Immunotherapies for hepatocellular carcinoma

Nature Reviews Clinical Oncology, Journal Year: 2021, Volume and Issue: 19(3), P. 151 - 172

Published: Nov. 11, 2021

Language: Английский

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The updated landscape of tumor microenvironment and drug repurposing

Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)

Published: Aug. 25, 2020

Abstract Accumulating evidence shows that cellular and acellular components in tumor microenvironment (TME) can reprogram initiation, growth, invasion, metastasis, response to therapies. Cancer research treatment have switched from a cancer-centric model TME-centric one, considering the increasing significance of TME cancer biology. Nonetheless, clinical efficacy therapeutic strategies targeting TME, especially specific cells or pathways remains unsatisfactory. Classifying chemopathological characteristics crosstalk among one another greatly benefit further studies exploring effective treating methods. Herein, we present an updated image with emphasis on hypoxic niche, immune microenvironment, metabolism acidic innervated mechanical microenvironment. We then summarize conventional drugs including aspirin, celecoxib, β-adrenergic antagonist, metformin, statin new antitumor application. These are considered as viable candidates for combination therapy due their activity extensive use practice. also provide our outlook directions potential applications theory. This review depicts comprehensive vivid landscape biology treatment.

Language: Английский

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Diversity and Biology of Cancer-Associated Fibroblasts

Physiological Reviews, Journal Year: 2020, Volume and Issue: 101(1), P. 147 - 176

Published: May 29, 2020

Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial compartment, despite presence of non-neoplastic stromal components that substantially contribute progression tumor. Indeed, cancer cell survival, growth, migration, and even dormancy are influenced by surrounding tumor microenvironment (TME). Within TME, cancer-associated fibroblasts (CAFs) been shown play several roles in development a They secrete growth factors, inflammatory ligands, extracellular matrix proteins promote proliferation, therapy resistance, immune exclusion. However, recent work indicates CAFs may also restrain some circumstances. In this review, we summarize body CAFs, with particular focus most discoveries about fibroblast heterogeneity, plasticity, functions. We highlight commonalities present across different types, normal states. Finally, latest advances regarding therapeutic strategies undergoing preclinical clinical evaluation.

Language: Английский

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Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma

Cell, Journal Year: 2020, Volume and Issue: 184(2), P. 404 - 421.e16

Published: Dec. 23, 2020

Language: Английский

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Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: May 5, 2021

Abstract Lung cancer is a highly heterogeneous disease. Cancer cells and within the tumor microenvironment together determine disease progression, as well response to or escape from treatment. To map cell type-specific transcriptome landscape of their in advanced non-small lung (NSCLC), we analyze 42 tissue biopsy samples stage III/IV NSCLC patients by single RNA sequencing present large scale, resolution profiles NSCLCs. In addition types described previous studies early cancer, are able identify rare tumors such follicular dendritic T helper 17 cells. Tumors different display heterogeneity cellular composition, chromosomal structure, developmental trajectory, intercellular signaling network phenotype dominance. Our study also reveals correlation with associated neutrophils, which might help shed light on function NSCLC.

Language: Английский

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Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes

Nature Biotechnology, Journal Year: 2021, Volume and Issue: 39(5), P. 599 - 608

Published: Jan. 18, 2021

Language: Английский

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Liver tumour immune microenvironment subtypes and neutrophil heterogeneity

Nature, Journal Year: 2022, Volume and Issue: 612(7938), P. 141 - 147

Published: Nov. 9, 2022

Language: Английский

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Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma

Journal of Hepatology, Journal Year: 2020, Volume and Issue: 73(5), P. 1118 - 1130

Published: June 5, 2020

Intrahepatic cholangiocarcinoma (ICC) is the second most common liver malignancy. ICC typically features remarkable cellular heterogeneity and a dense stromal reaction. Therefore, comprehensive understanding of diversity interplay between malignant cells niche essential to elucidate mechanisms driving progression develop therapeutic approaches.Herein, we performed single-cell RNA sequencing (scRNA-seq) analysis on unselected viable from 8 human ICCs adjacent samples transcriptomic landscape intercellular communication network. Additionally, applied negative selection strategy enrich fibroblast populations in 2 other investigate diversity. The results analyses were validated using multiplex immunofluorescence staining, bulk datasets, functional vitro vivo experiments.We sequenced total 56,871 single derived tissues identified diverse tumor, immune, cells. Malignant displayed high degree inter-tumor heterogeneity. Moreover, tumor-infiltrating CD4 regulatory T exhibited highly immunosuppressive characteristics. We 6 distinct subsets, which majority CD146-positive vascular cancer-associated fibroblasts (vCAFs), with expressed microvasculature signatures levels interleukin (IL)-6. Functional assays indicated that IL-6 secreted by vCAFs induced significant epigenetic alterations cells, particularly upregulating enhancer zeste homolog (EZH2) thereby enhancing Furthermore, cell-derived exosomal miR-9-5p elicited expression promote tumor progression.Our dataset delineates ICCs, underlining importance crosstalk vCAFs, revealing potential targets.Intrahepatic an aggressive chemoresistant Better complex transcriptional architecture these tumors will help development more effective therapies. Herein, have important interactions cancer stroma, could implications.

Language: Английский

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Identification of a tumour immune barrier in the HCC microenvironment that determines the efficacy of immunotherapy

Journal of Hepatology, Journal Year: 2023, Volume and Issue: 78(4), P. 770 - 782

Published: Jan. 26, 2023

Language: Английский

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Aspects of the Tumor Microenvironment Involved in Immune Resistance and Drug Resistance

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: May 27, 2021

The tumor microenvironment (TME) is a complex and ever-changing “rogue organ” composed of its own blood supply, lymphatic nervous systems, stroma, immune cells extracellular matrix (ECM). These components, utilizing both benign malignant cells, nurture the harsh, immunosuppressive nutrient-deficient environment necessary for cell growth, proliferation phenotypic flexibility variation. An important aspect TME cellular crosstalk cell-to-ECM communication. This interaction induces release soluble factors responsible evasion ECM remodeling, which further contribute to therapy resistance. Other aspects are presence exosomes contributed by circulating deregulated microRNAs TME-specific metabolic patterns potentiate progression and/or resistance therapy. In addition biochemical signaling, specific characteristics such as hypoxic environment, derangements, abnormal mechanical forces have been implicated in development treatment this review, we will provide an overview microenvironmental composition, structure, features that influence suppression

Language: Английский

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