Bioactive Peptide-MOF based nanogel for peripheral nerve repair through remodeling the regenerative microenvironment

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161831 - 161831

Published: March 1, 2025

Language: Английский

---

Alzheimer’s, Parkinson’s, Frontotemporal Lobar Degeneration, and Amyotrophic Lateral Sclerosis Start in Pediatric Ages: Ultrafine Particulate Matter and Industrial Nanoparticles Are Key in the Early-Onset Neurodegeneration: Time to Invest in Preventive Medicine

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 178 - 178

Published: Feb. 28, 2025

Billions of people are exposed to fine particulate matter (PM2.5) levels above the USEPA’s annual standard 9 μg/m3. Common emission sources anthropogenic, producing complex aerosolized toxins. Ultrafine (UFPM) and industrial nanoparticles (NPs) have major detrimental effects on brain, but USA does not measure UFPM a routine basis. This review focuses development progression common neurodegenerative diseases, as diagnosed through neuropathology, among young residents in Metropolitan Mexico City (MMC). MMC is one most polluted megacities world, with population 22 million residents, many whom unaware brain caused by their atmosphere. Fatal diseases (such Alzheimer’s Parkinson’s) that begin childhood populations living air environments preventable. We conclude UFPM/NPs capable disrupting neural homeostasis give rise relentless processes throughout entire life highly MMC. The paradigm reaching old age neurodegeneration no longer supported. Neurodegenerative changes start early pediatric ages irreversible. It time invest preventive medicine.

Language: Английский

---

Nanoparticles induced neurotoxicity

Nanotoxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 28

Published: April 16, 2025

The early development of nanotechnology has spurred major interest on the toxicity nanoparticles (NPs) due to their ability penetrate biological barriers such as BBB. This review aims at addressing how silver (AgNPs), titanium dioxide (TiO2NPs), zinc oxide (ZnONPs), iron (Fe3O4NPs), carbon NPs, Copper (Cu-NPs), silicon (SiO2 NPs) and quantum dots cause neurotoxicity. Some signaling that occur are related oxidative stress, neuroinflammation, mitochondrial dysfunction cell equilibrium, hence results in neuronal damage neurodegeneration. It is critical describe there multiple ways by NPs may be toxic based size surface, dosage, recipient's age health condition. A vitro vivo analysis provides information about potentials preventive measures including modification NP surface antioxidant treatment. underline necessity comprehensive safety assessments allow further utilization across economy.

Language: Английский

---

Nanomaterials in Regenerative Medicine: Advancing the Future of Tissue Engineering

Regenerative Engineering and Translational Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Language: Английский

---