Near infrared lipid droplet specific fluorescent probes based on phenothiazine derivatives for wash-free imaging and diagnosis of non-alcoholic fatty liver DOI
Yuqing Wang, Kun Yu, Jing Yang

et al.

Journal of Industrial and Engineering Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs DOI
Lizhen Xu, Qian Zhang, Xin Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 519, P. 216122 - 216122

Published: Aug. 6, 2024

Language: Английский

Citations

18
Near-infrared polarity fluorescent probe for wash-free imaging lipid droplets and the application in the diagnosis of non-alcoholic fatty liver tissue DOI
Zhiyu Wang,

Jie Wang,

Yi Deng

et al.

Microchemical Journal, Journal Year: 2024, Volume and Issue: 205, P. 111236 - 111236

Published: July 17, 2024

Language: Английский

Citations

5
Visualizing Endoplasmic Reticulum Stress and Autophagy in Alzheimer’s Model Cells by a Peroxynitrite-Responsive AIEgen Fluorescent Probe DOI

Lushan Huang,

Liyi Ma,

Qunyan Zhu

et al.

ACS Chemical Neuroscience, Journal Year: 2025, Volume and Issue: 16(2), P. 223 - 231

Published: Jan. 7, 2025

Endoplasmic reticulum (ER) stress and autophagy (ER-phagy) occurring in nerve cells are crucial physiological processes closely associated with Alzheimer's disease (AD). Visualizing the two is paramount to advance our understanding of AD pathologies. Among biomarkers identified, peroxynitrite (ONOO-) emerges as a key molecule initiation aggravation ER ER-phagy, highlighting its significance underlying mechanisms processes. In this work, we designed synthesized an innovative ONOO--responsive AIEgen-based fluorescent probe (DHQM) ability monitor ER-phagy model cells. DHQM demonstrated excellent aggregation-induced emission (AIE) properties, endowing it outstanding for washing-free intracellular imaging. Meanwhile, exhibited high sensitivity, remarkable selectivity ONOO-, exceptional ER-targeting ability. The was successfully applied fluorescence imaging ONOO- fluctuations assess status aluminum-induced Our findings revealed that ferroptosis, regulated cell death process, pivotal excessive production, which turn activated exacerbated stress. Furthermore, aluminum-stimulated observed utilizing DHQM, might be inhibiting ferroptosis mitigating aberrant Overall, study not only offers valuable insights into pathological at level but also opens new potential therapeutic avenues targeting these pathways.

Language: Английский

Citations

0
Light-up lipid droplets dynamic behaviors using rationally designed carbon dots DOI

Yachu Meng,

Jian‐Hua Guo, Hongmei Xu

et al.

Talanta, Journal Year: 2025, Volume and Issue: 287, P. 127625 - 127625

Published: Jan. 24, 2025

Language: Английский

Citations

0
Development of a Near-Infrared Probe for Enhancing Cancer Therapy by Mitigating Pyroptosis-Induced Inflammation DOI
Bin Li, Weikang Peng,

Zhihang Jin

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Pyroptosis, a specialized cell death mechanism crucial in cancer therapy, is distinct from apoptosis and primary necrosis. It linked to inflammation reactive oxygen species, particularly peroxynitrite (ONOO-), which implicated disease. Monitoring pyroptosis challenging due its connection with cellular polarity the tumor environment. In this research, we developed near-infrared probe, PBQI, highly sensitive responsive ONOO- fluctuations. PBQI targets mitochondria lipid droplets, enabling real-time tracking of pyroptosis-associated subcellular alterations. was found differentiate between normal cells during triggered by cisplatin metformin. To mitigate pyroptosis-induced inflammation, disulfiram used as an inhibitor, significantly alleviating excessive inflammation. This study highlights PBQI's utility studying interplay polarity, ONOO-, pyroptosis, contributes development more targeted therapies that optimize pyroptosis's antitumor benefits while minimizing inflammatory side effects.

Language: Английский

Citations

0
Exploring cellular dynamics: Engineered fluorescent carbon dots for organelle staining and cellular response analysis DOI
Binesh Unnikrishnan,

Anisha Anand,

Chin‐Jung Lin

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 534, P. 216552 - 216552

Published: March 3, 2025

Language: Английский

Citations

0
Recent advances in fluorescent probes for bioimaging lipid droplets associated diseases DOI

Wenli Jiang,

Kexin Du, Jing Zhang

et al.

Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112792 - 112792

Published: March 1, 2025

Language: Английский

Citations

0
Developing a polarity-specialized TICT fluorescent probe for wash-free and long-term monitoring lipid droplets dynamics DOI
Tenghui Wang, Junhui Liu,

Huihui Wei

et al.

Talanta, Journal Year: 2025, Volume and Issue: 294, P. 128191 - 128191

Published: April 19, 2025

Language: Английский

Citations

0
A novel FRET-based fluorescent probe capable of simultaneously imaging lipid droplets and the endoplasmic reticulum with two distinct fluorescence signals in HeLa cells DOI
Tianzhen Liu,

Xiao-Hui Chi,

Bing-Yu Wei

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: unknown, P. 126262 - 126262

Published: April 1, 2025

Language: Английский

Citations

0
Rational design of an AIEgen for imaging lipid droplets polarity change during ferroptosis DOI
Qianqian Zhang, Kunyu Zhao,

Xiaohong Tang

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 321, P. 124701 - 124701

Published: June 19, 2024

Language: Английский

Citations

3