Lung cancer in patients who have never smoked — an emerging disease

Nature Reviews Clinical Oncology, Journal Year: 2024, Volume and Issue: 21(2), P. 121 - 146

Published: Jan. 9, 2024

Language: Английский

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Control of stem cell renewal and fate by YAP and TAZ

Nature Reviews Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 24(12), P. 895 - 911

Published: Aug. 25, 2023

Language: Английский

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Drug-tolerant persister cells in cancer: the cutting edges and future directions

Nature Reviews Clinical Oncology, Journal Year: 2023, Volume and Issue: 20(11), P. 799 - 813

Published: Sept. 25, 2023

Language: Английский

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Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer

Cancer Cell, Journal Year: 2023, Volume and Issue: 41(8), P. 1516 - 1534.e9

Published: Aug. 1, 2023

Acquired resistance to tyrosine kinase inhibitors (TKI), such as osimertinib used treat EGFR-mutant lung adenocarcinomas, limits long-term efficacy and is frequently caused by non-genetic mechanisms. Here, we define the chromatin accessibility gene regulatory signatures of sensitive resistant cell patient-derived models uncover a role for mammalian SWI/SNF remodeling complexes in TKI resistance. By profiling mSWI/SNF genome-wide localization, identify both shared cancer line-specific targets underlying state. Importantly, genetic pharmacologic disruption SMARCA4/SMARCA2 ATPases re-sensitizes subset via inhibition mSWI/SNF-mediated regulation cellular programs governing proliferation, epithelial-to-mesenchymal transition, epithelial differentiation, NRF2 signaling. These data highlight supporting suggest potential utility TKI-resistant cancers.

Language: Английский

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Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS

Nature Cancer, Journal Year: 2023, Volume and Issue: 4(6), P. 829 - 843

Published: June 5, 2023

Language: Английский

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