Resistance to Immunotherapy in Non-small Cell Lung Cancer: Unraveling Causes, Developing Effective Strategies, and Exploring Potential Breakthroughs

Drug Resistance Updates, Journal Year: 2025, Volume and Issue: 81, P. 101215 - 101215

Published: Feb. 26, 2025

Language: Английский

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Inducing Cuproptosis with Copper Ion‐Loaded Aloe Emodin Self‐Assembled Nanoparticles for Enhanced Tumor Photodynamic Immunotherapy

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Immunotherapy has fundamentally transformed the clinical treatment landscape for non-small cell lung cancer (NSCLC). While its effectiveness is ultimately limited by patient heterogeneity and immunosuppressive tumor microenvironment. Photodynamic therapy (PDT), as an emerging antitumor immunotherapy, shown unique therapeutic advantages. However, previous studies often overlooked potential toxicity of photosensitizers (PS), making discovery safe effective PS a pressing need. In this study, Aloe Emodin (AE), medicinal plant natural compound, was loaded with copper ions (Cu), self-assembled into nanoparticles (NPs) under modification PEG2k-DSPE-FA. NPs can target, accumulate, reside within sites, responsively releasing AE, thus dual-functioning inducing death via cuproptosis enhancing PDT effects. The LLC tumor-bearing mouse model demonstrated that induce maturation dendritic cells (DCs) in vivo, promote lymphocyte infiltration, transform "cold tumors" "hot significantly enhance efficacy immune checkpoint blockade (ICB). This study provides experimental evidence AE clinically promising agent offers novel perspective synergistic NSCLC.

Language: Английский

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Predicting colorectal adenoma recurrence: the role of systemic inflammatory markers and insulin resistance

Scandinavian Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 7

Published: Feb. 26, 2025

Colorectal adenomas (CRA) exhibit high recurrence rates following endoscopic resection. Insulin resistance (IR) and chronic inflammation, increasingly prevalent due to unhealthy lifestyles, are key factors in CRA development. This study aimed evaluate the predictive power of combining inflammation score with triglyceride-glucose (TyG) index for recurrence. We conducted a comprehensive analysis clinical characteristics 847 patients who underwent Postoperative was assessed using logistic regression analyses determine odds ratios (ORs) 95% confidence intervals (CIs). The receiver operating characteristic (ROC) curve utilized predict risk based on TyG index. Among included study, 126 experienced recurrences. Logistic identified NLR (OR 2.641, CI 1.982-3.549), 1.494, 1.146-1.956), three or more 2.182, 1.431-3.322) larger than 10 mm 1.917, 1.267-2.921) as independent ROC curves demonstrated efficacy (AUC 0.701, 0.652-0.750) 0.607, 0.553-0.660) predicting combination NLR, adenoma showed improved performance 0.762, 0.718-0.805). Elevated were associated an increased integration significantly enhanced

Language: Английский

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T cell exhaustion: early or late in tumour progression?

Nature reviews. Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

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CD47 as a potent target in cancer immunotherapy: A review

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: 1880(2), P. 189294 - 189294

Published: March 6, 2025

Language: Английский

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