Catalyst‐ and Solvent‐Free Upcycling of Poly(Ethylene Terephthalate) Waste to Biodegradable Plastics

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(46)

Published: Aug. 4, 2024

Poly(ethylene terephthalate) (PET) is an important polymer with annual output second only to polyethylene. Due its low biodegradability, a large amount of PET recycled for sustainable development. However, current strategies recycling are limited by added value or small product scale. It urgent make breakthrough on the principle macromolecular reaction and efficiently prepare products high wide applications. Here, catalyst- solvent-free synthesis biodegradable plastics reported through novel carboxyl-ester transesterification between waste bio-based hydrogenated dimer acid (HDA), which can directly substitute some terephthalic (TPA) units in chain HDA unit. This be facilely carried out equipment polyester industry without any additional catalyst solvent, thus enabling low-cost large-scale production. Furthermore, semi-bio-based copolyester shows excellent mechanical properties, regulable flexibility good expected poly(butylene adipate-co-terephthalate) (PBAT) plastic as value-added materials. work provides environmental-friendly economic strategy upcycling waste.

Language: Английский

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Zinc–gallic acid–polylysine nanocomplexes with enhanced bactericidal activity for the treatment of bacterial keratitis

e-Polymers, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 1, 2025

Abstract Bacterial keratitis is a common infectious eye disease. Conventional antibiotic drops are becoming less effective due to resistance. Herein, we design an innovative transition metal ion-based nano-delivery system for the treatment of bacterial keratitis. Zinc (Zn 2+ )–gallic acid–poly- l -lysine nanocomplex (ZGNC) designed by coordination interaction. ZGNC stable in physiological environment and can be dissociated acidic infected microenvironment. The positively charged effectively adhered onto cells subsequently realizes situ release Zn , leading much better bactericidal effect than free . Importantly, maintains excellent activity protein-rich environment, while completely invalid eradicate bacteria environment. vivo ability further confirmed murine model. This research provides promising method treat system.

Language: Английский

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Side-Chain Engineering of NIR-II-Emissive Aggregation-Induced Emission Luminogens to Boost Photodynamic and Photothermal Antimicrobial Therapy

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

The development of antibiotic resistance has made multidrug-resistant bacterial and fungal infections one the most serious health problems worldwide. Photothermal therapy (PTT) photodynamic (PDT) have received increasing attention in antimicrobial fields due to their precision treatment less susceptibility inducing resistance. In particular, developing second near-infrared (NIR-II, 1000-1700 nm)-emissive semiconducting polymers for phototheranostics is highly desirable but remains challenging lack rational molecular design guidelines. Herein, a precise side-chain engineering strategy based on donor-acceptor (D-A)-type semiconductor developed phototherapy. By subtle regulation flexibility, series NIR-II-emissive polymer aggregation-induced-emission (AIE) luminogens (AIEgens) are constructed. optimal PIDT(He)TBT bearing flexible side chains shows physicochemical properties, including highest mass extinction coefficient, best AIE property, red-shifted absorption/emission spectra, photothermal effects. then encapsulated into nanoparticles endow them with water solubility, excellent photostability, enhanced type-I performance terms fluorescence-guided PDT PTT been demonstrated both vitro vivo. This work brings useful insights designing AIEgens efficient phototheranostics.

Language: Английский

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Simultaneous inhibition of heat shock proteins and autophagy enhances radiofrequency ablation of hepatocellular carcinoma

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(23), P. 6082 - 6098

Published: Jan. 1, 2024

Radiofrequency ablation (RFA) is a commonly used minimally invasive treatment for hepatocellular carcinoma (HCC). However, incomplete radiofrequency (iRFA) promotes tumor progression and metastasis. There an urgent need to develop innovative strategies enhance the efficacy of iRFA. The upregulation heat shock proteins (HSPs) activation protective autophagy in cells upon exposure sublethal thermotolerance, thereby promoting cell survival. Here, 3-methyladenine (3-MA) lonidamine (LND) co-encapsulated liposomes (Lip@LND/3-MA) are designed iRFA by simultaneous inhibition glycolysis autophagy. On one hand, LND inhibits hexokinase, key enzyme glycolysis, thus reduces ATP production consequently suppresses expression HSPs. other 3-MA, as inhibitor, can inhibit after Lip@LND/3-MA confirmed suppress HSPs reduce level during RFA. Therefore, thermotolerance significantly weakened, leading remarkably enhanced therapeutic It believed that promising strategy clinical practice

Language: Английский

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Chitosan Hydrogels Loaded with pH-responsive Nanozymes for Precision Treatment of Wound Infection

Precision medicine and engineering., Journal Year: 2024, Volume and Issue: unknown, P. 100014 - 100014

Published: Nov. 1, 2024

Language: Английский

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Advancing H-Bonding Organocatalysis for Ring-Opening Polymerization: Intramolecular Activation of Initiator/Chain End

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(37), P. 25852 - 25859

Published: Sept. 3, 2024

Organocatalytic ring-opening polymerization (ROP) of lactones is a green method for accessing renewable and biodegradable polyesters. Developing new organocatalysts with high activity controllability major challenging research topic in this field. Here, we report series to achieve fast controlled ROP lactones. These catalysts incorporate (thio)urea alkoxide one molecule act as initiators the ROP. Such enable an effective intramolecular activation initiator/chain end, revealed by computational studies, resulting higher fewer loads than existing (thio)urea/alkoxide binary systems. exhibit ultrahigh comparable metal complexes, i.e., turnover number up 900 frequency 4860 min

Language: Английский

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Constructing Multifunctional Composite Single Crystals via Polymer Gel Incorporation

Polymers, Journal Year: 2024, Volume and Issue: 16(16), P. 2379 - 2379

Published: Aug. 22, 2024

The non-uniformity of a single crystal can sometimes be found in biominerals, where surrounding biomacromolecules are incorporated into the growing crystals. This unique composite structure, combining heterogeneity and long-range ordering, enables functionalization Polymer gel media often used to prepare crystals, which crystals incorporate networks form bi-continuous interpenetrating structure without any disruption crystallinity. Moreover, dyes many kinds nanoparticles occluded under guidance incorporation. On this basis, bio-inspired method has been applied morphology control, dyeing, mechanical reinforcement, organic bulk heterojunction-based optoelectronics. In paper, incorporation mechanisms, multiple functions gel-incorporated reviewed.

Language: Английский

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