good
promising
biomaterial.
Unfortunately,
chitosan's
low
mechanical
strength
makes
it
unsuitable
for
load-bearing
applications.
By
mixing
with
other
biomaterials,
this
drawback
might
be
mitigated.
Bone
uses
both
bioresorbable
materials
like
tricalcium
phosphate
bioactive
hydroxyapatite
bioglass.
Alumina
titanium
examples
bioinert
part
these
bioceramics.
When
produced
at
nanoscale
scales,
have
larger
surface
area
better
adhesion.
This
review
paper
will
go
into
great
detail
bioinert,
bioresorbable,
nanoceramics-reinforced
bone
engineering.
Language: Английский
Antioxidants in Inflammatory Diseases
Sayed Mohammed Firdous,
No information about this author
Sourav Pal,
No information about this author
Subhajit Mandal
No information about this author
et al.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
unknown, P. 83 - 126
Published: Nov. 17, 2024
Damage
to
tissues
and
abnormal
function
of
organs
are
hallmarks
inflammatory
disorders,
which
characterized
by
an
overactive
inadequately
controlled
immune
response.
Inflammation
chronic
diseases
can
result
from
microbial
infections,
tissue
damage,
autoimmune
dysregulation.
These
stimuli
trigger
macrophages
neutrophils,
releasing
ROS
RNS.
ROS/RNS
overwhelm
the
body's
antioxidant
defenses,
causing
oxidative
assault
signaling
cascades.
NF-кβ
AP-1
activate
amid
assault.
transcription
factors
regulate
expression
pro-inflammatory
genes
that
create
cytokines
(TNF,
ILs),
chemokines,
adhesion
molecules,
enhance
inflammation
recruit
cells
damaged
areas.
Antioxidants
oversight
several
They're
able
block
production
pro-
reducing
activation.
Crucial
MAPK
pathways
like
ERK,
JNK,
p38
be
modulated
antioxidants.
decrease
mediator
synthesis
because
they
interfere
with
these
pathways.
Directly
scavenging
neutralizing
is
how
antioxidants
do
their
job.
Scavenging
protects
lipids,
proteins,
DNA
against
damage.
SOD,
catalase,
glutathione
peroxidase,
body-produced
enzymes.
Thus,
increasing
enzyme
activity
strengthens
cells'
defenses.
induce
anti-inflammatory
phenotype
in
T
cells.
They
capable
shifting
M1
M2.
M2
aid
repair
immunomodulation.
also
promote
formation
regulatory
cells,
system
inhibiting
other
In
conclusion,
this
abstract
emphasizes
crucial
role
potential
as
therapeutic
agents.
Language: Английский
Multifaceted therapeutic approach via thiazolidinedione-infused magnolol in chitosan nanoparticles targeting hyperlipidemia and oxidative stress in gestational diabetes mellitus in experimental mice
Rui Li
No information about this author
Naunyn-Schmiedeberg s Archives of Pharmacology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 12, 2024
Language: Английский