Synthesis of Functional Pectin‐Based Hydrogels via Thiol‐Maleimide Click Reaction for Enhanced Drug Encapsulation and Release

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

ABSTRACT This work describes the synthesis and characterization of a novel hydrogel system based on pectin (PT) functionalized with thiol maleimide groups cross‐linked by thiol‐maleimide click chemistry. Thiolated PT (PT‐SH) maleimide‐modified (PT‐Ma) precursors were synthesized carbodiimide‐mediated amidation confirmed elemental analysis, FTIR, 1H NMR spectroscopy. The resulting exhibited gelation efficiency over 80%, swelling degrees ranging from 44% to 80% depending cross‐linking density, pH‐sensitive behavior maximum at pH 8. demonstrated high mechanical stability, compressive strengths 20.8–33.2 kPa, increasing density. As model drug, ibuprofen was encapsulated efficiencies up 337 mg/g released in controlled fashion. In vitro release studies showed slower acidic environments, which ranged 22% 53% within 6–10 h, faster slightly alkaline environment, consistent profile hydrogel. Such properties underline hydrogel's potential for sustained drug delivery. Pectin hydrogels, upon cross‐linking, are hereby presented be strong platform biomedical applications properties, behavior, performance

Language: Английский

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Anthocyanin-rich jaboticaba fruit: Natural source of bioactive and coloring ingredients for nutraceutical food applications

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 153, P. 104744 - 104744

Published: Oct. 9, 2024

Language: Английский

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