Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 17, 2024
Introduction
Chiral
nanocarriers
enhance
therapeutic
efficacy
by
improving
in
vivo
stability
and
cellular
uptake.
Chemical
functionalization
reduces
cytotoxicity,
resulting
favorable
biocompatibility.
Nanoparticles
self-assemble
into
supraparticles,
enhancing
drug
delivery
through
improved
retention
loading.
Area
covered
This
review
covers
chiral
nanostructures
their
mechanisms,
applications
various
healthcare
applications.
Expert
Opinion
The
chirality
of
biomaterials
is
crucial
for
advancing
nanomedicine.
nanosystem
interacting
selectively
with
biological
molecules,
specificity
efficacy.
off-target
effects
improves
outcomes.
Research
has
focused
on
uptake
elimination
to
ensure
safety,
nanomaterials
also
show
promise
optical
sensing
gene
editing.
Their
biocompatibility
ability
supraparticles
may
make
them
ideal
systems.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(21)
Published: Feb. 7, 2024
Single-atom
nanozymes
(SAzymes)
showcase
not
only
uniformly
dispersed
active
sites
but
also
meticulously
engineered
coordination
structures.
These
intricate
architectures
bestow
upon
them
an
exceptional
catalytic
prowess,
thereby
captivating
numerous
minds
and
heralding
a
new
era
of
possibilities
in
the
biomedical
landscape.
Tuning
microstructure
SAzymes
on
atomic
scale
is
key
factor
designing
targeted
with
desirable
functions.
This
review
first
discusses
summarizes
three
strategies
for
their
impact
reactivity
biocatalysis.
The
effects
choices
carrier,
different
synthesis
methods,
modulation
first/second
shell,
type
number
metal
centers
enzyme-like
activity
are
unraveled.
Next,
attempt
made
to
summarize
biological
applications
tumor
therapy,
biosensing,
antimicrobial,
anti-inflammatory,
other
from
mechanisms.
Finally,
how
designed
regulated
further
realization
diverse
reviewed
prospected.
It
envisaged
that
comprehensive
presented
within
this
exegesis
will
furnish
novel
perspectives
profound
revelations
regarding
SAzymes.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 9, 2025
Chiral
nanomaterials
are
widely
investigated
over
recent
decades
due
to
their
biocompatibility
and
unique
chiral
effects.
These
key
properties
have
significantly
promoted
the
rapid
development
of
in
bioengineering
medicine.
In
this
review,
basic
principles
constructing
along
with
latest
progress
research
comprehensively
summarized.
Then,
application
for
diagnosis
neurodegenerative
diseases
(NDDs)
is
systematically
described.
addition,
significant
potential
broad
prospects
treatment
NDDs
highlighted
from
several
aspects,
including
disaggregation
neurofibrils,
scavenging
reactive
oxygen
species,
regulation
microbial-gut-brain
axis,
elimination
senescent
cells,
promotion
directed
differentiation
neural
stem
cells.
Finally,
a
perspective
challenges
future
provided.
Angewandte Chemie,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 12, 2025
Abstract
Nanozymes
with
atomically
dispersed
metal
sites
(ADzymes),
especially
single‐atom
nanozymes,
have
attracted
widespread
attention
in
recent
years
due
to
their
unique
advantages
mimicking
the
active
of
natural
enzymes.
These
nanozymes
not
only
maximize
exposure
catalytic
but
also
possess
superior
activity
performance,
achieving
challenging
reactions.
position
ADzymes
as
highly
promising
candidates
field
sensing
and
biosensing.
This
review
summarizes
classification
properties
ADzymes,
systematically
highlighting
some
typical
regulation
strategies
involving
central
metal,
coordination
environment,
etc.,
achieve
catalytical
activity,
specificity,
multifunctionality.
Then,
we
present
advances
different
fields,
including
colorimetry,
fluorescence,
electrochemistry,
chemiluminescence,
photoelectrochemistry,
electrochemiluminescence.
Taking
advantage
resultant
show
great
potential
goal
sensitivity,
selectivity
accuracy
for
detection
various
targets.
Specifically,
underlying
mechanisms
terms
signal
amplification
were
discussed
detail.
Finally,
current
challenges
perspectives
on
development
advanced
are
discussed.
Angewandte Chemie International Edition,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 12, 2025
Abstract
Nanozymes
with
atomically
dispersed
metal
sites
(ADzymes),
especially
single‐atom
nanozymes,
have
attracted
widespread
attention
in
recent
years
due
to
their
unique
advantages
mimicking
the
active
of
natural
enzymes.
These
nanozymes
not
only
maximize
exposure
catalytic
but
also
possess
superior
activity
performance,
achieving
challenging
reactions.
position
ADzymes
as
highly
promising
candidates
field
sensing
and
biosensing.
This
review
summarizes
classification
properties
ADzymes,
systematically
highlighting
some
typical
regulation
strategies
involving
central
metal,
coordination
environment,
etc.,
achieve
catalytical
activity,
specificity,
multifunctionality.
Then,
we
present
advances
different
fields,
including
colorimetry,
fluorescence,
electrochemistry,
chemiluminescence,
photoelectrochemistry,
electrochemiluminescence.
Taking
advantage
resultant
show
great
potential
goal
sensitivity,
selectivity
accuracy
for
detection
various
targets.
Specifically,
underlying
mechanisms
terms
signal
amplification
were
discussed
detail.
Finally,
current
challenges
perspectives
on
development
advanced
are
discussed.
Langmuir,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 28, 2025
Understanding
the
crystal
facet
effect
in
chiral
enantiomer
recognition
plays
an
important
role
designing
and
fabricating
nanozymes
for
biosensing
biodetection
applications.
Herein,
we
design
ideal
platform
to
study
using
cubic
icosahedral
PdPt3
hollow
nanocages
(NCs)
as
peroxidase
mimics
via
surface
ligand
decoration
of
l/d-cysteine
(l/d-Cys).
The
two
NCs
have
same
structure
ligand,
particle
size,
wall
thickness,
area,
elemental
composition,
with
only
difference
exposed
facets,
i.e.,
{100}
NC-l/d-Cys
{111}
NC-l/d-Cys.
demonstrates
2.2-fold
higher
peroxidase-like
catalytic
activity
than
facet,
which
also
leads
better
performance
discerning
3,4-dihydroxy-l/d-phenylalanine.
Our
work
provides
concept
tuning
high
stereoselective
properties.
