Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 26, 2024
Abstract
Mild
photothermal
therapy
(MPTT)
has
emerged
as
a
promising
therapeutic
modality
for
attenuating
thermal
damage
to
the
normal
tissues
surrounding
tumors,
while
heat‐induced
upregulation
of
heat
shock
proteins
(HSPs)
greatly
compromises
curative
efficacy
MPTT
by
increasing
cellular
thermo‐tolerance.
Ferroptosis
been
identified
suppress
overexpression
HSPs
accumulation
lipid
peroxides
and
reactive
oxygen
species
(ROS),
but
is
restricted
overexpressed
glutathione
(GSH)
in
tumor
microenvironment
undesirable
ROS
generation
efficiency.
Herein,
synergistic
strategy
based
on
mutual
enhancement
ferroptosis
proposed
cleaving
recover
cell
sensitivity.
A
facile
method
fabricating
series
Fe‐based
metal‐quinone
networks
(MQNs)
coordinated
assembly
representative
FTP
MQNs
possess
high
conversion
efficiency
(69.3
%).
Upon
808
nm
laser
irradiation,
not
only
trigger
effective
induce
apoptosis
more
significantly,
potentiate
Fenton
reaction
marked
GSH
consumption
boost
ferroptosis,
reinforced
effect
turn
can
alleviate
resistance
declining
HSP70
defense
reducing
ATP
levels.
This
study
provides
valuable
rationale
constructing
large
library
achieving
ferroptosis.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(30)
Published: May 1, 2024
Abstract
The
in
vivo
fate
of
chemotherapeutic
drugs
plays
a
vital
role
understanding
the
therapeutic
outcome,
side
effects,
and
mechanism.
However,
lack
imaging
abilities
drugs,
tedious
labeling
processes,
premature
leakage
agents
result
loss
fidelity
between
signals.
Herein,
an
amphiphilic
polymer
is
created
by
copolymerization
near‐infrared‐II
(NIR‐II)
fluorophore
tracer
(T)
anticancer
Pt(IV)
prodrug
(D)
cisplatin
hand‐holding
manner
into
one
chain
for
first
time.
obtained
Polyplatin
DT
capable
delivering
fluorophores
concomitantly
at
precise
D/T
ratio,
thereby
resulting
tracking
platinum
even
readout
them
real‐time
via
NIR‐II
imaging.
can
self‐assemble
nanoparticles,
referred
to
as
Nanoplatin
.
Furthermore,
caspase‐3
cleavable
peptide
that
serves
apoptosis
reporter
attached
,
DTR
are
simultaneously
evaluating
efficacy.
Overall,
it
reported
here
design
theranostic
with
drug
tracers,
efficacy
reporters
work
concert
provide
insight
mechanism
action.
Nano Letters,
Journal Year:
2024,
Volume and Issue:
24(34), P. 10699 - 10709
Published: Aug. 14, 2024
The
insufficient
antioxidant
reserves
in
tumor
cells
play
a
critical
role
reactive
oxygen
species
(ROS)-mediated
therapeutics.
Metallothionein-2
(MT-2),
an
intracellular
cysteine-rich
protein
renowned
for
its
potent
properties,
is
intricately
involved
development
and
correlates
with
poor
prognosis.
Consequently,
MT-2
emerges
as
promising
target
therapy.
Herein,
we
present
the
of
copper-doped
carbon
dots
(Cu-CDs)
to
compromise
delicate
cells.
These
Cu-CDs
high
accumulation
prolonged
body
retention
can
effectively
suppress
growth
by
inducing
oxidative
stress.
Transcriptome
sequencing
unveils
significant
decrease
expression
within
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 20, 2024
Abstract
Cancer
is
recognized
as
one
of
the
major
causes
mortality,
however,
early‐stage
detection
can
increase
survival
chance
greatly.
It
that
folate
receptors
are
gradually
overexpressed
in
cellular
membrane
with
progress
cancer
from
stage
1
to
4.
