The Role of Estrogen and Thyroid Hormones in Zebrafish Visual System Function

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Feb. 28, 2022

Visual system development is a highly complex process involving coordination of environmental cues, cell pathways, and integration functional circuits. Consequently, change to any step, due mutation or chemical exposure, can lead deleterious consequences. One class chemicals known have both overt subtle effects on the visual endocrine disrupting compounds (EDCs). EDCs are contaminants which alter hormonal signaling by either preventing compound synthesis binding postsynaptic receptors. Interestingly, recent work has identified neuronal sensory systems, particularly vision, as targets for EDCs. In particular, estrogenic thyroidogenic been critical modulators proper function. Here, we summarize review this work, from our lab others, focusing behavioral, physiological, molecular data collected in zebrafish. We also discuss different exposure regimes used, including long-lasting developmental exposure. Overall, zebrafish model choice examine impact other targeting estrogen thyroid consequences

Language: Английский

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Does dietary exposure to 17α-ethinylestradiol alter biomarkers related with endocrine disruption and oxidative stress in the adult triploid of Danio rerio?

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 870, P. 161911 - 161911

Published: Jan. 31, 2023

Language: Английский

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DNA damage, alterations in the expression of antioxidant enzyme genes and in the histoarchitecture of gill cells of zebrafish exposed to 17-α-ethinylestradiol

Drug and Chemical Toxicology, Journal Year: 2023, Volume and Issue: unknown, P. 1 - 7

Published: March 13, 2023

Endocrine disruptors, such as estrogen, are chemical substances with the potential to alter hormonal balance of organisms. Their origin can be natural or artificial, and they act at very low doses. The estrogen 17α-ethinylestradiol (EE2) is used worldwide an oral contraceptive a contaminant in aquatic ecosystems. It well documented that these environmental pollutants directly indirectly on reproductive system, impairing development fertility. However, little known about alteration cell oxidative status induced by EE2. main objective this study was evaluate effect gill cells adult zebrafish exposed vivo EE2, analyzing histology, DNA damage expression levels genes encoding enzymes involved stress pathways. histological showed EE2 produces moderate high tissue, increase mRNA corresponding manganese superoxide dismutase (Mn-sod) catalase (cat) after exposure 5 ng/L results indicate causes tissue alterations, stress. produced important alterations gills, fundamental organ for survival fish. There clear need further research ecological consequences EDCs non-target

Language: Английский

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Cubic cobalt ferrite anchored on graphene sheets for non-enzymatic electrochemical detection of 17α-ethinyl estradiol in environmental and biological samples

Journal of environmental chemical engineering, Journal Year: 2023, Volume and Issue: 12(1), P. 111612 - 111612

Published: Dec. 6, 2023

Language: Английский

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Zebrafish as Model Organism in Aquatic Ecotoxicology: Current Trends and Future Perspectives

IntechOpen eBooks, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 11, 2023

Assessing the welfare of aquatic ecosystems has gained immense importance within scientific community, elevating ecotoxicology to a fundamental discipline. This field utilizes bioindicators, often referred as model organisms, investigate harmful effects environmental pollution. Amid this array biological markers, zebrafish stands out an exceptional contender. The primary objective present investigation is highlight complete information available in literature about utilization ecotoxicology. Zebrafish are commonly utilized research study reproductive and embryonic toxicity due their intricate sex-determination mechanism, which significantly impacted by factors. Similarly, particular fish species also employed studying neuronal signaling, behavior, DNA damage from pollutants susceptibility swimming abilities around day five post-fertilization. In addition established methodologies, recent advancements toxicology have incorporated into emerging genome editing techniques. These innovative approaches provide fresh compelling avenues for exploring detoxification mechanisms organisms’ adaptive responses stressors. conclusion, important providing profound insights diverse facets ecotoxicological investigations. Furthermore, relevance further underscored adaptability evolving technologies.

Language: Английский

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Acute toxicity induced by treated sewage to zebrafish (Danio rerio)

Agro Productividad, Journal Year: 2024, Volume and Issue: unknown

Published: April 15, 2024

Objetivo: Se evaluaron marcadores de toxicidad aguda en pez cebra causados por la exposición a aguas residuales tratadas dos plantas tratamiento para obtener información precisa y relevante sobre los riesgos potenciales salud ambiental asociados con estas aguas. Diseño/metodología/aproximación: La evaluación se realizó acuerdo lineamientos propuestos Organización Cooperación el Desarrollo Económicos (OECD). Para determinar Dilución Letal Media (LDil50) analizaron cinco proporciones cada tipo agua tratada del grifo declorada (20, 40, 60, 80 100%). descripción efectos teratogénicos mediante biomarcador columna vertebral. Resultados: Los resultados revelaron que mezcla residual (mCl) desinfectada hipoclorito sodio (NaClO) causaron tóxicos embriones cebra, como letalidad, malformaciones alteraciones cardiacas. Por otra parte, Macroplanta Bahía Banderas (BBdClO) no fue tóxica 96 horas exposición. Limitaciones estudio/implicaciones: Sería recomendable caracterizar las tratamiento. Hallazgos/conclusiones: Estos hallazgos subrayan importancia evaluar sus corto largo plazo organismos acuáticos, proporcionando valiosa gestión recursos hídricos protección medio ambiente.

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