Exosomal ncRNAs in liquid biopsies for lung cancer

Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: 565, P. 119983 - 119983

Published: Oct. 3, 2024

Language: Английский

---

GAS5 lncRNA: A biomarker and therapeutic target in breast cancer

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155424 - 155424

Published: June 20, 2024

Language: Английский

---

Ambient formaldehyde combined with high temperature exposure and respiratory disease admissions among children: a time-series study across multiple cities

Thorax, Journal Year: 2025, Volume and Issue: unknown, P. thorax - 222709

Published: March 31, 2025

Introduction Ambient formaldehyde (HCHO) is globally distributed, posing significant exposure to vast populations, particularly vulnerable demographics such as children. Investigations into the correlation between ambient HCHO and children’s respiratory ailments are deficient. Methods was retrieved from TROPOspheric Monitoring Instrument. A two-stage time-series analysis conducted examine relationship hospital admission of diseases among 198 704 children in Jiangsu Province, China, 2019 2021. Additionally, 12 patterns were defined further discern potential synergistic effects high temperature combined exposure. Results After controlling for relevant covariates, our findings revealed associated with respiratory-related admissions. Specifically, we identified a pronounced effect at lag 3 day, demonstrating 1.14% increase (95% CI: 0.60%, 1.69%). Subgroup analyses that warm season, 3–7 years old group disadvantaged economic areas showed higher risk. Moreover, found would trigger elevated risk admission. Notably, specific scenarios, cumulative relative reached up 1.051 1.025, 1.078), highlighting on health Conclusions increased risks children, could To have an in-depth understanding impact critical intervention strategies aimed mitigating pollution regarding adverse impacts under changing climate.

Language: Английский

---

Indoor Air Pollution and Airway Health

Journal of Allergy and Clinical Immunology, Journal Year: 2024, Volume and Issue: 154(4), P. 835 - 846

Published: Aug. 24, 2024

Because of the disproportionate amount time that people spend indoors and complexities air pollutant exposures found there, indoor pollution is a growing concern for airway health. Both infiltration outdoor into space sources (such as smoke from tobacco products, cooking or heating practices combustion associated fuels, household materials) contribute to unique exposure mixtures. Although there substantial literature on chemistry pollution, research focused health effects only beginning emerge remains an important area need protect public We provide review emerging spanning past 3 years relating health, with specific focus impact either individual common lower airways. Factors defining susceptibility and/or vulnerability are reviewed consideration priority populations modifiable risk factors may be targeted advance equity.

Language: Английский

---

Therapeutic approaches targeting aging and cellular senescence in Huntington's disease

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(10)

Published: Oct. 1, 2024

Huntington's disease (HD) is a devastating neurodegenerative that manifested by gradual loss of physical, cognitive, and mental abilities. As the advances, age has major impact on pathogenic signature mutant huntingtin (mHTT) protein aggregation. This review aims to explore intricate relationship between aging, mHTT toxicity, cellular senescence in HD. Scientific data interplay mHTT, HD were collected from several academic databases, including PubMed, Google Scholar, Google, ScienceDirect. The search terms employed "AGING," "HUNTINGTON'S DISEASE," "MUTANT HUNTINGTIN," "CELLULAR SENESCENCE." Additionally, gather information molecular mechanisms potential therapeutic targets, was extended include relevant such as "DNA DAMAGE," "OXIDATIVE STRESS," "AUTOPHAGY." According research, aging leads worsening pathophysiology through some processes. result accumulation, promoted, which causes DNA damage, oxidative stress, decreased autophagy, increased inflammatory responses. Pro-inflammatory cytokines other substances are released senescent cells, may worsen neuronal damage course disease. It been shown treatments directed at these pathways reduce symptoms enhance longevity experimental animals, pointing new possibility treating condition. Through their amplification harmful effects play crucial roles development Comprehending interplays creates novel opportunities for measures targeted alleviating enhancing patients' quality life.

Language: Английский

---

Harnessing Pyroptosis for Lung Cancer Therapy: The Impact of NLRP3 Inflammasome Activation

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155444 - 155444

Published: Aug. 1, 2024

Language: Английский

---

Formaldehyde and asthma: a plausibility?

Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Language: Английский

---

Toxicity of formaldehyde, and its role in the formation of harmful and aromatic compounds during food processing

Food Chemistry X, Journal Year: 2025, Volume and Issue: 25, P. 102225 - 102225

Published: Jan. 1, 2025

Language: Английский

---

Pathological Interplay of NF-κB and M1 Macrophages in Chronic Inflammatory Lung Diseases

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 269, P. 155903 - 155903

Published: March 7, 2025

Language: Английский

---

Biodegradable Porous Adsorbent for Efficient Formaldehyde Removal from Indoor Air

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121453 - 121453

Published: March 1, 2025

Language: Английский

---