Localization and Aggregation of Honokiol in the Lipid Membrane DOI Creative Commons
José Villalaı́n

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 1025 - 1025

Published: Aug. 22, 2024

Honokiol, a biphenyl lignan extracted from bark extracts belonging to Magnolia plant species, is pleiotropic compound which exhibits widespread range of antioxidant, antibacterial, antidiabetic, anti-inflammatory, antiaggregant, analgesic, antitumor, antiviral and neuroprotective activities. being highly hydrophobic, soluble in common organic solvents but insoluble water. Therefore, its biological effects could depend on bioactive mechanism. Although honokiol has many impressive properties, are unknown at the level membrane. Understanding honokiol’s mechanism unlock innovative perspectives for therapeutic development or molecules similar it. I have studied behaviour molecule presence plasma-like membrane established detailed relation with components using all-atom molecular dynamics. The results obtained this work sustain that tendency insert inside membrane; locates near below cholesterol oxygen atom, amid hydrocarbon palisade; increases slightly fluidity; does not interact specifically any lipid; and, significantly, forms aggregates. Significantly, aggregation impede going Some characteristics be accredited aptitude alter biophysical establishment aggregate solution might hamper clinical use.

Language: Английский

Unveiling the future of cancer stem cell therapy: a narrative exploration of emerging innovations DOI Creative Commons

Joseph Nhyira Obisi,

Abike Ndidiamaka Josephine Abimbola,

Oluwasegun Adesina Babaleye

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 22, 2025

Cancer stem cells (CSCs), are a critical subpopulation within tumours, and defined by their capacity for self-renewal, differentiation, tumour initiation. These unique traits contribute to progression, metastasis, resistance conventional treatments like chemotherapy radiotherapy, often resulting in cancer recurrence poor patient outcomes. As such, CSCs have become focal points developing advanced therapies. This review highlights progress CSC-targeted treatments, including chimeric antigen receptor T-cell (CAR-T) therapy, immunotherapy, molecular targeting, nanoparticle-based drug delivery systems. Plant-derived compounds gene-editing technologies, such as clustered regularly interspaced short palindromic repeats (CRISPR), explored potential enhance precision minimize side effects. Metabolic pathways integral CSC survival, mitochondrial dynamics, mitophagy (regulated dynamin-related protein 1 [DRP1] the PINK1/Parkin pathway), one-carbon metabolism, amino acid metabolism (involving enzymes glutaminase (GLS) glutamate dehydrogenase (GDH]), lipid hypoxia-induced metabolic reprogramming mediated hypoxia-inducible factors (HIF-1α HIF-2α), examined therapeutic targets. The adaptability of through autophagy, flexibility, epigenetic regulation metabolites α-ketoglutarate, succinate, fumarate is discussed. Additionally, extracellular vesicles nicotinamide adenine dinucleotide (NAD⁺) identified pivotal redox balance, DNA repair, modifications. Addressing challenges heterogeneity, immune evasion, treatment durability requires interdisciplinary collaboration. Advancing therapies essential overcoming preventing relapse, paving way transformative treatments. underscores importance leveraging innovative technologies fostering collaboration revolutionize treatment.

Language: Английский

Citations

1
Recent advances of honokiol：pharmacological activities, manmade derivatives and structure-activity relationship DOI
Xiuxia Li,

Zhuo Yuan,

Yu-Xia Wang

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 272, P. 116471 - 116471

Published: April 30, 2024

Language: Английский

Citations

7
Co-Delivery of Gemcitabine and Honokiol by Lipid Bilayer-Coated Mesoporous Silica Nanoparticles Enhances Pancreatic Cancer Therapy via Targeting Depletion of Tumor Stroma DOI Creative Commons
Dan Liu, Linjiang Wang, Henan Li

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(3), P. 675 - 675

Published: Jan. 31, 2024

Syndecan-1 (SDC1) modified lipid bilayer (LB)-coated mesoporous silica nanoparticles (MSN) to co-deliver gemcitabine (GEM) and honokiol (HNK) were prepared for the targeting treatment of pancreatic cancer. The encapsulation efficiencies GEM HNK in SDC1-LB-MSN-GEM/HNK determined be 60.3 ± 3.2% 73.0 1.1%. efficiency was investigated BxPC-3 cells vitro. fluorescence intensity treated with SDC1-LB-MSN-Cou6 2-fold LB-MSN-Cou6-treated cells, which caused by SDC1/IGF1R-mediated endocytosis. As anticipated, its cytotoxicity significantly increased. Furthermore, mechanism verified that SDC1-LB-MSN-HNK induced tumor cell apoptosis through mitochondrial pathway. Finally, biodistribution, growth inhibition, preliminary safety studies performed on BALB/c nude mice bearing models. inhibition index 56.19%, 1.45-fold 1.33-fold higher than free GEM/HNK LB-MSN-GEM/HNK groups, respectively. a result, combined advantages both simultaneously targeted eliminated cancerous cancer-associated stromal cells. In summary, present study demonstrated new strategy synergistic enhance therapeutic effect cancer via depletion stroma.

