piR-38,736 promotes gastric cancer cell proliferation by downregulating SMAD4 expression DOI Creative Commons
Dongmei Liu, Chenghai Wang, Hongshan Ge

et al.

Journal of Molecular Histology, Journal Year: 2025, Volume and Issue: 56(2)

Published: April 1, 2025

PIWI-interacting RNAs (piRNAs) play an important role in cancer development and progression. Although recent studies had advanced our understanding of the functions various piRNAs cancer, specific piR-38736 gastric remained poorly understood. This study aimed to investigate clinical significance underlying mechanisms cancer. found that was significantly upregulated cells tissues. Positive expression closely correlated with larger tumor size medium poor differentiation. Survival analysis revealed patients positive shorter survival times compared those negative expression. Knockdown markedly inhibited cell proliferation growth Furthermore, directly bind 3' untranslated region (UTR) SMAD4 mRNA, resulting significant downregulation at both mRNA protein levels upon overexpression piR-38,736. In conclusion, these findings indicate piR-38,736 promotes by downregulating may serve as a prognostic biomarker potential therapeutic target for Further are required fully elucidate explore its implications management.

Language: Английский

piR-38,736 promotes gastric cancer cell proliferation by downregulating SMAD4 expression DOI Creative Commons
Dongmei Liu, Chenghai Wang, Hongshan Ge

et al.

Journal of Molecular Histology, Journal Year: 2025, Volume and Issue: 56(2)

Published: April 1, 2025

PIWI-interacting RNAs (piRNAs) play an important role in cancer development and progression. Although recent studies had advanced our understanding of the functions various piRNAs cancer, specific piR-38736 gastric remained poorly understood. This study aimed to investigate clinical significance underlying mechanisms cancer. found that was significantly upregulated cells tissues. Positive expression closely correlated with larger tumor size medium poor differentiation. Survival analysis revealed patients positive shorter survival times compared those negative expression. Knockdown markedly inhibited cell proliferation growth Furthermore, directly bind 3' untranslated region (UTR) SMAD4 mRNA, resulting significant downregulation at both mRNA protein levels upon overexpression piR-38,736. In conclusion, these findings indicate piR-38,736 promotes by downregulating may serve as a prognostic biomarker potential therapeutic target for Further are required fully elucidate explore its implications management.

Language: Английский

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