Chemical Biology & Drug Design,
Journal Year:
2023,
Volume and Issue:
103(1)
Published: Nov. 2, 2023
Abstract
Breast
cancer
is
a
common
and
deadly
disease,
so
there
constant
need
for
research
to
find
efficient
targets
therapeutic
approaches.
can
be
classified
on
molecular
histological
base.
divided
into
ER
(estrogen
receptor)‐positive
ER‐negative,
HER2
(human
epidermal
growth
factor
receptor2)‐positive
HER2‐negative
subtypes
based
the
presence
of
specific
biomarkers.
Targeting
hormone
receptors,
such
as
HER2,
progesterone
receptor
(PR),
ER,
very
significant
plays
vital
role
in
onset
progression
breast
cancer.
Endocrine
treatments
HER2‐targeted
drugs
are
examples
targeted
therapies
now
being
used
against
these
receptors.
Emerging
immune‐based
medicines
with
promising
outcomes
treatment
include
immune
checkpoint
inhibitors,
vaccines,
adoptive
T‐cell
therapy.
It
also
explored
how
cells
tumor
microenvironment
affect
development
response.
The
major
biochemical
pathways,
signaling
cascades,
DNA
repair
mechanisms
that
involved
cancer,
PI3K/AKT/mTOR
system,
MAPK
pathway,
others.
These
pathways
intended
inhibited
by
variety
drugs,
which
then
delivered
goal
restoring
normal
cellular
function.
This
review
aims
shed
light
types
summarization
different
approaches
target
tailored
better
patient
outcomes.
Turkish Journal of Biochemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 22, 2025
Abstract
Objectives
Although
many
synthetic
anticancer
drugs
are
available,
a
significant
proportion
of
human
therapeutics
in
the
armamentarium
derived
from
natural
products.
The
aim
this
study
to
examine
effects
compounds
against
non-small
cell
lung
cancer
(NSCLC)
and
breast
cancer,
which
remain
among
world’s
greatest
obstacles.
Methods
Coronilla
orientalis
MILLER
(CO)
was
collected
Erzincan,
Türkiye,
prepared,
extracted
with
70
%
ethanol.
CO
then
tested
A549
NSCLC
MCF-7
cells
using
MTT
assay.
To
explore
its
potential
mechanism,
apoptotic
kinase
inhibitory
were
investigated
Annexin
V/ethidium
homodimer
III
staining
assay
ADP-Glo
assay,
respectively.
Molecular
docking
studies
also
performed
for
several
major
components
ATP
binding
site
EGFR.
Results
results
showed
that
CO,
IC
50
values
2.37
±
0.59
μg/mL
7.60
1.18
μg/mL,
exhibited
activity
cells,
selectively
cytotoxic
between
Jurkat
PBMCs
(healthy).
CO-treated
found
undergo
apoptosis
inhibit
revealed
interaction
some
defined
key
residues
Conclusions
Taken
together,
research
has
shown
great
deal
as
an
inhibitor
function
warrants
further
investigation.
Chemical Biology & Drug Design,
Journal Year:
2023,
Volume and Issue:
103(1)
Published: Nov. 2, 2023
Abstract
Breast
cancer
is
a
common
and
deadly
disease,
so
there
constant
need
for
research
to
find
efficient
targets
therapeutic
approaches.
can
be
classified
on
molecular
histological
base.
divided
into
ER
(estrogen
receptor)‐positive
ER‐negative,
HER2
(human
epidermal
growth
factor
receptor2)‐positive
HER2‐negative
subtypes
based
the
presence
of
specific
biomarkers.
Targeting
hormone
receptors,
such
as
HER2,
progesterone
receptor
(PR),
ER,
very
significant
plays
vital
role
in
onset
progression
breast
cancer.
Endocrine
treatments
HER2‐targeted
drugs
are
examples
targeted
therapies
now
being
used
against
these
receptors.
Emerging
immune‐based
medicines
with
promising
outcomes
treatment
include
immune
checkpoint
inhibitors,
vaccines,
adoptive
T‐cell
therapy.
It
also
explored
how
cells
tumor
microenvironment
affect
development
response.
The
major
biochemical
pathways,
signaling
cascades,
DNA
repair
mechanisms
that
involved
cancer,
PI3K/AKT/mTOR
system,
MAPK
pathway,
others.
These
pathways
intended
inhibited
by
variety
drugs,
which
then
delivered
goal
restoring
normal
cellular
function.
This
review
aims
shed
light
types
summarization
different
approaches
target
tailored
better
patient
outcomes.