Utilizing
fact,
herein,
developed
a
porous
silica
nanoparticle
system
C1
@SiO
2
–FA–NP;
A)
impregnated
thermodynamically
stable
Mn(II)
complex
(
)
molecules
within
core
nanoparticle,
and
B)
surface
functionalized
units.
exhibited
high
longitudinal
relaxivity
value
r
=
21.45
m
M
−1
s
substantially
increased
40.97
presence
0.67
concentration
BSA
under
physiological
condition.
The
vitro
fluorescent
images
after
conjugation
–FA–NP
FITC
(fluorescein
isothiocyanate)
buttressed
inclusion
exclusively
cancerous
HeLa
cells
than
healthy
HEK293
cells.
importance
surface‐bound
unit
further
established
by
comparing
absence
group.
Finally,
applicability
T
‐weighted
MRI
contrast
agent
for
diagnosis
C57BL/6
mice
infecting
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 26, 2024
Mild
photothermal
therapy
(MPTT)
has
emerged
as
a
promising
therapeutic
modality
for
attenuating
thermal
damage
to
the
normal
tissues
surrounding
tumors,
while
heat-induced
upregulation
of
heat
shock
proteins
(HSPs)
greatly
compromises
curative
efficacy
MPTT
by
increasing
cellular
thermo-tolerance.
Ferroptosis
been
identified
suppress
overexpression
HSPs
accumulation
lipid
peroxides
and
reactive
oxygen
species
(ROS),
but
is
restricted
overexpressed
glutathione
(GSH)
in
tumor
microenvironment
undesirable
ROS
generation
efficiency.
Herein,
synergistic
strategy
based
on
mutual
enhancement
ferroptosis
proposed
cleaving
recover
cell
sensitivity.
A
facile
method
fabricating
series
Fe-based
metal-quinone
networks
(MQNs)
coordinated
assembly
representative
FTP
MQNs
possess
high
conversion
efficiency
(69.3
%).
Upon
808
nm
laser
irradiation,
not
only
trigger
effective
induce
apoptosis
more
significantly,
potentiate
Fenton
reaction
marked
GSH
consumption
boost
ferroptosis,
reinforced
effect
turn
can
alleviate
resistance
declining
HSP70
defense
reducing
ATP
levels.
This
study
provides
valuable
rationale
constructing
large
library
achieving
ferroptosis.
Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
21(6), P. 905 - 920
Published: June 2, 2024
Introduction
This
review
discusses
novel
hybrid
assemblies
that
are
based
on
liposomal
formulations.
The
focus
is
the
constructs
formed
through
integration
of
liposomes/vesicles
with
other
nano-objects
such
as
nucleic
acid
nanostructures
and
metallic
nanoparticles.
aim
to
introduce
some
recent,
specific
examples
bridge
different
technologies
thus
may
form
a
new
platform
for
advanced
drug
delivery
applications.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
14(2)
Published: Nov. 19, 2024
Abstract
Magnetic
resonance
imaging
(MRI)
is
a
noninvasive
and
radiation‐free
technique
used
for
soft
tissue.
However,
there
are
some
limitations
of
the
MRI
modality,
such
as
low
sensitivity
poor
image
resolution.
Artificially
engineered
magnetic
nanoprobes
have
been
extensively
explored
versatile
platform
ultrasensitive
contrast
agents
due
to
their
unique
physiochemical
characteristics
tunable
properties.
In
this
review,
emphasis
on
recent
progress
in
with
different
structures
elements,
including
gadolinium‐,
iron‐,
manganese‐based
metal‐free
nanoprobes.
The
key
influencing
factors
advanced
engineering
strategies
modulating
relaxation
ratio
systematically
condensed.
Furthermore,
widespread
visualization
applications
real
time
monitoring
major
organs
accurate
disease
diagnosing,
cerebrovascular,
ischemia,
Alzheimer's
disease,
liver
fibrosis,
whole‐body
tumors,
inflammation,
well
multi‐mode
summarized.
Finally,
challenges
prospects
future
development
discussed,
promising
specifically
emphasized
improving
biocompatibility,
precisely
optimal
size,
AI‐driven
prediction
design,
multifunctional
self‐assembly
enhance
diagnostics.
This
review
will
provide
new
inspiration
artificial
nanotechnology‐based
molecular
probes
medical
diagnosis
therapy
MRI.
