Serum neuritin as a predictive biomarker of early neurological deterioration and poor prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

Intracerebral hemorrhage (ICH) is a common cerebrovascular disease characterized by high mortality and disability rates. Neuritin, significantly expressed in injured brain tissues, implicated the molecular mechanisms underlying acute injury. We aimed to explore prognostic predictive value of serum neuritin ICH. In this prospective cohort study, levels were measured at admission 202 patients, on post-ICH days 1, 3, 5, 7, 10 54 these time enrollment 100 healthy controls. The Glasgow Coma Scale (GCS) hematoma volume used as severity indicators. A poor prognosis was defined modified Rankin (mRS) score 3-6 90 after END decrease ≥2 points GCS within 24 h admission. multivariate logistic regression model assess independent relationships between levels, END, prognosis. Serum increased patient admission, continued rise day peaked then gradually diminished from 5 until 10. remained substantially higher patients compared controls throughout 10-day period. independently related scores volume. subgroup analyses, showed linear relationship with likelihood experiencing 90-day mark Additionally, associated ordinal mRS scores, Under receiver operating characteristic (ROC) curve analysis, effectively predicted both Two models incorporating GCS, volume, developed represented using two nomograms separately estimate risks These demonstrated clinical efficiency, stability, validity ROC, calibration, decision analyses. Internal validation conducted randomly extracted subset 101 patients. Furthermore, specific weighted scoring systems optimize prediction Elevated are strongly severity, neurological outcomes following ICH, establishing potential biomarker for

Language: Английский

Receptor-Interacting Protein Kinase 3 as a Serological Biomarker in Relation to Disease Severity and Delirium After Acute Pancreatitis: A Prospective Cohort Study

International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 5309 - 5323

Published: Nov. 1, 2024

Delirium is a common complication of acute pancreatitis. Receptor-interacting protein kinase 3 (RIP3) an activator programmed cell necrosis. This study aimed to determine its ability predict delirium after

Language: Английский