Microbiome interactions with different risk factors in development of myocardial infarction

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 189, P. 112409 - 112409

Published: March 27, 2024

Among all non-communicable diseases, Cardiovascular Diseases (CVDs) stand as the leading global cause of mortality. Within this spectrum, Myocardial Infarction (MI) strikingly accounts for over 15 % deaths. The intricate web risk factors MI, comprising family history, tobacco use, oral health, hypertension, nutritional pattern, and microbial infections, is firmly influenced by human gut microbiota, their diversity, richness, dysbiosis, along with respective metabolites. Host genetic factors, especially allelic variations in signaling inflammatory markers, greatly affect progression or severity disease. Despite established significance microbiome-nutrient-metabolite interplay associations CVDs, unexplored terrain gut-heart-oral axis has risen a critical knowledge gap. Moreover, pivotal role microbiome complex host genetics, compounded age-related changes, emerges an area vital importance development MI. In addition, distinctive disease susceptibility gender-based ancestral differences, adds crucial insights to association increased Here, we aimed provide overview on interactions (oral gut) major (tobacco alcohol consumption, diet, hypertension gender, aging) MI therapeutic regulation.

Language: Английский

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Blood microbiome and cardiometabolic disease: insights, therapeutic strategies, and future directions

Frontiers in Bacteriology, Journal Year: 2025, Volume and Issue: 4

Published: March 3, 2025

Cardiometabolic diseases (CMDs), particularly cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), and chronic kidney (CKD), emerged as primary contributors to global morbidity mortality. In addition traditional factors, recent studies demonstrated that blood microbiomes may also promote the development or progression of these CMDs. Traditionally, was considered sterile; however, notion a sterile environment has been challenged by findings demonstrating presence microbiome in both healthy states. Although there tremendous expansion human research, with hundreds projects underway globally not received same level attention its gut oral counterparts. The circulating is an emerging trend drawn high interest biomedical field, given potential generate predictive biomarkers means screen for pathogens. This comprehensive review explores latest advancements emphasizing biomarker identification, diagnostic tools, treatment modalities, prevention We delve into existing challenges present future-oriented strategy using advanced methods. Deciphering microbiome’s role could lead classification patient subgroups, enabling precision microbiota-based therapies.

Language: Английский

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Distinct blood and oral microbiome profiles reveal altered microbial composition and functional pathways in myocardial infarction patients

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 14, 2025

Introduction The blood microbiome, increasingly recognized as a distinct microbial niche, may originate partly from oral translocation. We systematically compared circulating and microbiome profiles between healthy individuals myocardial infarction (MI) patients to identify disease-associated signatures. Methods current study recruited 20 participants, including 10 controls with MI. Blood Saliva samples were collected each participant analyze the association in MI using 16S rRNA gene sequencing. Results showed significantly greater alpha diversity than (p<0.05), but beta did not differ significantly. had higher levels of Firmicutes, Bacteroidota, Actinobacteriota, genus Bacteroides, lower Proteobacteria, whereas was dominated by Veillonella, Prevotella_7. LEfSe analysis revealed taxa-Actinobacteria Enterobacterales controls. In contrast, microbiota subjects enriched Rothia, Micrococcaceae, Micrococcales, while no taxa associated Both microbiomes significant functional pathway differences (KEGG) groups. Additionally, signatures correlated clinical demographic markers. Discussion Our demonstrates that harbors characterized specific pathways rather merely reflecting bacterial These findings suggest play an active role pathology Furthermore, we identified associations these disease This highlights potential importance understanding mechanisms underlying its diagnostic or therapeutic implications.

Language: Английский

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Insights into the blood, gut, and oral microbiomes in Chinese patients with myocardial infarction: a case-control study

BMC Microbiology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 19, 2025

Emerging evidence suggests that changes in the blood microbes might be associated with cardiovascular disease, especially myocardial infarction (MI). However, some researchers are questioning whether a true "blood microbiome" actually exists. They hypothesized these may translocate into bloodstream from gut or oral cavities. To test this hypothesis, we analyzed microbial composition, diversity, and potential role disease progression by comparing blood, gut, microbiota profiles cohort of MI patients healthy controls. In study, 144 samples, including fecal, saliva, were collected twenty-four These samples using 16 S rRNA sequencing to characterize across three distinct compartments. Differential analyses conducted find key differential for MI. Spearman's rank correlation analysis was used study association between clinical indicators. Our findings revealed striking shifts compartments compared observed significant enrichment phyla Armatimonadota Caldatribacteriota, alongside genera Bacillus, Pedobacter, Odoribacter. The showed notable increase Proteobacteria, Verrucomicrobiota, Cyanobacteria, Synergistota, Crenarchaeota, as well Eubacterium_coprostanoligenes_group, Rothia, Akkermansia, Lachnospiraceae_ NK4A136_ group, Eubacterium_ruminantium_group. Meanwhile, uniquely enriched phylum Elusimicrobiota Streptococcus, Granulicatella. signatures highlight compartment-specific alterations play pathophysiology Additionally, LEfSe identified 64 taxa differed Of these, eight unique eighteen thirty-eight microbiota, all which demonstrated associations markers Functional pathways predicted via KEGG annotation, but no statistically differences found controls any microbiome This demonstrates patients, identifying specific bacterial strongly infarction. patterns detected provide compelling existence stable core microbiome, highlighting its importance contributor health progression.

Language: Английский

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Insights into the blood, gut, and oral microbiomes of myocardial infarction patients

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Background A growing body of evidence links shifts in blood microbial composition with cardiovascular diseases, particularly myocardial infarction (MI). Recent studies have raised questions regarding a core microbiome's existence, positing that microbes may translocate from the gut or oral cavities into bloodstream. To test this hypothesis, here we examined blood, gut, and microbiome cohort MI patients healthy people (HP). Methods total 144 samples were collected 48 participants, including stool, saliva 24 HP patients. The then analyzed using 16S rRNA gene sequencing to achieve comprehensive profiling. Results Our findings revealed significant between both groups. Notably, exhibited distinct increase abundance Selenomonadaceae, Enterobacterales, Dialister within their microbiota. Similarly, microbiomes showed elevated levels Actinobacteriota, Streptococcaceae, Micrococcaceae, Coriobacteriaceae, genera Streptococcus, Rothia, Granulicatella. also potential associations specific bacteria markers. Gut such as Lachnospirales, Clostridia, Bifidobacteriales, Bifidobacterium, Lachnospiraceae, Blautia, along like Fusobacteriaceae, Fusobacterium, Fusobacteriales, Fusobacteria, show markers triglycerides, LDL, neutrophils, hemoglobin, uric acid, fasting glucose, platelets, cholesterol. Conversely, analyses no notable distinctions alpha diversity, beta predicted functional pathways Conclusion This study identifies patients, linked key markers, underscoring gut-oral-cardiovascular axis disease progression. lack unique signatures supports translocation rather than stable microbiome, highlighting microbiota players health.

Language: Английский

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