Chinese Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: 22(12), P. 1065 - 1066
Published: Dec. 1, 2024
Language: Английский
Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110804 - 110804
Published: Jan. 1, 2025
Language: Английский
Citations
0
Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110907 - 110907
Published: Feb. 1, 2025
Language: Английский
Citations
0
Nanoscale, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Self-assembly prodrugs usually consist of drug modules, activation and assembly modules. The selection suitable modules to construct prodrug nanoassemblies with self-assembly stability "intelligent" is a challenge. As common module, oleic acid can provide driving force steric hindrance for self-assembly. However, the unsaturated double bond readily oxidized it affects its chemical stability. Herein, two docetaxel (DTX) were designed using disulfide bonds as different fatty acids (isostearic acid) respectively. Compared acid, isostearic had higher Simultaneously, terminal propyl structure compensated without bond. Overall, this structural deformation improved ability nanoassemblies, thus balancing effectiveness safety prodrugs. Our findings reveal importance guidance rational design nanoassemblies.
Language: Английский
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Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: March 6, 2025
Synthetic biology and nanotechnology fusion represent a transformative approach promoting fundamental clinical biomedical science development. In SynBioNanoDesign, biological systems are reimagined as dynamic programmable materials to yield engineered nanomaterials with emerging specific functionalities. This review elucidates comprehensive examination of synthetic biology's pivotal role in advancing for targeted drug delivery systems. It begins exploring the synergy between nanotechnology, then highlights current landscape applications. Subsequently, discusses design novel informed by principles, focusing on expounding tools potential developing advanced nanomaterials. Afterward, research advances innovative through were systematically summarized, emphasizing integration genetic circuitry program nanomaterial responses. Furthermore, challenges, weaknesses opportunities, prospective directions, ethical societal implications SynBioNanoDesign elucidated. Finally, summarizes impact that may have drug-delivery technologies future.
Language: Английский
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Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111222 - 111222
Published: April 1, 2025
Language: Английский
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Antibodies, Journal Year: 2024, Volume and Issue: 13(4), P. 90 - 90
Published: Nov. 11, 2024
This review briefly traces the historical development of antibody research and related technologies. The path from early perceptions immunity to emergence modern immunotherapy has been marked by pivotal discoveries technological advances. Early insights into led vaccination serotherapy. elucidation structure function paved way for monoclonal technology its application in diagnosis therapy. Breakthroughs genetic engineering have enabled production humanized antibodies advances Fc engineering, thereby increasing therapeutic efficacy. discovery immune checkpoints cytokines revolutionized treatment cancer autoimmune diseases. field continues evolve rapidly with advent antibody-drug conjugates, bispecific antibodies, CAR T-cell therapies. As we face global health challenges, remains at forefront medical innovation offers promising solutions future.
Language: Английский
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Chinese Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: 22(12), P. 1065 - 1066
Published: Dec. 1, 2024
Language: Английский
Citations
0