Carmiseconapine A as a Promising Antidepressant Candidate: An Adenosine 5′-Monophosphate-Activated Protein Kinase Agonist with an Unprecedented Chemical Skeleton

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

A novel rearranged C20-diterpenoid alkaloid, carmiseconapline (1), featuring a unique 10,20:11,12-di-seco-napelline skeleton with fused 5/6/5/6/7 pentacyclic ring system, was isolated from Aconitum carmichaelii Debeaux. Compound 1 exhibited remarkable antidepressive activity, being twice as potent fluoxetine (10 mg/kg) at 0.06 mg/kg in mice. Further mechanism studies showed that effectively activated adenosine 5′-monophosphate-activated protein kinase (AMPK), protected HT22 cells mitochondrial dysfunction, and inhibited apoptosis. These findings suggested potential AMPK activator for antidepressant development.

Language: Английский

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Hot off the Press

Natural Product Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A personal selection of 32 recent papers is presented covering various aspects current developments in bioorganic chemistry and novel natural products such as melichuniione from Melicope chunii.

Language: Английский

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Anti-neuroinflammatory naphthol dimers from the marine-derived fungus Penicillium sp. HQ1-23

Phytochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 114534 - 114534

Published: May 1, 2025

Language: Английский

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Talarergosteroids A–C: Three Unusual Steroid-Polyketone Conjugates with Antifungal Activity from a Kandelia Obovata Derived Fungus Talaromyces sp

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Three previously undescribed steroid-polyketone conjugates, talarergosteroids A-C (

Language: Английский

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