Antidiabetic Effect of Borassus flabellifer L. Extracts on Streptozotocin-Induced Diabetic Rats DOI Creative Commons

Anitha Peter,

Nargis Begum Tajudheen,

Senthil Kumar Ramamoorthy

et al.

Biomedical and Biotechnology Research Journal (BBRJ), Journal Year: 2023, Volume and Issue: 7(1), P. 72 - 78

Published: Jan. 1, 2023

Background: Around the world, number of people with diabetes is rising at an alarming rate, and experts have been using ancient drugs that are mostly made from plants as treatments. This study aimed to see if Borassus flabellifer L. palm sprout ethanolic extracts could help treat in rats diabetic by streptozotocin (STZ). Methods: STZ (45 mg/kg bw) was injected once into peritoneum male albino Wistar rats. caused them get diabetes. For 60 days, intragastric intubation used give B. (400 glibenclamide (1 bw). Results: As a result, lost lot weight, their blood sugar glycosylated hemoglobin levels went up, total (Hb) down. Furthermore, glucose-6-phosphatase fructose-1,6-bis phosphatase were higher STZ, while hexokinase glycogen lower. When given sprouts glibenclamide, glucose Hb down very well, up. Changes how enzymes break carbohydrates liver work greatly improved. Conclusion: The results similar those standard drug glibenclamide. this back up traditional use plant

Language: Английский

HPLC-ESI-QTOF-MS Profiling of Antibacterial Bioactive Solvent Fractions of Senna alata (L.) Roxb (Fabaceae) Leaves, and in Silico Prediction of Pharmacokinetic, Drug-likeness, and Toxicity of Major Phyto-components DOI
Armel Jackson Seukep, Hélène Gueaba Mbuntcha,

Valaire Yemene Matieta

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119492 - 119492

Published: Feb. 1, 2025

Language: Английский

Citations

1
Phytotoxicity and Mode of Action of Phloretin on Maize Seedlings DOI
Renato Polimeni Constantin, Mariana C. Souza, Josielle Abrahão

et al.

Journal of Plant Growth Regulation, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Language: Английский

Citations

0
Phloretin supplementation ameliorates intestinal injury of broilers with necrotic enteritis by alleviating inflammation, enhancing antioxidant capacity, regulating intestinal microbiota, and producing plant secondary metabolites DOI Creative Commons
Mengjun Wu, Meng Peng,

J. Zang

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: unknown, P. 105187 - 105187

Published: April 1, 2025

The present study aimed to explore the effects of dietary phloretin (PT) on growth performance, immune response, and intestinal function in broilers with necrotic enteritis (NE). A total 288 1-day-old Arbor Acres chicks were assigned 3 groups, 8 replicates per group 12 replicate. Over 6 weeks, birds fed a basal diet or same supplemented 200 mg/kg phloretin. Birds challenged groups inoculated coccildia during d 7 9 Clostridium perfringens(CP) 14 18. Results showed that CP coccidia challenge reduced average daily gain feed intake, increased conversion ratio broilers, induced inflammation oxidative stress, inhibited mRNA expression levels for genes associated barrier nutrient transporters (P < 0.05). PT addition improved performance at early phase morphology, elevated antioxidant capacity via increasing activity superoxide dismutase ileum 0.01). Dietary regulated intesetinal as observed by increases content secretory IgA decreased cytokines (Interleukin-1β, Interleukin-10) Moreover, NE infection significantly disrupted balance flora, led lower level short-chain fatty acids such butyric acid concentration ileum, while microbiota structure, acetic 0.001). Furthermore, metabolomics analysis indicated treatment improve plant secondary metabolites contents like 2'-o-glucuronide. Additionally, we significant positive correlation among PT, Ligilactobacillus acid, between metabolites. Overall, supplementation could ameliorate injury enhancing function, regulating flora structure producing

Language: Английский

Citations

0
A dual approach to flavonoid toxicity assessment: Bridging computational and experimental paradigms DOI

Mriganka Das,

Sibashish Kityania,

P. D. Nath

et al.

Computational Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 100355 - 100355

Published: May 1, 2025

Language: Английский

Citations

0
High-Fat Diet Aggravates the Disorder of Glucose Metabolism Caused by Chlorpyrifos Exposure in Experimental Rats DOI Creative Commons
Jinwang Li, Xiude Li, Zhihui Zhang

et al.

Foods, Journal Year: 2023, Volume and Issue: 12(4), P. 816 - 816

Published: Feb. 14, 2023

Epidemiological research has demonstrated that the increase in high fat consumption promoted morbidity of diabetes. Exposure to organophosphorus pesticides (such as chlorpyrifos) may also risk Although chlorpyrifos is a frequently detected pesticide, interaction effect between exposure and high-fat diet on glucose metabolism still unclear. Thus, effects rats eating normal-fat or were investigated. The results glycogen content liver decreased increased chlorpyrifos-treated groups. Remarkably, ATP chlorpyrifos-treatment group was diet. However, treatment did not change serum levels insulin glucagon. Notably, contents ALT AST changed more significantly chlorpyrifos-exposed than group. Chlorpyrifos caused an MDA level decrease enzyme activities GSH-Px, CAT, SOD, changes significant indicated led disordered all dietary patterns result antioxidant damage liver, which have aggravated its toxicity.

Language: Английский

Citations

5
Phloretin prolongs lifespan of Caenorhabditis elegans via inhibition of NDUFS1 and NDUFS6 at mitochondrial complex Ⅰ DOI

Yu Zhang,

Yonglin Wu, Bin Li

et al.

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 221, P. 283 - 295

Published: May 3, 2024

Language: Английский

Citations

1
The harmful acute effects of clomipramine in the rat liver: Impairments in mitochondrial bioenergetics DOI Creative Commons
Paulo Francisco Veiga Bizerra, Fernanda Sayuri Itou da Silva, Eduardo Hideo Gilglioni

et al.

Toxicology Letters, Journal Year: 2023, Volume and Issue: 383, P. 1 - 16

Published: May 20, 2023

Language: Английский

Citations

1
Antidiabetic Effect of Borassus flabellifer L. Extracts on Streptozotocin-Induced Diabetic Rats DOI Creative Commons

Anitha Peter,

Nargis Begum Tajudheen,

Senthil Kumar Ramamoorthy

et al.

Biomedical and Biotechnology Research Journal (BBRJ), Journal Year: 2023, Volume and Issue: 7(1), P. 72 - 78

Published: Jan. 1, 2023

Background: Around the world, number of people with diabetes is rising at an alarming rate, and experts have been using ancient drugs that are mostly made from plants as treatments. This study aimed to see if Borassus flabellifer L. palm sprout ethanolic extracts could help treat in rats diabetic by streptozotocin (STZ). Methods: STZ (45 mg/kg bw) was injected once into peritoneum male albino Wistar rats. caused them get diabetes. For 60 days, intragastric intubation used give B. (400 glibenclamide (1 bw). Results: As a result, lost lot weight, their blood sugar glycosylated hemoglobin levels went up, total (Hb) down. Furthermore, glucose-6-phosphatase fructose-1,6-bis phosphatase were higher STZ, while hexokinase glycogen lower. When given sprouts glibenclamide, glucose Hb down very well, up. Changes how enzymes break carbohydrates liver work greatly improved. Conclusion: The results similar those standard drug glibenclamide. this back up traditional use plant

Language: Английский

Citations

0