Language: Английский

Citations

4
Cell membrane sialome machinery and regulation of receptor tyrosine kinases in gliomas: The functional relevance and therapeutic perspectives DOI Open Access
Patrycja Jastrząb, Halina Car, Przemysław Wielgat

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 184, P. 117921 - 117921

Published: Feb. 21, 2025

Language: Английский

Citations

0
Inhibition of Ovarian Cancer Growth, Metastasis and Reverse the Tumor Microenvironment by Dual Drug-Loaded Polymer Micelle Targeting Tumor Microenvironment DOI Creative Commons
Lu Zhang,

Rui-bo Guo,

Muhan Chen

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2969 - 2990

Published: March 1, 2025

Introduction: Ovarian cancer is a malignant tumor that arises in the female reproductive system and associated with very high mortality rate. This primarily due to highly invasive nature of metastasis recurrence. Transforming immune environment from an immunosuppressive state anti-tumor through phenotypic transformation tumor-associated macrophages crucial for inhibiting growth, metastasis, recurrence ovarian cancer. Methods: A polymer micelle (RC-PH-Ms) containing paclitaxel (PTX) honokiol (HNK) was designed based on expression reactive oxygen species microenvironment. Once micelles are actively targeted microenvironment characterized by elevated levels species, responsive bond cleaved, thereby exposing secondary targeting ligand C7R. The released PTX HNK facilitate relevant M2 phenotype M1 phenotype, which turn inhibits invasion inhibit angiogenesis reduce Results: effects RC-PH-Ms modulating vascularization were investigated both vivo vitro. Conclusion: can significantly cancer, provides new perspective clinical treatment. Keywords: recrudescence, immunotherapy,

Language: Английский

Citations

0
Fisetin as a chemoprotective and chemotherapeutic agent: mechanistic insights and future directions in cancer therapy DOI
Rabab Fatima, Priyal Soni, Mousmee Sharma

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 12, 2025

Language: Английский

Citations

0
Honokiol induces paraptosis-like cell death through mitochondrial ROS-dependent endoplasmic reticulum stress in hepatocellular carcinoma Hep3B cells DOI
So Young Kim, Yung Hyun Choi

Toxicological Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 6, 2025

Language: Английский

Citations

0
Insights into Nimbolide molecular crosstalk and its anticancer properties DOI
Shabnum Shaheen, Sana Khalid,

Khadija Aaliya

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(6)

Published: May 18, 2024

Language: Английский

Citations

2
Dietary plants for oral cancer prevention and therapy: A review of preclinical and clinical studies DOI
Anupam Bishayee, A. Penn,

N. K. Bhandari

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(11), P. 5225 - 5263

Published: Aug. 28, 2024

Abstract Oral cancer is a disease with high mortality and rising incidence worldwide. Although fragmentary literature on the anti‐oral effects of plant products has been published, comprehensive analysis lacking. In this work, critical evaluation oral preventative or therapeutic dietary plants was conducted. An exhaustive available data supports that numerous exert anticancer effects, including suppression cell proliferation, viability, autophagy, angiogenesis, invasion, metastasis while promoting cycle arrest apoptosis. Plant extracts target several cellular mechanisms, such as reversal epithelial‐to‐mesenchymal transition promotion oxidative stress mitochondrial membrane dysfunction by modulation various signaling pathways. These agents were also found to regulate growth pathways action extracellular signal‐regulated kinase mitogen‐activated protein kinase, inflammation via cyclooxygenase (COX)‐1, COX‐2, nuclear factor‐κB p65, through influence cadherins matrix metalloproteinases. vivo studies support these findings demonstrate decrease in tumor burden, incidence, hyperplastic dysplastic changes. Clinical showed decreased risk. However, high‐quality should be conducted establish clinical efficacy plants. Overall, our study use plants, especially garlic, green tea, longan, peppermint, purple carrot, saffron, tomato, turmeric, for prevention intervention. further research required before application strategy.

Language: Английский

Citations

2
Honokiol Is More Potent than Magnolol in Reducing Head and Neck Cancer Cell Growth DOI Creative Commons
Robert Kleszcz, Dawid Dorna, Maciej Stawny

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(10), P. 10731 - 10744

Published: Sept. 25, 2024

The efficacy of treatment head and neck squamous cell carcinoma (HNSCC) patients is still unsatisfactory, there an ongoing search for novel therapies. Locoregionally advanced HNSCC cases, which frequently require combined surgery chemoradiotherapy, are especially difficult to treat. Natural compounds, like Magnolia-derived lignans—honokiol (HON) magnolol (MAG)—can reduce cancer growth but retain a good safety profile thus may show benefit as adjuvant therapeutics. aim this study was evaluate the anti-cancer effects HON MAG in lines compare their between cisplatin-sensitive cisplatin-tolerant cells. Cell viability evaluated FaDu SCC-040 cells growing monolayers spheroids. effect on cycle, apoptosis, gene expression compared wild-type cisplatin persister We observed that were more potent reducing cells, although not directly followed by increased rates apoptosis. Thus, HON’s MAG’s capacity affect needs further studies. In general, we exerted stronger cytotoxic than difference activity pronounced cultured 3D.

Language: Английский

Citations

1