The association of serum total bile acids and deep venous thrombosis

Thrombosis Journal, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 7, 2025

Bile acid metabolism plays a crucial role in maintaining the delicate balance between coagulation and anticoagulation processes. However, there is paucity of research exploring relationship serum total bile acids (TBA) levels risk deep venous thrombosis (DVT) Chinese individuals. The primary objective this study to investigate association TBA DVT occurrence population. A cross-sectional was conducted involving 4522 patients with suspected DVT, recruited from June 2018 October 2023, at First Affiliated Hospital Xi'an Jiaotong University. After rigorous screening, 3165 were included final analysis. Participants categorized into three level groups: low-level (TBA < 2.3 umol/L), moderate-level (2.3 ≤ 4.3 high-level ≥ umol/L). Logistic regression analysis utilized assess risk, adjusting for potential confounders. median age population 63 years, 3.2 (1.9–5.3) umol/L. findings revealed that, compared group, moderate groups had significantly higher odds ratios (ORs) ORs 1.47 (95% CI: 1.21 1.78, P 0.001) 1.91 1.58 2.32, 0.001), respectively. Interestingly, also associated reduced bleeding 0.81 0.63 1.03, 0.64 0.5 0.81, Our provides evidence that may serve as factor individuals, conferring an increased risk. Additionally, unexpectedly, found be complications. These have significant implications understanding complex interplay thrombosis, warrant further investigation.

Language: Английский

Bile acid resource compounds: reactions and applications in natural products synthesis

Scientia Sinica Chimica, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Clinical application of bile acid profile combined with lipid indices in metabolic dysfunction-associated steatotic liver disease

Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 120217 - 120217

Published: Feb. 1, 2025

Language: Английский