The Warburg Effect: How Does it Benefit Cancer Cells?

Trends in Biochemical Sciences, Journal Year: 2016, Volume and Issue: 41(3), P. 211 - 218

Published: Jan. 5, 2016

Language: Английский

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Fundamentals of cancer metabolism

Science Advances, Journal Year: 2016, Volume and Issue: 2(5)

Published: May 6, 2016

Researchers provide a conceptual framework to understand current knowledge of the fundamentals cancer metabolism.

Language: Английский

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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Nature, Journal Year: 2013, Volume and Issue: 496(7443), P. 101 - 105

Published: March 26, 2013

Language: Английский

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Serine, glycine and one-carbon units: cancer metabolism in full circle

Nature reviews. Cancer, Journal Year: 2013, Volume and Issue: 13(8), P. 572 - 583

Published: July 4, 2013

Language: Английский

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Beyond oxidative stress: an immunologist's guide to reactive oxygen species

Nature reviews. Immunology, Journal Year: 2013, Volume and Issue: 13(5), P. 349 - 361

Published: April 25, 2013

Language: Английский

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Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications

Chemical Reviews, Journal Year: 2017, Volume and Issue: 117(15), P. 10043 - 10120

Published: June 27, 2017

Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases. Currently, effective way to deliver drugs specifically mitochondria is by covalent linking a lipophilic cation such an alkyltriphenylphosphonium moiety pharmacophore interest. Other delocalized cations, rhodamine, natural synthetic mitochondria-targeting peptides, nanoparticle vehicles, have also been used mitochondrial delivery small molecules. Depending on approach used, cell membrane potentials, more than 1000-fold higher concentration can be achieved. Mitochondrial targeting has developed study physiology dysfunction interaction between other subcellular organelles treatment variety diseases neurodegeneration cancer. In this Review, we discuss efforts target small-molecule compounds probing function, diagnostic tools potential therapeutics. We describe physicochemical basis accumulation chemistry strategies mitochondria, probes, sensors, examples bioactive compounds. Finally, review published attempts apply mitochondria-targeted agents cancer neurodegenerative

Language: Английский

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Unravelling mechanisms of p53-mediated tumour suppression

Nature reviews. Cancer, Journal Year: 2014, Volume and Issue: 14(5), P. 359 - 370

Published: April 17, 2014

Language: Английский

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Targeting mitochondria metabolism for cancer therapy

Nature Chemical Biology, Journal Year: 2014, Volume and Issue: 11(1), P. 9 - 15

Published: Dec. 17, 2014

Language: Английский

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Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

Cell, Journal Year: 2015, Volume and Issue: 162(6), P. 1217 - 1228

Published: Aug. 27, 2015

Language: Английский

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Fueling Immunity: Insights into Metabolism and Lymphocyte Function

Science, Journal Year: 2013, Volume and Issue: 342(6155)

Published: Oct. 10, 2013

Lymphocytes face major metabolic challenges upon activation. They must meet the bioenergetic and biosynthetic demands of increased cell proliferation also adapt to changing environmental conditions, in which nutrients oxygen may be limiting. An emerging theme immunology is that reprogramming lymphocyte activation are intricately linked. However, why T cells adopt specific programs impact these have on function and, ultimately, immunological outcome remain unclear. Research tumor metabolism has provided valuable insight into pathways important for influence metabolites themselves signal transduction epigenetic programming. In this Review, we highlight concepts regarding proliferating discuss their potential fate function.

Language: Английский

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