Modern Pathology, Journal Year: 2024, Volume and Issue: unknown, P. 100674 - 100674
Published: Nov. 1, 2024
Language: Английский
Current Opinion in Oncology, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 4, 2024
This review aims to provide an overview of recent advances in immunotherapy for small cell lung cancer (SCLC), with a focus on the current status immune checkpoint inhibitors (ICIs), novel combination strategies, and key biomarkers.
Language: Английский
Citations
2
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 15, 2024
Summary paragraph Neuroendocrine and tuft cells are rare, chemosensory epithelial lineages defined by expression of ASCL1 POU2F3 transcription factors, respectively 1,2 . cancers, including small cell lung cancer (SCLC), frequently display tuft-like subsets, a feature linked to poor patient outcomes 3–13 The mechanisms driving neuroendocrine–tuft tumour heterogeneity, the origins cancers unknown. Using multiple genetically-engineered animal models SCLC, we demonstrate that basal origin (but not accepted neuroendocrine origin) generates neuroendocrine–tuft-like tumours highly recapitulate human SCLC. Single-cell clonal analyses basal-derived SCLC further uncovers unexpected transcriptional states lineage trajectories underlying plasticity. Uniquely in cells, introduction genetic alterations enriched high MYC, PTEN loss, suppression, cooperate promote tumours. Transcriptomics 944 SCLCs reveal basal-like subset tuft-ionocyte-like state altogether remarkable conservation between normal injury response 14–18 Together, these data suggest is plausible for other neuroendocrine-tuft can explain heterogeneity—offering new insights targeting
Language: Английский
Citations
2
Cancer Cell, Journal Year: 2024, Volume and Issue: 42(8), P. 1326 - 1328
Published: Aug. 1, 2024
Language: Английский
Citations
1
The American Journal of Surgical Pathology, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 25, 2024
Epithelial chemosensory cells in hollow organs, also known as tuft cells, were implicated tumorigenesis, including a cell-like small cell lung carcinoma. Expression of the POU2F3 transcription factor is marker lineage. However, development, differentiation, and proliferation are controlled by expression complex formed POU2AF2 or POU2AF3 transcriptional coactivators. A cohort epithelial (n=6064) mesenchymal/neuroectodermal (n=2730) tumors was screened for immunohistochemistry. Variable immunoreactivity ranging from diffuse to scattered positive found ∼12.4% 4.6% tumors. Cases with predominantly patchy positivity representing various types malignant (n=43) selected further study, Thirteen 15 neuroendocrine differentiation originating lung, colon, head neck, skin, bladder revealed positivity. Most those (n=9) co-expressed POU2AF2, usually extensively. Seven squamous basal carcinomas oral cavity, thymus immunostaining except one, lacked expression. Other variably POU2F3-positive (n=13) pancreas, liver, kidney, testis, endometrium, ovary, breast immunoreactivity. All mesenchymal neuroectodermal (n=8), synovial sarcoma, solitary fibrous tumor, glioblastoma, Wilms melanoma POU2AF2-negative. highly sensitive but nonspecific indicator differentiation. Co-expression appears be more specific marker, although it may not pinpoint driven POU2F3-POU2AF3 complex.
Language: Английский
Citations
0
The Nucleus, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 10, 2024
Language: Английский
Citations
0
Modern Pathology, Journal Year: 2024, Volume and Issue: unknown, P. 100674 - 100674
Published: Nov. 1, 2024
Language: Английский
Citations
0