Advanced Functional Materials,
Journal Year:
2022,
Volume and Issue:
33(1)
Published: Oct. 31, 2022
Abstract
Organic
light‐emitting
materials
in
the
near‐infrared
(NIR)
region
are
important
to
realize
next‐generation
lightweight
and
wearable
applications
bioimaging,
photodynamic
therapy,
telecommunications.
Inorganic
organometallic
expensive
toxic;
thus,
development
of
purely
organic
is
essential.
However,
highly
efficient
NIR
made
still
its
infancy.
Therefore,
this
review
outlines
molecular
design
strategies
for
developing
small‐molecule
with
high
emission
efficiency
that
can
overcome
energy‐gap
law
be
applied
devices.
After
briefly
reviewing
basic
knowledge
required
molecules,
representative
high‐efficiency
molecules
reported
over
past
5
years
classified
according
their
core
moieties,
design,
physical
properties,
luminescence
characteristics
analyzed.
Further,
perspective
outlook
regarding
provided.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
49(21), P. 7533 - 7567
Published: Jan. 1, 2020
This
review
highlights
the
empirical
design
guidelines
and
photophysical
property
manipulation
of
Aza-BODIPY
dyes
latest
advances
in
their
bioapplications.
Angewandte Chemie International Edition,
Journal Year:
2021,
Volume and Issue:
61(14)
Published: Dec. 7, 2021
Abstract
Optical
imaging,
especially
fluorescence
and
photoacoustic
is
a
non‐invasive
imaging
approach
with
high
spatial
temporal
resolution
sensitivity,
compared
to
positron
emission
tomography
(PET)
or
magnetic
resonance
(MRI).
Due
the
merits
of
using
second
near‐infrared
(NIR‐II)
window,
like
deeper
penetration
depth,
signal‐to‐noise
ratio,
resolution,
low
tissue
damage,
researchers
have
devoted
great
effort
developing
contrast
agents
NIR‐II
absorption
emission.
In
this
Review,
we
summarize
recently
developed
organic
luminescent
materials,
ranging
from
small
molecules
conjugated
polymers.
Then,
systematically
introduce
engineering
strategies
describe
performance
classified
by
skeleton
cores.
Finally,
elucidate
challenges
prospects
these
dyes
for
potential
clinical
applications.
We
expect
our
summary
can
inspire
expand
spectrum
diverse
bioapplications.
Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
31(26)
Published: March 23, 2021
Abstract
The
facile
preparation,
modular
design,
and
multi‐responsiveness
are
extremely
critical
for
developing
pervasive
nanoplatforms
to
meet
heterogeneous
applications.
Here,
cationic
nanogels
(NGs)
modularly
engineered
with
tunable
responsiveness,
versatility,
biodegradation.
Cationic
PVCL‐based
NGs
core/shell
structure
fabricated
by
one‐step
synthesis.
formed
PVCL‐NH
2
exhibit
uniform
size,
thermal/pH
dual‐responsive
behaviors,
redox‐triggered
degradation.
Moreover,
the
can
be
employed
modify
or/and
load
various
functional
agents
construct
multipurpose
in
a
manner.
Notably,
novel
hybrid
copper
sulfide
(CuS)
NPs
loaded
shell
is
prepared,
which
leads
higher
photothermal
conversion
efficiency
(31.1%)
than
other
CuS
randomly
reported.
By
personalized
tailoring,
these
functionalized
display
fluorescent
property,
r
1
relaxivity,
strong
near‐infrared
(NIR)
absorption,
good
biocompatibility,
targeting
specificity.
superior
effect
of
(CuS@NGs‐LA)
presented
under
NIR
II
over
I.
Importantly,
encapsulated
doxorubicin
(CuS@NGs‐LA/DOX)
show
endogenous
pH/redox
exogenous
multi‐triggered
drug
release
efficient
photothermal‐chemotherapy,
completely
eliminate
advanced
tumors
effectively
inhibit
recurrence.
Overall,
based
on
intelligent
biodegradation
developed
strategy
precision
medicine
The Innovation,
Journal Year:
2021,
Volume and Issue:
2(1), P. 100082 - 100082
Published: Jan. 19, 2021
Phototheranostics
integrates
deep-tissue
imaging
with
phototherapy
(containing
photothermal
therapy
and
photodynamic
therapy),
holding
great
promise
in
early
diagnosis
precision
treatment
of
cancers.
Recently,
second
near-infrared
(NIR-II)
fluorescence
exhibits
the
merits
high
accuracy
specificity,
as
well
real-time
detection.
Among
NIR-II
fluorophores,
organic
small
molecular
fluorophores
have
shown
superior
properties
biocompatibility,
variable
structure,
tunable
emission
wavelength
than
inorganic
materials.
What's
more,
some
also
display
excellent
cytotoxicity
when
illuminated
NIR
laser.
This
review
summarizes
progress
different
central
cores
for
cancer
phototheranostics
past
few
years,
focusing
on
structures
phototheranostic
performances.
Furthermore,
challenges
prospects
future
development
toward
clinical
translation
are
discussed.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: April 14, 2022
Although
Ru(II)-based
agents
are
expected
to
be
promising
candidates
for
substituting
Pt-drug,
their
in
vivo
biomedical
applications
still
limited
by
the
short
excitation/emission
wavelengths
and
unsatisfactory
therapeutic
efficiency.
Herein,
we
rationally
design
a
Ru(II)
metallacycle
with
excitation
at
808
nm
emission
over
1000
nm,
namely
Ru1085,
which
holds
deep
optical
penetration
(up
6
mm)
enhanced
chemo-phototherapy
activity.
In
vitro
studies
indicate
that
Ru1085
exhibits
prominent
cell
uptake
desirable
anticancer
capability
against
various
cancer
lines,
especially
cisplatin-resistant
A549
cells.
Further
reveal
induces
mitochondria-mediated
apoptosis
along
S
G2/M
phase
cycle
arrest.
Finally,
shows
precise
NIR-II
fluorescence
imaging
guided
long-term
monitored
tumor
minimal
side
effects.
We
envision
of
long-wavelength
emissive
will
offer
emerging
opportunities
metal-based
applications.
Proceedings of the National Academy of Sciences,
Journal Year:
2022,
Volume and Issue:
119(32)
Published: Aug. 1, 2022
Ruthenium
(Ru)
complexes
are
developed
as
latent
emissive
photosensitizers
for
cancer
and
pathogen
photodiagnosis
therapy.
Nevertheless,
most
existing
Ru
limited
in
terms
of
short
excitation
emission
wavelengths.
Herein,
we
present
an
Ru(II)
metallacycle
(herein
referred
to
1)
that
is
excited
by
808-nm
laser
emits
at
a
wavelength
∼1,000
nm
via
coordination-driven
self-assembly.
Metallacycle
1
exhibits
good
optical
penetration
(∼7
mm)
satisfactory
reactive
oxygen
species
production
properties.
Furthermore,
shows
broad-spectrum
antibacterial
activity
(including
against
drug-resistant
Escherichia
coli)
well
low
cytotoxicity
normal
mammalian
cells.
In
vivo
studies
reveal
employed
precise,
second
near-infrared
biomedical
window
fluorescent
imaging-guided,
photo-triggered
treatments
Staphylococcus
aureus-infected
mice
models,
with
negligible
side
effects.
This
work
thus
broads
the
applications
supramolecular
through
strategy
lengthening
their
