An overview of the therapeutic potential of understudied lichen species for novel drug discovery DOI Creative Commons

Aswathy Venugopal,

Stephey Glaudline,

David Paul Raj

et al.

Journal of Applied and Natural Science, Journal Year: 2024, Volume and Issue: 16(4), P. 1516 - 1529

Published: Dec. 20, 2024

Due to the emergence of new diseases, drug discovery is an ever-exciting field science. Researchers have shifted their focus from chemical-based medicines drugs natural origin and structural synthetic analogues solve problem developing antibiotic resistance detrimental impacts existing chemical medications. Lichens are still one least explored sources for discovery. These slow-growing forms a rich source some exceptional secondary metabolites known collectively as lichenochemicals. The significant proportion these lichenochemicals bioactive compounds with multiple pharmacological properties, including antimicrobial, anticancer, free radical scavenging, anti-inflammatory, antidiabetic neuroprotective abilities also high in nutritional values, making this uncanny combination algae fungi, together metabolites, so well renowned traditional indigenous medicine. Although only oral knowledge was available about them earlier, studies over last few decades isolated identified unique medicinal lichen biology most interesting promising areas research. More than half species phytochemicals yet be explored. However, lichen-derived vitamin D3 vegan D3. Likewise, shown that can significantly reduce developed by microorganisms. Advanced techniques identification isolation, combined bioinformatics, predictive software, databases, greatly aided understanding chemistry. This review summarizes use lichens highlight on recent breakthroughs biology.

Language: Английский

Uncovering the Anticancer Potential of Lichen Secondary Metabolites DOI Creative Commons

Patrik Šimko,

Terézia Kisková

Journal of Analytical Oncology, Journal Year: 2022, Volume and Issue: 11, P. 70 - 78

Published: Dec. 14, 2022

Lichens produce a plethora of primary and secondary metabolites. Secondary metabolites have several biological functions that can be used for human health. Recent studies described their antioxidant, anti-inflammatory, antimycotic, antibiotic/antiviral activities. However, attention has mainly been focused on antiproliferative, cytotoxic, anticancer effects. Because there are many publications describing the molecular mechanisms leading to effects lichen metabolites, aim this review is summarize results from current research with main emphasis atranorin, usnic gyrophoric acid.

Language: Английский

Citations

4
Evaluation of the Antifungal and Antiproliferative Properties of the Lichen Roccella tinctoria DC. Extracts and Main Components DOI Creative Commons
Claudio Frezza,

Dalia Rosa Fraioli,

Francesca Conti

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(3), P. 331 - 331

Published: Feb. 27, 2024

In this work, phytochemical analysis on different extracts of Roccella tinctoria DC. was reported using techniques with respect to the past. Twenty volatile and three non-volatile compounds were identified, some which found in species for first time. The methanolic their components then evaluated antitumor effects cancerous A549 Mz-ChA-1 cells tolerability non-cancerous BEAS-2B H69 cells, showing IC50 values from 94.6 µg/mL 416.4 µg/mL, general. same also tested antifungal Candida albicans, only compound 2 being active, an MIC50 value 87 µg/mL. addition, they anti-Candida adhesion activity, biofilm formation, mature inhibition, efficacy percentages generally above 50% but not all them. Lastly, DF3 extract 1–2 vivo according Galleria mellonella survival assay, positive mortality rates at concentrations. All these biological assays conducted Comparisons other lichens presented discussed.

Language: Английский

Citations

0
Microbial Multispecies Symbiosis: A Panomics View DOI
Amit Gupta, Ashish P. Singh, Palak Rana

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Unveiling the therapeutic potential of Lobaria extract and its depsides/depsidones in combatting Aβ42 peptides aggregation and neurotoxicity in Alzheimer’s disease DOI Creative Commons
Meixia Yang, C. C. Yan,

Dusadee Ospondpant

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 13, 2024

Background: The development of effective inhibitors that can inhibit amyloid β (A ) peptides aggregation and promote neurite outgrowth is crucial for the possible treatment Alzheimer’s disease (AD). Lobaria (Schreb.) Hoffm., a traditional Chinese medicine used in Himalaya region inflammatory diseases, contains depsides/depsidones (DEPs) such as gyrophoric acid, norstictic stictic acid known their anti-cancer anti-inflammation properties. Methods: extracts were analyzed using HPLC to identify DEPs establish standards. inhibitory effects on A 42 fibrillization depolymerization assessed various approaches with biophysical cellular methods. neuroprotective activity its aganist -mediated cytotoxicity was also evaluated. Results: Norstictic found water extract, while norstictic, stictic, detected ethanol extract . Both extracts, effectively inhibited fibrillation disaggregate mature fibrils. Notably, showed superior effect compared being most DEPs. Additionally, herbal extract-treated species significantly protected neuronal cells from 42-induced cell damage promoted outgrowth. Conclusion: This study first investigate AD. Given commonly ethnic food good safety records, our findings propose have potential therapeutic agents AD patients.

Language: Английский

Citations

0
An overview of the therapeutic potential of understudied lichen species for novel drug discovery DOI Creative Commons

Aswathy Venugopal,

Stephey Glaudline,

David Paul Raj

et al.

Journal of Applied and Natural Science, Journal Year: 2024, Volume and Issue: 16(4), P. 1516 - 1529

Published: Dec. 20, 2024

Due to the emergence of new diseases, drug discovery is an ever-exciting field science. Researchers have shifted their focus from chemical-based medicines drugs natural origin and structural synthetic analogues solve problem developing antibiotic resistance detrimental impacts existing chemical medications. Lichens are still one least explored sources for discovery. These slow-growing forms a rich source some exceptional secondary metabolites known collectively as lichenochemicals. The significant proportion these lichenochemicals bioactive compounds with multiple pharmacological properties, including antimicrobial, anticancer, free radical scavenging, anti-inflammatory, antidiabetic neuroprotective abilities also high in nutritional values, making this uncanny combination algae fungi, together metabolites, so well renowned traditional indigenous medicine. Although only oral knowledge was available about them earlier, studies over last few decades isolated identified unique medicinal lichen biology most interesting promising areas research. More than half species phytochemicals yet be explored. However, lichen-derived vitamin D3 vegan D3. Likewise, shown that can significantly reduce developed by microorganisms. Advanced techniques identification isolation, combined bioinformatics, predictive software, databases, greatly aided understanding chemistry. This review summarizes use lichens highlight on recent breakthroughs biology.

Language: Английский

Citations

0