International Journal of Biological Sciences,
Journal Year:
2022,
Volume and Issue:
18(10), P. 4101 - 4117
Published: Jan. 1, 2022
The
impact
of
the
gut
microbiome
on
host
health
is
becoming
increasingly
recognized.To
date,
there
growing
evidence
that
complex
characteristics
microbial
community
play
key
roles
as
potential
biomarkers
and
predictors
responses
in
cancer
therapy.Many
studies
have
shown
altered
commensal
bacteria
lead
to
susceptibility
progression
diverse
pathways.In
this
review,
we
critically
assess
data
for
microbiota
related
gastrointestinal
cancer,
including
esophageal,
gastric,
pancreatic,
colorectal
hepatocellular
carcinoma
cholangiocarcinoma.Importantly,
underlying
mechanisms
involved
occurrence,
prevention
treatment
are
elucidated.The
purpose
review
provide
novel
insights
applying
understanding
development
new
therapeutic
strategies
by
targeting
community.
Cell,
Journal Year:
2022,
Volume and Issue:
185(20), P. 3789 - 3806.e17
Published: Sept. 1, 2022
Cancer-microbe
associations
have
been
explored
for
centuries,
but
cancer-associated
fungi
rarely
examined.
Here,
we
comprehensively
characterize
the
cancer
mycobiome
within
17,401
patient
tissue,
blood,
and
plasma
samples
across
35
types
in
four
independent
cohorts.
We
report
fungal
DNA
cells
at
low
abundances
many
major
human
cancers,
with
differences
community
compositions
that
differ
among
types,
even
when
accounting
technical
background.
Fungal
histological
staining
of
tissue
microarrays
supported
intratumoral
presence
frequent
spatial
association
macrophages.
Comparing
communities
matched
bacteriomes
immunomes
revealed
co-occurring
bi-domain
ecologies,
often
permissive,
rather
than
competitive,
microenvironments
distinct
immune
responses.
Clinically
focused
assessments
suggested
prognostic
diagnostic
capacities
mycobiomes,
stage
I
synergistic
predictive
performance
bacteriomes.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Jan. 16, 2023
Abstract
Microorganisms,
including
bacteria,
viruses,
fungi,
and
other
eukaryotes,
play
critical
roles
in
human
health.
An
altered
microbiome
can
be
associated
with
complex
diseases.
Intratumoral
microbial
components
are
found
multiple
tumor
tissues
closely
correlated
cancer
initiation
development
therapy
efficacy.
The
intratumoral
microbiota
may
contribute
to
promotion
of
the
progression
cancers
by
DNA
mutations,
activating
carcinogenic
pathways,
promoting
chronic
inflammation,
complement
system,
initiating
metastasis.
Moreover,
not
only
enhance
antitumor
immunity
via
mechanisms
STING
signaling
activation,
T
NK
cell
TLS
production,
microbiota-derived
antigen
presenting,
but
also
decrease
immune
responses
promote
through
pathways
upregulation
ROS,
an
anti-inflammatory
environment,
inactivation,
immunosuppression.
effect
on
is
dependent
composition,
crosstalk
between
cancer,
status
cancers.
regulate
physiology
response
different
β-catenin,
TLR,
ERK,
NF-κB,
STING,
among
others.
These
viewpoints
help
identify
as
diagnosis
or
prognosis
evaluation
cancers,
new
therapeutic
strategy
potential
targets
for
therapy.
Science,
Journal Year:
2023,
Volume and Issue:
380(6645)
Published: May 11, 2023
The
response
to
tumor-initiating
inflammatory
and
genetic
insults
can
vary
among
morphologically
indistinguishable
cells,
suggesting
as
yet
uncharacterized
roles
for
epigenetic
plasticity
during
early
neoplasia.
To
investigate
the
origins
impact
of
such
plasticity,
we
performed
single-cell
analyses
on
normal,
inflamed,
premalignant,
malignant
tissues
in
autochthonous
models
pancreatic
cancer.
We
reproducibly
identified
heterogeneous
cell
states
that
are
primed
diverse,
late-emerging
neoplastic
fates
linked
these
chromatin
remodeling
at
cell-cell
communication
loci.
Using
an
inference
approach,
revealed
signaling
gene
modules
tissue-level
cross-talk,
including
a
neoplasia-driving
feedback
loop
between
discrete
epithelial
immune
populations
was
functionally
validated
mice.
Our
results
uncover
neoplasia-specific
tissue-remodeling
program
may
be
exploited
cancer
interception.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Jan. 10, 2024
Abstract
Human
microorganisms,
including
bacteria,
fungi,
and
viruses,
play
key
roles
in
several
physiological
pathological
processes.
Some
studies
discovered
that
tumour
tissues
once
considered
sterile
actually
host
a
variety
of
which
have
been
confirmed
to
be
closely
related
oncogenesis.
The
concept
intratumoural
microbiota
was
subsequently
proposed.
Microbiota
could
colonise
through
mucosal
destruction,
adjacent
tissue
migration,
hematogenic
invasion
affect
the
biological
behaviour
tumours
as
an
important
part
microenvironment.
Mechanistic
demonstrated
potentially
promote
initiation
progression
by
inducing
genomic
instability
mutations,
affecting
epigenetic
modifications,
promoting
inflammation
response,
avoiding
immune
regulating
metabolism,
activating
metastasis.
Since
more
comprehensive
profound
insights
about
intratumoral
are
continuously
emerging,
new
methods
for
early
diagnosis
prognostic
assessment
cancer
patients
under
examination.
In
addition,
interventions
based
on
show
great
potential
open
chapter
antitumour
therapy,
especially
immunotherapy,
although
there
some
inevitable
challenges.
Here,
we
aim
provide
extensive
review
concept,
development
history,
sources,
heterogeneity,
carcinogenic
mechanisms
explore
role
microorganisms
prognosis,
discuss
current
treatment
regimens
target
research
prospects
limitations
this
field.
