Trends in cancer,
Journal Year:
2023,
Volume and Issue:
9(4), P. 309 - 325
Published: Jan. 14, 2023
T
follicular
helper
(Tfh)
cells
provide
essential
help
to
B
for
effective
antibody-mediated
immune
responses.
Although
the
crucial
function
of
these
CD4+
in
infection
and
vaccination
is
well
established,
their
involvement
cancer
only
beginning
emerge.
Increased
numbers
Tfh
cell-derived
or
cell-associated
malignancies
are
often
associated
with
an
unfavorable
outcome,
whereas
various
solid
organ
tumor
types
non-lymphocytic
origin,
presence
frequently
coincides
a
better
prognosis.
We
discuss
recent
advances
understanding
how
cell
crosstalk
CD8+
secondary
tertiary
lymphoid
structures
(TLS)
enhances
antitumor
immunity,
but
may
also
exacerbate
immune-related
adverse
events
(irAEs)
such
as
autoimmunity
during
checkpoint
blockade
(ICB)
immunotherapy.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
10(5)
Published: Dec. 18, 2022
Distant
metastasis
remains
the
major
cause
of
morbidity
for
breast
cancer.
Individuals
with
liver
or
brain
have
an
extremely
poor
prognosis
and
low
response
rates
to
anti-PD-1/L1
immune
checkpoint
therapy
compared
those
at
other
sites.
Therefore,
it
is
urgent
investigate
underlying
mechanism
resistance
develop
more
effective
immunotherapy
strategies
these
patients.
Using
single-cell
RNA
sequencing,
a
high-resolution
map
entire
tumor
ecosystem
based
on
44
473
cells
from
cancer
metastases
depicted.
Identified
by
canonical
markers
confirmed
multiplex
immunofluorescent
staining,
metastatic
features
remarkable
reprogramming
immunosuppressive
such
as
FOXP3+
regulatory
T
cells,
LAMP3+
tolerogenic
dendritic
CCL18+
M2-like
macrophages,
RGS5+
cancer-associated
fibroblasts,
LGALS1+
microglial
cells.
In
addition,
PD-1
PD-L1/2
are
barely
expressed
in
CD8+
cancer/immune/stromal
respectively.
Interactions
molecules
LAG3-LGALS3
TIGIT-NECTIN2
between
found
play
dominant
roles
escape.
summary,
this
study
dissects
intratumoral
heterogeneity
microenvironment
first
time,
providing
insights
into
most
appropriate
Cell,
Journal Year:
2023,
Volume and Issue:
186(19), P. 4235 - 4251.e20
Published: Aug. 21, 2023
Natural
killer
(NK)
cells
play
indispensable
roles
in
innate
immune
responses
against
tumor
progression.
To
depict
their
phenotypic
and
functional
diversities
the
microenvironment,
we
perform
integrative
single-cell
RNA
sequencing
analyses
on
NK
from
716
patients
with
cancer,
covering
24
cancer
types.
We
observed
heterogeneity
cell
composition
a
tumor-type-specific
manner.
Notably,
have
identified
group
of
tumor-associated
that
are
enriched
tumors,
show
impaired
anti-tumor
functions,
associated
unfavorable
prognosis
resistance
to
immunotherapy.
Specific
myeloid
subpopulations,
particular
LAMP3+
dendritic
cells,
appear
mediate
regulation
immunity.
Our
study
provides
insights
into
NK-cell-based
immunity
highlights
potential
clinical
utilities
subsets
as
therapeutic
targets.
Nature,
Journal Year:
2023,
Volume and Issue:
616(7957), P. 563 - 573
Published: April 12, 2023
Abstract
B
cells
are
frequently
found
in
the
margins
of
solid
tumours
as
organized
follicles
ectopic
lymphoid
organs
called
tertiary
structures
(TLS)
1,2
.
Although
TLS
have
been
to
correlate
with
improved
patient
survival
and
response
immune
checkpoint
blockade
(ICB),
underlying
mechanisms
this
association
remain
elusive
Here
we
investigate
lung-resident
cell
responses
patients
from
TRACERx
421
(Tracking
Non-Small-Cell
Lung
Cancer
Evolution
Through
Therapy)
other
lung
cancer
cohorts,
a
recently
established
immunogenic
mouse
model
for
adenocarcinoma
3
We
find
that
both
human
adenocarcinomas
elicit
local
germinal
centre
tumour-binding
antibodies,
further
identify
endogenous
retrovirus
(ERV)
envelope
glycoproteins
dominant
anti-tumour
antibody
target.
ERV-targeting
amplified
by
ICB
humans
mice,
targeted
inhibition
KRAS(G12C)
model.
ERV-reactive
antibodies
exert
activity
extends
model,
ERV
expression
predicts
outcome
adenocarcinoma.
Finally,
effective
immunotherapy
requires
CXCL13-dependent
formation.
Conversely,
therapeutic
CXCL13
treatment
potentiates
immunity
synergizes
ICB.
Our
findings
provide
possible
mechanistic
basis
response.
