Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 30, 2024
A
visible-light
induced
intermolecular
hydroamination
of
alkenes
with
azoles
is
reported,
delivering
pharmaceutically
valuable
N-benzyl
in
high
yields
excellent
Markovnikov
selectivity.
Mechanistic
studies
suggest
that
the
process
initiated
by
energy
transfer
excited
photocatalyst
alkenes,
followed
single
electron
reduction,
protonation,
and
subsequent
oxidation
to
afford
key
alkyl
carbocation
intermediate.
This
protocol
exhibits
advantages
broad
functional
group
tolerance,
atom
economy,
efficiency,
mild
reaction
conditions.
ChemCatChem,
Journal Year:
2024,
Volume and Issue:
16(20)
Published: June 27, 2024
Abstract
Herein,
a
method
for
the
assembly
of
biologically
valuable
3‐selenospiro[4,5]decatrienones
through
CuBr
2
‐catalyzed
ispo
‐cyclization
Se
powder,
boronic
acids,
and
N
‐(
p
‐methoxyaryl)propiolamides
has
been
established.
In
this
protocol,
noble
transition
metal,
prefunctionalized
selenylation
reagent,
strong
chemical
oxidant
are
not
employed.
This
feature
wide
substrate
scope,
good
functional
group
tolerance,
easy
operation,
employing
earth‐abundant
metal
as
catalyst
green
air
oxidant.
Furthermore,
several
derivatizations
performed
to
showcase
practicability
our
strategy.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(15), P. 11083 - 11087
Published: July 24, 2024
A
novel
approach
for
the
acylation
of
azauracil
derivatives
with
aldehydes
has
been
developed
utilizing
sodium
decatungstate
(NaDT)
as
a
photocatalyst.
This
method
demonstrates
broad
substrate
tolerance
and
yields
moderate
to
excellent
outcomes.
Notably,
it
aligns
green
chemistry
principles
by
eliminating
oxidants,
eco-friendly
energy
sources,
offering
high
scalability
operational
simplicity.
Abstract
An
expedient
strategy
for
the
construction
of
trifluoromethylselenolated
spiro[5.5]trienones/spiro[4.5]trienones
through
a
cascade
electrophilic
trifluoromethylselenolation
cyclization
and
dearomatization
has
been
developed.
This
sequential
process
was
induced
by
N
‐trifluoromethylselenophthalimide
(Phth‐SeCF
3
),
which
an
efficient
reagent.
approach
feature
mild
conditions,
broad
substrate
scope,
high
functional
group
tolerance.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 30, 2024
A
visible-light
induced
intermolecular
hydroamination
of
alkenes
with
azoles
is
reported,
delivering
pharmaceutically
valuable
N-benzyl
in
high
yields
excellent
Markovnikov
selectivity.
Mechanistic
studies
suggest
that
the
process
initiated
by
energy
transfer
excited
photocatalyst
alkenes,
followed
single
electron
reduction,
protonation,
and
subsequent
oxidation
to
afford
key
alkyl
carbocation
intermediate.
This
protocol
exhibits
advantages
broad
functional
group
tolerance,
atom
economy,
efficiency,
mild
reaction
conditions.
