Extracellular Vesicles as Epigenetic Regulators of Redox Homeostasis: A Systematic Review and Meta-Analysis DOI Creative Commons
Cristina Mas‐Bargues,

Javier Huete-Acevedo,

Marta Arnal-Forné

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 532 - 532

Published: April 29, 2025

Extracellular vesicles (EVs) are emerging as key regulators of cellular communication, with increasing evidence supporting their role in oxidative stress (OS) modulation. In particular, the miRNA cargo EVs plays a crucial mitigating OS and promoting redox balance through both direct antioxidant effects epigenetic regulation. This study aimed to evaluate impact on markers, influenced by miRNA-mediated potential modifications target cells. A systematic literature search was conducted following Preferred Reporting Items for Systematic Reviews Meta-Analysis (PRISMA) guidelines identify studies reporting parameters. meta-analysis performed biomarkers, including reactive oxygen species (ROS), superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA). The heterogeneity EV isolation characterization techniques also analyzed. included demonstrated that exert significant reducing ROS levels, SOD activity GSH lowering MDA levels. These were largely attributed EV-miRNAs, which induce modulate redox-related signaling pathways. However, variability methods approaches highlights need standardization improve data comparability. Despite therapeutic potential, this research remains barrier translation. Moreover, further exploration mechanisms is essential fully harness benefits OS-related diseases.

Language: Английский

Extracellular Vesicles as Epigenetic Regulators of Redox Homeostasis: A Systematic Review and Meta-Analysis DOI Creative Commons
Cristina Mas‐Bargues,

Javier Huete-Acevedo,

Marta Arnal-Forné

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 532 - 532

Published: April 29, 2025

Extracellular vesicles (EVs) are emerging as key regulators of cellular communication, with increasing evidence supporting their role in oxidative stress (OS) modulation. In particular, the miRNA cargo EVs plays a crucial mitigating OS and promoting redox balance through both direct antioxidant effects epigenetic regulation. This study aimed to evaluate impact on markers, influenced by miRNA-mediated potential modifications target cells. A systematic literature search was conducted following Preferred Reporting Items for Systematic Reviews Meta-Analysis (PRISMA) guidelines identify studies reporting parameters. meta-analysis performed biomarkers, including reactive oxygen species (ROS), superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA). The heterogeneity EV isolation characterization techniques also analyzed. included demonstrated that exert significant reducing ROS levels, SOD activity GSH lowering MDA levels. These were largely attributed EV-miRNAs, which induce modulate redox-related signaling pathways. However, variability methods approaches highlights need standardization improve data comparability. Despite therapeutic potential, this research remains barrier translation. Moreover, further exploration mechanisms is essential fully harness benefits OS-related diseases.

Language: Английский

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