Construction of a novel isopinocamphone-based fluorescent probe for rapid and specific detection of ClO‒ and its application in environmental analysis and biological imaging DOI
Qian Ye, Kai Xu, Zhiyuan Meng

et al.

New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 48(32), P. 14182 - 14190

Published: Jan. 1, 2024

A “turn on” fluorescent probe DMTI was designed for the detection of ClO − based on isopinocamphone.

Language: Английский

De Novo Design of a Highly Stable Ratiometric Probe for Long-Term Continuous Imaging of Endogenous HClO Burst DOI
Wenqiang Chen,

Wenju Xu,

Jiayi Xing

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(10), P. 4129 - 4137

Published: March 4, 2024

Long-term continuous imaging of endogenous HClO burst is great importance for the elucidation various physiological or pathological processes. However, most currently reported probes have failed to achieve this goal due their insufficient photobleaching resistance under a laser source. Herein, highly stable ratiometric probe, HFTC-HClO 1, which capable continuously monitoring over long period time, has been judiciously developed. Briefly, de novo development 1 mainly involved three main steps: (1) novel coumarins (HFTC 1–5) were designed and synthesized; (2) scaffold, HFTC 3, was selected through dye screening cell validation; (3) based on candidate constructed, finally its superior sensing properties toward HClO. Furthermore, can quantitatively measure levels in real samples with excellent recovery (>90.4%), use 1-coated test strips qualitative analysis also achieved. In addition, application long-term intracellular successfully demonstrated. Significantly, able visualize generated rheumatoid arthritis mouse model.

Language: Английский

Citations

10
Highly Selective AIEgen‐Based “Turn On” Fluorescent Imaging for Inflammation Detection DOI Open Access

Cong Shao,

Xiaoxuan Wang,

Jingying Dai

et al.

Luminescence, Journal Year: 2025, Volume and Issue: 40(1)

Published: Jan. 1, 2025

ABSTRACT Hypochlorous acid (HClO) is released by immune cells in the system, and it helps body fight off infections inflammation killing bacteria, viruses, other pathogens. However, tissue damage or apoptosis may also be induced excess HClO. On this basis, we designed probe TPE‐NS choosing tetraphenylethylene (TPE) as luminescent unit dimethylthiocarbamoyl chloride recognition site. By Gaussian's transition state calculations, HClO will cut photoinduced electron transfer (PET) effect of hydrolysis reaction, thus emitting strong fluorescence. has rapid excellent specificity for HClO, limit detection 7.27 μM. Finally, was successfully used visualization endogenous exogenous cell experiments.

Language: Английский

Citations

0
Polarity, pH and HClO triple-response fluorescent probe and its application in inflammation models DOI

Ying Liu,

Weiling Yan,

Jingyu Li

et al.

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 126953 - 126953

Published: Jan. 1, 2025

Language: Английский

Citations

0
Development and application of a Phenothiazine-Based fluorescent probe for distinguishing hydrogen sulfide and hypochlorite in oxidative stress DOI
Jiaxue Yang,

San Tu,

Tingting Feng

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113160 - 113160

Published: Feb. 1, 2025

Language: Английский

Citations

0
Development of a Novel Dual-Emission Probe for Accurate Detection and Imaging of HClO in Environmental and Biological Systems DOI
Qi Li, Pengfei Qi, Luan Wang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138439 - 138439

Published: May 1, 2025

Language: Английский

Citations

0
A novel hepatocyte-targeting fluorescent probe of rhodamine analogues to detect hypochlorite in lysosomes: Design, synthesis and evaluation DOI

Xiangqing Qin,

Jiale Mei,

Yingjie Wang

et al.

Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2024, Volume and Issue: 453, P. 115597 - 115597

Published: March 18, 2024

Language: Английский

Citations

3
Large stokes shift and near-infrared fluorescent probe for bioimaging and evaluating the HClO in an rheumatoid arthritis mouse model DOI
Zhengmin Yang, Q. J. Jiang, Tiantian Zhong

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 319, P. 124547 - 124547

Published: May 27, 2024

Language: Английский

Citations

3
Win-win integration: A mitochondria targeted AIE photosensitizer for hypochlorite detection and type I & type II photodynamic therapy DOI

Jiahao Ni,

L.H. Yu, Yixuan Wang

et al.

Analytica Chimica Acta, Journal Year: 2024, Volume and Issue: 1320, P. 343035 - 343035

Published: July 28, 2024

Language: Английский

Citations

3
De Novo Construction of pKa‐Tunable Xanthene Molecules for pH Sensitive Fluorescence Navigation DOI Open Access
Lina Zhang, Shan‐Yong Chen, Lei Shi

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 29, 2024

Abstract pH is spatiotemporal variable dynamically in physiological and pathological processes, the tiny changes can result completely different processes. However, major drawbacks of conventional pH‐activatable probes are their large acid‐base transition width challenge to adjust pKa suitable for various application. In response these issues, a novel approach proposed realize sensitive general strategy construct multicolor pKa‐tunable xanthene‐based platform. probes, narrowest range just 1 units, achieved by introducing electron‐rich pyridine as ingenious proton catcher. Especially, Si‐4Py owns near‐infrared (NIR) signal 5.56, which successfully used rapid high‐contrast imaging distal metastatic tumors. This has significant implications guiding surgeons removal tumors ultimately improve patient outcomes. Additional, sustainably innovative this work serve effective reference probe development.

Language: Английский

Citations

3
High-Throughput Screening of Antioxidant Drug Candidates from Natural Antioxidants with a “Zero” Intrinsic Fluorescence Peroxynitrite Sensing Precursor DOI
Hong Zhang, Guannan Zhu,

Fei‐Fan Xiang

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 21, 2024

The fluorescence high-throughput screening method is of importance for new antioxidant drug candidate discovery the treatment serious hepatorenal syndrome, which displayed an obvious upregulated peroxynitrite level. However, most current ONOO

Language: Английский

Citations

1