Lipid nanoparticle-based delivery of small interfering RNAs: New possibilities in the treatment of diverse diseases DOI
Anis Askarizadeh,

Fatemeh Vahdat‐Lasemi,

Sercan Karav

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: unknown, P. 113624 - 113624

Published: Dec. 1, 2024

Language: Английский

Targeted delivery systems of siRNA based on ionizable lipid nanoparticles and cationic polymer vectors DOI
Zhao Yao,

Taiqing Liu,

Jingwen Wang

et al.

Biotechnology Advances, Journal Year: 2025, Volume and Issue: 81, P. 108546 - 108546

Published: Feb. 26, 2025

Language: Английский

Citations

2
Angelica sinensis polysaccharides modified selenium nanoparticles for effective prevention of acute liver injury DOI
Yu Xu,

Xinchuang Wang,

Wen Jiang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 263, P. 130321 - 130321

Published: Feb. 20, 2024

Language: Английский

Citations

13
Role of size, surface charge, and PEGylated lipids of lipid nanoparticles (LNPs) on intramuscular delivery of mRNA DOI Creative Commons
Weiwen Kong,

Yuning Wei,

Zirong Dong

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 11, 2024

Language: Английский

Citations

11
Nose-to-brain delivery of targeted lipid nanoparticles as two-pronged β-amyloid nanoscavenger for Alzheimer’s disease therapy DOI Creative Commons

Yanyan Xu,

X W Ye,

Yanfeng Du

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
A nasally administrated reactive oxygen species-responsive carrier-free gene delivery nanosystem for Alzheimer's disease combination therapy DOI

Yongke Chen,

Xiaotong Yang, Jie Li

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113604 - 113604

Published: March 1, 2025

Language: Английский

Citations

0
Tumor Suppressor Protein-Inspired Peptide for siRNA Delivery and Synergistic Cancer Therapy DOI Creative Commons

Julien Milon Essola,

Haiyin Yang,

Wenjing Liu

et al.

Fundamental Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Nose‐to‐Brain Delivery of Circular RNA SCMH1‐Loaded Lipid Nanoparticles for Ischemic Stroke Therapy DOI Open Access

Yanpeng Jia,

Xu Lian,

Shuo Leng

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Ischemic stroke represents one of the leading cerebrovascular diseases with a high rate mortality and disability globally. To date, there are no effective clinical drugs available to improve long-term outcomes for post-stroke patients. A novel nucleic acid agent circSCMH1 which can promote sensorimotor function recovery in rodent nonhuman primate animal models has been found. However, still delivery challenges overcome its implementation. Besides, effects on cognitive functions remain unexplored. Herein, lipid nanoparticle circSCMH1@LNP1 is established deliver explore therapeutic efficacy comprehensively. Distribution experiments demonstrate that intranasal administration significantly increases distribution peri-infarct region reduces non-specific accumulation other organs compared intravenous injection. Therapeutic results indicate promotes synaptic plasticity, vascular repair, neuroinflammation relief, myelin sheath formation, thereby achieving enhanced mice. In conclusion, this research presents simple LNP system efficient via repair brain injury. It envisioned study may bridge crucial gap between basic translational application, paving way implementation patient management.

Language: Английский

Citations

0
Tumor‐Selective Gene Therapy: Using Hairpin DNA Oligonucleotides to Trigger Cleavage of Target RNA by Endogenous flap endonuclease 1 (FEN 1) Highly Expressed in Tumor Cells DOI Open Access
Chunlu Wang, Chen Wang, Chijie Xiao

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Abstract Nucleic acid drugs, which trigger gene silencing by hybridizing with target genes, have shown great potential in targeting those undruggable targets. However, most of the existing nucleic drugs are only sequence specific for genes and lack cellular or tissue selectivity, challenges their therapeutic safety. Here, study proposes a tumor cell‐specific strategy using hairpin DNA oligonucleotides to RNA degrading highly expressed endogenous flap endonuclease 1 (FEN1) cells, selective therapy. Using Kirsten rat sarcoma viral oncogene homolog ( KRAS G12S ) B‐cell lymphoma 2 Bcl‐2) as targets, it is verified that show cytotoxicity cells but very low effects on normal cells. In addition, designed inhibition, encapsulated lipid nanoparticles, inhibit growth mice demonstrate excellent antitumor efficacy combination gefitinib, has little effect tissues, suggesting proposed enables therapy give rise new class drugs.

Language: Английский

Citations

0
Self-degradable “gemini-like” ionizable lipid-mediated delivery of siRNA for subcellular-specific gene therapy of hepatic diseases DOI Creative Commons
Qiu Wang,

Bin Wan,

Feng Yao

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Polyphenol-enriched Penthorum chinense Pursh ameliorates alcohol-related liver injury through Ras/Raf/MEK/ERK pathway: Integrating network pharmacology and experiment validation DOI
Rui Li, Ding‐Tao Wu, Jianping Hu

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 321, P. 117513 - 117513

Published: Nov. 29, 2023

Language: Английский

Citations

7