Mitochondria in focus: From structure and function to their role in human diseases. A review DOI Creative Commons

Daniel Follprecht,

Jakub Vavricka,

Viktorie Johankova

et al.

Biomedical Papers, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Mitochondria, double-membraned organelles within all eukaryotic cells, are essential for the proper functioning of human organism. The frequently used phrase "powerhouses cell" fails to adequately capture their multifaceted roles. In addition producing energy in form adenosine triphosphate through oxidative phosphorylation, mitochondria also involved apoptosis (programmed cell death), calcium regulation, and signaling reactive oxygen species. Recent research suggests that they can communicate with one another influence cellular processes. Impaired mitochondrial function on hand, have widespread profound effects organismal health, contributing various diseases age-related conditions. Regular exercise other promotes health by enhancing volume, density, functionality. Although has made significant progress last few decades, mainly use modern technologies, there is still a need intensify efforts this field. Exploring new approaches enhance could potentially impact longevity. review, we focus discoveries, examine structure diverse roles body, explore metabolism emphasize importance maintaining overall health.

Language: Английский

Mitochondria in focus: From structure and function to their role in human diseases. A review DOI Creative Commons

Daniel Follprecht,

Jakub Vavricka,

Viktorie Johankova

et al.

Biomedical Papers, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Mitochondria, double-membraned organelles within all eukaryotic cells, are essential for the proper functioning of human organism. The frequently used phrase "powerhouses cell" fails to adequately capture their multifaceted roles. In addition producing energy in form adenosine triphosphate through oxidative phosphorylation, mitochondria also involved apoptosis (programmed cell death), calcium regulation, and signaling reactive oxygen species. Recent research suggests that they can communicate with one another influence cellular processes. Impaired mitochondrial function on hand, have widespread profound effects organismal health, contributing various diseases age-related conditions. Regular exercise other promotes health by enhancing volume, density, functionality. Although has made significant progress last few decades, mainly use modern technologies, there is still a need intensify efforts this field. Exploring new approaches enhance could potentially impact longevity. review, we focus discoveries, examine structure diverse roles body, explore metabolism emphasize importance maintaining overall health.

Language: Английский

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