Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 15, 2024
ABSTRACT
While
nanomedicine
research
shows
a
great
progress
in
the
treatment
of
cancer,
it
still
faces
challenges
tumor
recurrence
and
metastasis.
Numerous
studies
have
demonstrated
intricate
crosstalk
between
platelets
cells.
The
re‐education
by
cells
enables
these
to
provide
critical
assistance
for
proliferation,
recurrence,
Engineered
shown
promising
potential
tumors,
postoperative
Different
engineering
technologies
such
as
surface
modification,
gene
editing,
membrane
coating,
loading
into
hydrogels
can
produce
multifunctional
customized
engineered
platelets.
These
inherit
key
properties
platelets,
including
long
blood
circulation,
targeting,
thrombus
be
stimulated
generate
derivatized
particles.
In
this
review,
we
elucidate
role
complex
processes
tumorigenesis
progression
summarize
emerging
paradigm
therapy.
purpose
review
is
comprehensively
explore
value
toward
clinical
providing
valuable
reference
further
development
their
broader
applications
field
cancer
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(9), P. 2002 - 2002
Published: Sept. 3, 2024
Contemporary
nutraceutical
and
biomedical
sectors
are
witnessing
fast
progress
in
efficient
product
development
due
to
the
advancements
nanoscience
encapsulation
technology.
Nutraceuticals
generally
defined
as
food
substances,
or
a
section
thereof,
that
provide
us
with
health
benefits
such
disease
prevention
therapy.
Nutraceutical
compounds
well
supplements
natural
approach
for
attaining
therapeutic
outcomes
negligible
ideally
no
adverse
effects.
Nonetheless,
these
materials
susceptible
deterioration
exposure
heat,
oxygen,
moisture,
light,
unfavorable
pH
values.
Tocosomes,
bilayered
lyotropic
vesicles,
an
ideal
protocol
industries.
Biocompatibility,
high
entrapment
capacity,
storage
stability,
improved
bioavailability,
site
specific
delivery,
sustained-release
characteristics
among
advantages
of
this
nanocarrier.
Similar
liposomal
carriers
nanoliposomes,
tocosomes
able
encapsulate
hydrophilic
hydrophobic
separately
simultaneously,
offering
synergistic
bioactive
delivery.
This
manuscript
describes
different
aspects
tocosome
parallel
liposome
nanoliposome
technologies
pertaining
nanonutraceutical
applications.
Different
properties
nanocarriers,
their
physicochemical
characteristics,
preparation
approaches,
targeting
mechanisms,
applications
industries,
also
covered.
Current Issues in Molecular Biology,
Journal Year:
2025,
Volume and Issue:
47(3), P. 172 - 172
Published: March 4, 2025
Chemotherapy
for
cancer
frequently
uses
platinum-based
medications,
including
oxaliplatin,
carboplatin,
and
cisplatin;
however,
due
to
their
high
systemic
toxicity,
lack
of
selectivity,
drug
resistance,
other
side
effects,
medications
have
very
limited
clinical
application.
As
a
first-line
medication
in
antitumor
therapy,
oxaliplatin
must
be
administered
minimize
effects
while
achieving
anticancer
objectives.
A
new
CDC7
inhibitor
called
XL413
has
demonstrated
promising
therapeutic
variety
malignant
tumors
may
properties.
This
offers
fresh
viewpoint
on
how
lessen
resistance
and,
specifically,
increase
the
potency
already
prescribed
therapies.
In
this
paper,
current
developments
therapy
are
discussed,
along
with
many
mechanisms
oxaliplatin’s
treatment
challenges,
related
approaches.
We
conducted
more
research
that
arose
during
chemotherapy
searched
ways
it
order
enhance
its
chemotherapeutic
performance.
Ultimately,
we
studied
distinct
routes
relate
one
another.
Meanwhile,
XL413,
novel
inhibitor,
perspective
possibilities
developing
approaches
innovation
point.
The
search
terms
“Oxaliplatin,
treatment,”
etc.,
were
applied
X-MOL
PubMed
databases
review’s
literature
search.
Boolean
logic
was
then
employed
maximize
approach.
These
can
offer
thorough
data
cover
broad
range
biological
publications.
Excluded
publications
works
low
relevance,
duplicates,
or
those
insufficient
information.
mechanism
effect,
amelioration,
role
main
topics
140
ultimately
included
analysis.
Gels,
Journal Year:
2025,
Volume and Issue:
11(3), P. 218 - 218
Published: March 20, 2025
Diffuse
large
B-cell
lymphoma
(DLBCL),
accounting
for
31%
of
non-Hodgkin
lymphomas,
remains
recalcitrant
to
conventional
therapies
due
chemoresistance,
metastatic
progression,
and
immunosuppressive
microenvironments.
We
report
a
novel
injectable
Fe3O4@DMSA@Pt@PLGA-PEG-PLGA
hydrogel
system
integrating
magnetothermal
therapy
(MHT),
chemodynamic
(CDT),
immunomodulation.
Under
alternating
magnetic
fields
(AMF),
the
achieves
rapid
therapeutic
hyperthermia
(50
°C
within
7
min)
while
activating
pH/temperature-dual
responsive
peroxidase
(POD)
-like
activity
in
Fe3O4@DMSA@Pt
nanoparticles.
Catalytic
efficiency
under
tumor-mimetic
conditions
was
significantly
higher
than
Fe3O4@DMSA
controls,
generating
elevated
reactive
oxygen
species
(ROS).
Flow
cytometry
revealed
75.9%
apoptotic
cell
death
A20
cells
at
50
°C,
surpassing
CDT
alone
(24.5%).
Importantly,
this
dual
mechanism
induced
immunogenic
(ICD)
characterized
by
4.1-fold
CRT
externalization,
68%
HMGB1
nuclear
depletion,
40.74
nM
ATP
secretion.
This
triggered
robust
dendritic
maturation
(92%
CD86+/CD80+
DCs
comparable
LPS
controls)
T
activation
(16.9%
CD25+/CD69+
ratio,
130-fold
baseline).
Our
findings
validate
potential
magnetothermal-chemodynamic
synergy
DLBCL
treatment,
paving
way
innovative
multi-mechanism
strategies
against
with
clinical
translation
prospects.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(10), P. 2321 - 2321
Published: May 15, 2024
This
review
presents
an
overview
of
the
biological
applications
coordinative
compounds
based
on
unsaturated
carboxylates
accompanied
by
other
ligands,
usually
N-based
heterocyclic
species.
The
interest
in
these
arises
from
valuable
antimicrobial
and
antitumor
activities
evidenced
some
species,
as
well
their
ability
to
generate
metal-containing
polymers
suitable
for
various
medical
purposes.
Therefore,
we
describe
recently
discovered
aspects
related
synthesis,
structure,
activity
a
wide
range
carboxylate-containing
species
metal
ions,
originating
mostly
3d
series.
encountered
are
acrylate,
methacrylate,
fumarate,
maleate,
cinnamate,
ferulate,
coumarate,
itaconate.
Regarding
properties
investigated
compounds,
it
is
worth
mentioning
good
inhibit
development
resistant
strains
or
microbial
biofilms
inert
surfaces
or,
even
more,
exert
against
cells.
intercalate
into
DNA
strands
scavenge
ROS
also
addressed.
