Nanomaterials for Endogenous and Exogenous Hydrogen Sulfide-Based NIR Photothermal Cancer Therapy: A Review DOI

Yucheng Zeng,

Tianyu Wu, Qingshan Pan

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(20), P. 23397 - 23415

Published: Oct. 12, 2024

Hydrogen sulfide (H2S) is recognized as the third gaseous signaling molecule present, playing a crucial role in cellular processes. When designing nanomaterials, H2S not only serves cancer biomarker but also directly influences tumor cell proliferation and metastasis by modulating its concentration. However, gas donor inability to actively accumulate within tumors release controlled manner results restricted treatment efficacy potential toxic side effects. Near-infrared (NIR) responsive photothermal probes are characterized their rapid response time, high selectivity, sensitivity, noninvasive attributes. They offer opportunity for precise, real-time, modulation of concentrations at both murine levels. The integration therapy with other modalities through multifunctional nanocarrier platforms shows promise enhancing outcomes while minimizing adverse development capable controllably properties considered essential yet challenging academic research. This Review critically assesses two primary approaches NIR strategies involving H2S: targeted utilizing combining alternative modalities. Additionally, this addresses current limitations these technologies outlines future directions advancement. Overall, aims provide insights guidance seamless therapy, aligning rigorous standards journals.

Language: Английский

O-GlcNAcylation of DJ-1 suppresses ferroptosis in renal cell carcinoma by affecting the transsulfuration pathway DOI

Zhiwei Yan,

Yanze Li,

Minghui Wang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114098 - 114098

Published: Jan. 21, 2025

Language: Английский

Citations

0
Synthetic Organic Polysulfanes as H2S Donors and Anticancer Agents DOI

Abu Sufian,

Debojit Bhattacherjee, Pallavi Barman

et al.

Chemical Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The present review primarily focuses on highlighting recent developments in the synthesis of H 2 S-donating organic polysulfanes and their potential pharmacological implications for cancer.

Language: Английский

Citations

0
Realigned transsulfuration drives BRAF-V600E-targeted therapy resistance in melanoma DOI

Klaudia Borbényi-Galambos,

Katalin Erdélyi,

Tamás Ditrói

et al.

Cell Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Nanomaterials for Endogenous and Exogenous Hydrogen Sulfide-Based NIR Photothermal Cancer Therapy: A Review DOI

Yucheng Zeng,

Tianyu Wu, Qingshan Pan

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(20), P. 23397 - 23415

Published: Oct. 12, 2024

Hydrogen sulfide (H2S) is recognized as the third gaseous signaling molecule present, playing a crucial role in cellular processes. When designing nanomaterials, H2S not only serves cancer biomarker but also directly influences tumor cell proliferation and metastasis by modulating its concentration. However, gas donor inability to actively accumulate within tumors release controlled manner results restricted treatment efficacy potential toxic side effects. Near-infrared (NIR) responsive photothermal probes are characterized their rapid response time, high selectivity, sensitivity, noninvasive attributes. They offer opportunity for precise, real-time, modulation of concentrations at both murine levels. The integration therapy with other modalities through multifunctional nanocarrier platforms shows promise enhancing outcomes while minimizing adverse development capable controllably properties considered essential yet challenging academic research. This Review critically assesses two primary approaches NIR strategies involving H2S: targeted utilizing combining alternative modalities. Additionally, this addresses current limitations these technologies outlines future directions advancement. Overall, aims provide insights guidance seamless therapy, aligning rigorous standards journals.

Language: Английский

Citations

0