The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(9)
Published: May 2, 2025
ABSTRACT The alpha‐Gal syndrome (AGS) is an underdiagnosed tick‐borne allergy characterized by both immediate and delayed IgE‐mediated anaphylactic reactions to the galactose‐alpha‐1,3‐galactose (alpha‐Gal) epitope. Common manifestations include gastrointestinal, cutaneous, respiratory symptoms appearing 2–6 h after consumption of mammalian meat or derived products. Zebrafish ( Danio rerio ) are emerging as essential animal models in biomedical studies, due their anatomical, genetic, physiological similarities humans, with significant applications toxicology, behavioral research, oncology, inflammation studies. mechanisms associated AGS sustained studies humanized α1,3GalT‐KO C57BL/6 mouse Mus musculus zebrafish for production anti‐alpha‐Gal antibodies response tick saliva, development allergic animals sensitized protein extracts following consumption, identification immune mechanisms. a skewed type 2 response, triggering Toll‐Like receptor (TLR) signaling pathways, IL‐4 production, humoral activity. These results support use rather than single one more comprehensive characterization AGS‐associated In this study, we focused on model biomedicine research immunity, infectious, diseases, particular emphasis candidate therapeutic interventions. Based insights from multiple concluded that suitable studying AGS, considering addressed limitations combination model.
Language: Английский