Synlett,
Journal Year:
2023,
Volume and Issue:
34(17), P. 2022 - 2028
Published: June 7, 2023
Abstract
A
general
and
efficient
three-component
protocol
for
the
synthesis
of
isoxazolidines
has
been
developed.
range
nitrosoarenes,
olefins,
as
well
iodonium
ylides
can
be
subjected
to
this
reaction
generate
N-aryl
derivatives
with
moderate
excellent
yields.
In
addition,
we
demonstrate
that
approach
employs
1,3-dipolar
cycloaddition
nitrones
generated
in
situ
from
nitroso
compounds,
olefins
absence
any
catalysts
additives.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(16), P. 2125 - 2136
Published: Jan. 1, 2024
In
this
feature
article,
we
focus
on
the
photochemical
strategy
for
construction
of
heterocyclic
skeletons,
specifically
highlighting
methods
that
employ
visible
light-promoted
carbene
transfer
reactions.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(12), P. 2511 - 2516
Published: March 20, 2024
This
work
demonstrates
the
synthesis
of
a
variety
perfluoroalkyl
heterocycles
via
visible-light-driven
radical-polar
crossover
cyclization
strategy.
In
this
process,
single-electron
reduction/SNV-type/cyclization
sequences
follow
radical
addition
reaction
diazoester,
which
differs
from
current
role
diazoesters
as
precursors/acceptors.
transformation
excellent
functional
group
compatibility
and
allows
for
modification
many
bioactive
molecules
with
diazoesters.
Such
could
represent
novel
approach
to
photochemical
diazo
compounds.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(7), P. 1393 - 1398
Published: Feb. 12, 2024
We
disclose
herein
a
photocatalytic
radical
cascade
cyclization
of
diazoalkanes
for
the
divergent
synthesis
important
carbocycles
and
heterocycles.
Under
optimal
reaction
conditions,
various
indanone,
pyrone,
pyridinone
derivatives
can
be
obtained
in
moderate
to
good
yields.
Mechanistic
experiments
support
formation
carbon-centered
radicals
from
through
proton-coupled
electron
transfer
process.
Scale-up
using
continuous
flow
technology
useful
downstream
application
formed
heterocycles
further
render
strategy
attractive
valuable.
The
multi-component
ring-opening
reactions
of
cyclic
ethers
offer
an
efficient
strategy
for
the
rapid
introduction
multiple
functional
groups
and
construction
complex
molecular
architectures.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 22, 2025
In
this
study,
we
devised
an
innovative
approach
for
the
synthesis
of
pyrazine
derivatives
through
a
photoinduced
formal
cross-[3+3]
cycloaddition
between
vinyldiazo
reagents
and
acceptor-only
diazoalkanes.
This
method
leverages
differential
reactivity
two
distinct
diazo
compounds:
reagents,
which
upon
visible
light
irradiation
form
key
cyclopropane
intermediates,
diazoalkanes,
function
as
1,3-dipoles
to
capture
photogenerated
reactive
species.
The
reactions
proceed
exclusively
under
light,
yielding
1,4-dihydropyridazines
with
broad
substrate
scope
compatibility
various
functional
groups.
Importantly,
synthesized
can
be
readily
converted
other
valuable
products.
mechanism,
elucidated
UV–vis
absorption
studies,
deuterium
labeling
experiments,
control
in
situ
NMR
spectroscopy,
provides
clear
understanding
observed
reactivity.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(19), P. 4031 - 4036
Published: Jan. 26, 2024
We
present
a
new
[3+2]
cycloaddition
reaction
between
alkyl-acceptor
diazoalkanes
under
visible
light
irradiation.
By
employing
easily
accessible
alkyl-acceptor-type
or
their
precursor
hydrazones
as
both
1,3-dipoles
and
dipolarophiles,
diverse
range
of
pyrazoline
derivatives
featuring
quaternary
center
have
been
efficiently
synthesized
in
predictable
manner,
with
excellent
functional
group
tolerance
good
yields.
Furthermore,
scale-up
experiments
downstream
transformations
the
product
were
also
detailed.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(8), P. 1833 - 1839
Published: Feb. 8, 2024
Abstract
Herein,
we
report
a
photochemical
synthesis
of
1,4‐dicarbonyl
containing
quinoxalin‐2(1
H
)‐ones
through
consecutive
photoredox
catalysed
reactions.
A
wide
range
C3‐modified
were
obtained
in
53–91%
yields
by
this
approach.
Mechanistic
studies
including
radical
trapping,
EPR
studies,
D‐labelling
investigations,
and
many
other
control
experiments
well
explained
the
proposed
mechanism.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(27), P. 5827 - 5832
Published: July 2, 2024
We
disclosed
herein
an
enantioselective
formal
siloxycarbene
insertion
reaction
enabled
by
chiral
phosphoric
acid
and
blue
LED
irradiation.
This
is
the
first
time
asymmetric
into
sp
Tetrahedron Chem,
Journal Year:
2023,
Volume and Issue:
7, P. 100040 - 100040
Published: June 16, 2023
Herein,
we
developed
a
mild
and
efficient
photoredox-enabled
remote
radical
group
migration
with
the
utilization
of
diazoalkanes
as
precursors,
giving
access
to
various
valuable
1,7-dicarbonlys
in
moderate
good
yields.
A
diverse
set
migrating
groups,
including
benzothiazole,
benzothiophene,
pyrazine,
pyridine,
thiazole,
thiophene
nitrile
were
well
tolerated.
Furthermore,
facile
synthesis
1,8-dicarbonyl
compound,
scale-up
reaction
useful
synthetic
transformation
further
proved
method
attractive
valuable.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(16), P. 9104 - 9109
Published: Jan. 1, 2024
A
green
and
efficient
method
for
the
synthesis
of
glycine
derivatives
from
amines,
azodicarboxylates,
diazoalkanes
has
been
developed.
This
multicomponent
reaction
occurred
under
mild
conditions
in
absence
any
catalysts
or
additives.
