Pd-, Cu-, and Ni-Catalyzed Reactions: A Comprehensive Review of the Efficient Approaches towards the Synthesis of Antibacterial Molecules DOI Creative Commons

Almeera Zia,

Shehla Khalid, Nasır Rasool

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1370 - 1370

Published: Oct. 15, 2024

A strong synthetic tool for many naturally occurring chemicals, polymers, and pharmaceutical substances is transition metal-catalyzed synthesis. serious concern to human health the emergence of bacterial resistance a broad spectrum antibacterial medications. The synthesis chemical molecules that are potential candidates underway. main contributions medicine found be effective in metal catalysis heterocyclic chemistry. This review underlines use heterocycles certain metals (Pd, Cu, Ni) as catalysts methods compounds. Pharmaceutical chemists might opt clinical exploration these techniques due their potential.

Language: Английский

1,3,4-Oxadiazole Sulfonamide Derivatives Containing Pyrazole Structures: Design, Synthesis, Biological Activity Studies, and Mechanism Study DOI

Xiaoli Ren,

Youhua Liu,

Fa‐li Wang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Sulfonamide derivatives have been widely used for pesticide research in recent years. Herein, 1,3,4-oxadiazole sulfonamide containing a pyrazole structure were synthesized, and their structure-activity relationship was studied. Bioactivity tests showed the remarkable efficacy of most synthesized compounds. Especially Xanthomonas oryzae pv oryzae, A23 exhibited 100% inhibition at 100 mg/L, surpassing bismerthiazol (99.3%), 90% 50 outperforming thiodiazole copper (84.5%), with an EC50 5.0 markedly more active than (23.9 mg/L) (63.5 mg/L). Initial investigations into antimicrobial mechanisms involved series biochemical analyses, including bacterial growth rate analysis, scanning electron microscopy, biofilm formation experiments, molecular docking analyses. Notably, considerably inhibited Xoo biofilms, disrupting integrity cell membranes. Co-analysis transcriptomics proteomics revealed capability to regulate pathways such as tryptophan metabolism phenylpropanoid biosynthesis, enhancing innate immunity rice activating its disease resistance. Thus, emerges potential immunoinducible lead compound discovery highly immune-inducing agents.

Language: Английский

Citations

0
Copper-Catalyzed Regioselective 1,4-Sulfonyl Indolylation of 1,3-Dienes with Sulfonyl Chloride and Indoles DOI
Pu Chen, Lin Tian, Xiaochen Ji

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

A copper-based catalytic system has been described to enable the efficient 1,4-sulfonylindolylation of 1,3-dienes with sulfonyl chloride and indoles. This protocol offers a practical method for synthesis allylsulfone-containing indole derivatives broad range compatible functionalities excellent chemo- regioselectivities. Mechanistic studies suggest that copper catalyst plays dual role initiating radicals prompting coupling in this conjugated diene-selective 1,4-difunctionalization strategy.

Language: Английский

Citations

0
Cobalt(III) Complexes of Pyridine-Functionalized Chelating NHC Ligands: Effective Catalysts for the Olefination of Alcohols Using Sulfones DOI

Misba Siddique,

Mehali Das,

Arnab Rit

et al.

Organometallics, Journal Year: 2024, Volume and Issue: 43(13), P. 1482 - 1489

Published: June 26, 2024

Several air-stable cobalt(III) complexes 1a-d featuring pyridine-functionalized NHC ligand systems were synthesized and completely characterized. These then explored as phosphine-free catalysts for the olefination of alcohols with sulfones, among studied here, benzimidazolylidene-supported 1b complex acetylacetonate (acac) a labile co-ligand was noted to be most active one, which also successful broad range sulfones providing diverse olefins. It is important mention that this first example such protocol catalyzed by cobalt. Furthermore, utility present demonstrated gram-scale reaction postsynthetic modifications obtained compounds. Finally, based on various control experiments including detection intermediates kinetic studies, plausible mechanism proposed.

Language: Английский

Citations

3
Smart β-cyclodextrin-dominated helical supramolecular dendritic assemblies improve the foliar affinity and biofilm disruption for treating alarming bacterial diseases DOI

Xiaoxue Tian,

Hongsheng Hu, Lijun Fan

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 348, P. 122823 - 122823

Published: Oct. 9, 2024

Language: Английский

Citations

1
Pd-, Cu-, and Ni-Catalyzed Reactions: A Comprehensive Review of the Efficient Approaches towards the Synthesis of Antibacterial Molecules DOI Creative Commons

Almeera Zia,

Shehla Khalid, Nasır Rasool

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1370 - 1370

Published: Oct. 15, 2024

A strong synthetic tool for many naturally occurring chemicals, polymers, and pharmaceutical substances is transition metal-catalyzed synthesis. serious concern to human health the emergence of bacterial resistance a broad spectrum antibacterial medications. The synthesis chemical molecules that are potential candidates underway. main contributions medicine found be effective in metal catalysis heterocyclic chemistry. This review underlines use heterocycles certain metals (Pd, Cu, Ni) as catalysts methods compounds. Pharmaceutical chemists might opt clinical exploration these techniques due their potential.

Language: Английский

Citations

0