Progress in Catalytic Asymmetric Reactions with 7-Azaindoline as the Directing Group DOI Creative Commons
Yanping Zhang, Yong You,

Jun‐Qing Yin

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(23), P. 7898 - 7898

Published: Dec. 1, 2023

α-Substituted-7-azaindoline amides and α,β-unsaturated 7-azaindoline have emerged as new versatile synthons for various metal-catalyzed organic-catalyzed asymmetric reactions, which attracted much attention from chemists. In this review, the progress of research on in aldol reaction, Mannich conjugate addition, 1,3-dipole cycloaddition, Michael/aldol cascade aminomethylation Michael addition-initiated ring-closure reaction is discussed. The α-substituted-7-azaindoline amides, nucleophiles, are classified according to type α-substituted group, whereas electrophiles, reaction.

Language: Английский

Dearomative spiroannulation of indoles enabled by the diaza-[1,2]-Wittig rearrangement DOI

Can Luo,

Chun-Yan Guan,

Zhenyu Li

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(6), P. 1685 - 1691

Published: Jan. 1, 2024

Reported herein is the first diaza-[1,2]-Wittig rearrangement-enabled dearomative spiroannulation reaction of indoles. This protocol features metal-free conditions, a redox-neutral process, broad substrate scope, and good yield.

Language: Английский

Citations

1
A kinetic resolution accompanied chirality transformation process for asymmetric synthesis of chiral phenol, oxaziridine, and α-hydroxyl cyclic ketone DOI
Pengxin Wang, Xiaoyong Zhang, Lingqing Wang

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(9), P. 2989 - 2997

Published: Aug. 8, 2024

Language: Английский

Citations

1
Harnessing Dpp-Imine as a Powerful Achiral Cocatalyst to Dramatically Increase the Efficiency and Stereoselectivity in a Magnesium-Mediated Oxa-Michael Reaction DOI Creative Commons

Yingfan Xu,

Dan Liu,

Feiyun Gao

et al.

JACS Au, Journal Year: 2023, Volume and Issue: 4(1), P. 164 - 176

Published: Dec. 21, 2023

Dpp-imines are classic model substrates for synthetic method studies. Here, we disclose their powerful use as achiral coligands in metal-catalyzed reactions. It is highly interesting to find that the Dpp-imine can not only act ligand create excellent chiral pockets with magnesium complexes but also, more importantly, this coligand dramatically enhance catalytic ability of metal catalyst. The underlying reaction mechanism was extensively explored by conducting a series experiments, including

Language: Английский

Citations

3
Magnesium catalyzed asymmetric ring-opening reactions of high-strained three membered cyclic systems DOI

Jiaming Lü,

Linqing Wang,

Rui Wang

et al.

Chinese Science Bulletin (Chinese Version), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 1, 2023

Language: Английский

Citations

3
Take Advantage of the N‐Nucleophilicity of Imine in Catalytic Cyclization Reactions DOI
Linqing Wang, Dongxu Yang

ChemCatChem, Journal Year: 2023, Volume and Issue: 15(9)

Published: March 10, 2023

Abstract Imines, or Schiff bases are basic and important synthons in modern chemical synthesis, which widely used methodological studies, synthesis of natural products pharmaceutical agents, construction organic porous materials relative late‐stage modifications. In most cases, the imines often act as “electrophilic reagents” reactions on basis their C‐electrophilicity owing to dipole effect C=N bond. However, other hand, initiated by N‐nucleophilicity imine, draw relatively less attentions. this concept article, we try give a concise summary reactions, especially cyclization reaction that imine. The measurement data discussions different imines, possible mechanisms, catalytic strategies, types context briefly discussed. We hope one will be utilized broader scope future taking advantage N‐nucleophilicity.

Language: Английский

Citations

2
Progress in Catalytic Asymmetric Reactions with 7-Azaindoline as the Directing Group DOI Creative Commons
Yanping Zhang, Yong You,

Jun‐Qing Yin

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(23), P. 7898 - 7898

Published: Dec. 1, 2023

α-Substituted-7-azaindoline amides and α,β-unsaturated 7-azaindoline have emerged as new versatile synthons for various metal-catalyzed organic-catalyzed asymmetric reactions, which attracted much attention from chemists. In this review, the progress of research on in aldol reaction, Mannich conjugate addition, 1,3-dipole cycloaddition, Michael/aldol cascade aminomethylation Michael addition-initiated ring-closure reaction is discussed. The α-substituted-7-azaindoline amides, nucleophiles, are classified according to type α-substituted group, whereas electrophiles, reaction.

Language: Английский

Citations

1