Chemosensors based on quinazoline moieties

Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112638 - 112638

Published: Jan. 1, 2025

Language: Английский

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Recent progress in chemosensors based on pyrazole derivatives

RSC Advances, Journal Year: 2020, Volume and Issue: 10(33), P. 19693 - 19712

Published: Jan. 1, 2020

Colorimetric and fluorescent probes based on small organic molecules have become important tools in modern biology because they provide dynamic information concerning the localization quantity of ions interest without need for genetic engineering sample. In past five years, these attracted great attention their biological, environmental industrial significance combined with simplicity high sensitivity absorption fluorescence techniques. Moreover, pyrazole derivatives display a number remarkable photophysical properties wide synthetic versatility superior to those other broadly used scaffolds. This review provides an overview recent (2016-2020) findings chemosensors containing (pyrazoles, pyrazolines fused pyrazoles). The discussion focuses design physicochemical order realize full potential practical applications biological monitoring (sensing metal ions, anions, explosives, biomolecules). We also present our conclusions outlook future.

Language: Английский

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Small-molecule fluorescent probes for specific detection and imaging of chemical species inside lysosomes

Chemical Communications, Journal Year: 2019, Volume and Issue: 55(47), P. 6629 - 6671

Published: Jan. 1, 2019

This feature article comprehensively summarizes the development of small-molecule fluorescent probes for specific detection and imaging chemical species inside lysosomes.

Language: Английский

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Fast and selective detection of mercury ions in environmental water by paper-based fluorescent sensor using boronic acid functionalized MoS2 quantum dots

Journal of Hazardous Materials, Journal Year: 2019, Volume and Issue: 381, P. 120969 - 120969

Published: Aug. 5, 2019

Language: Английский

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Activatable Small‐Molecule Photoacoustic Probes that Cross the Blood–Brain Barrier for Visualization of Copper(II) in Mice with Alzheimer's Disease

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 58(36), P. 12415 - 12419

Published: July 16, 2019

Abstract Copper enrichment in the brain is highly related to Alzheimer's disease (AD) pathogenesis, but vivo tracing of Cu 2+ by imaging techniques still a great challenge. In this work, we developed series activatable photoacoustic (PA) probes with low molecular weights (less than 438 Da), RPS1 – RPS4 , which can specifically chelate form radicals turn‐on PA signals near‐infrared (NIR) region. Introducing electron‐donating group N ‐dimethylaniline into probe was found significantly enhance radical stability and intensity. The best series, showed fast response (within seconds) high selectivity detection limit 90.9 n m . Owing weight amphiphilic structure, could effectively cross blood–brain barrier (BBB) thus allowed us, for first time, visualize via brains AD mice.

Language: Английский

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Novel thiophene-based colorimetric and fluorescent turn-on sensor for highly sensitive and selective simultaneous detection of Al3+ and Zn2+ in water and food samples and its application in bioimaging

Analytica Chimica Acta, Journal Year: 2018, Volume and Issue: 1049, P. 196 - 212

Published: Oct. 23, 2018

Language: Английский

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Anthracene- and pyrene-bearing imidazoles as turn-on fluorescent chemosensor for aluminum ion in living cells

Dyes and Pigments, Journal Year: 2018, Volume and Issue: 163, P. 204 - 212

Published: Dec. 1, 2018

Language: Английский

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Dual chemosensors for metal ions: A comprehensive review

TrAC Trends in Analytical Chemistry, Journal Year: 2021, Volume and Issue: 138, P. 116204 - 116204

Published: Jan. 30, 2021

Language: Английский

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Rhodamine-Based Dual Chemosensor for Al³⁺ and Zn²⁺ Ions with Distinctly Separated Excitation and Emission Wavelengths

ACS Omega, Journal Year: 2019, Volume and Issue: 4(4), P. 6864 - 6875

Published: April 16, 2019

A rhodamine-based compound, 2-(2-((3-(tert-butyl)-2-hydroxybenzylidene)amino)ethyl)-3′-6′-bis(ethylamino)-2′,7′-dimethylspiro[indoline-1,9′-xanthen]-3-one, (HL-t-Bu), is reported here as a dual chemosensor for Zn2+ and Al3+ ions. This compound has been synthesized under mild conditions with high yield characterized by elemental analysis different standard spectroscopic methods. Its structure confirmed single-crystal X-ray diffraction analysis. It acts fluorescent sensor in 10 mM HEPES buffer the methanol/water mixture (9:1, pH = 7.4) well-separated excitation emission wavelengths. The fluorescence intensity at 457 nm of HL-t-Bu increases ∼7 folds presence 1 equiv when it excited 370 nm. With 500 nm, probe 550 massively (∼650 times) Al3+. No other metal any significant effect on enhancement detection process either quantum enhances significantly Rhodamine derivatives are generally colorless nonfluorescent spirolactam ring closed, they pink color highly exists ring-open form. In Al3+, fluorescent, indicating that this ion able to open probe. However, not ring, but coordinated through phenolic oxygen imine nitrogen (salicylaldehyde unit) Schiff base restricting PET (photoinduced electron transfer) imposing CHEF (chelation-enhanced fluorescence) enhance 1H NMR, FT-IR, analysis, pH-dependent studies support these mechanisms. Limit values nanomolar range both ions, confirming very sensitivity used cell imaging

Language: Английский

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Transition‐Metal Complexes of Bidentate Schiff‐Base Ligands: In Vitro and In Silico Evaluation as Non‐Classical Carbonic Anhydrase and Potential Acetylcholinesterase Inhibitors

ChemistrySelect, Journal Year: 2021, Volume and Issue: 6(29), P. 7278 - 7284

Published: Aug. 2, 2021

Abstract Schiff bases display superior features for many areas, such as significant intermediates in industrial biological, pharmacological, catalytic and optical properties, organic synthesis, coordination chemistry. The pre‐synthesized two base ligands ( HL 1 2 ) their bidentate metal complexes Co(L , Cu L Ni were tested inhibition activities on acetylcholinesterase (AChE) human carbonic anhydrase h CA I II) isoforms. transition of displayed the potent effect with K constants ranging from 16.39±0.15 to 88.63±0.27 nM 9.32±0.13 33.66±0.57 isoenzymes AChE, respectively. compound AChE II had highest inhibitory effect. Besides, molecular docking analyses most active performed understand binding interactions enzymes’ sites. According both vitro silico analysis results, all compounds potential inhibitors I, isoenzymes.

Language: Английский

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