Oxazol‐Fused Phenalenones: Tuning Fluorescence and Singlet Oxygen Generation with Solvent and Substituent

Chemistry - An Asian Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Typically, singlet oxygen is generated by photosensitization, with 1 H ‐phenalen‐1‐one ( PN ) being an efficient photosensitizer that achieves nearly unity quantum yield across various solvents. However, the molecule lacks ability to fluoresce, which could otherwise provide spatiotemporal information for potential theranostic applications. Moreover, its absorption spectrum should be red‐shifted move toward visible range, ideally approaching therapeutic window without compromising generate oxygen. We resolved explore option of fusing new aromatic rings tricyclic structure. A series 9‐substituted 7H ‐phenaleno[2,1‐ d ]oxazol‐7‐one were synthesized and characterized. The results indicate introduction oxazole ring does not significantly disturb photosensitization core ‐phenalen‐1‐one, as evidenced 9‐methyl‐ ]oxazol‐7‐one) presented Φ Δ near solvents; albeit it lacked fluorescence. In contrast, derivatives exhibit a balanced behavior between fluorescence photosensitization. polar protic media, preferred, while in apolar favored. substituent effect was analyzed electron‐donating groups favoring non‐radiative processes, particularly media. Electron‐attracting/neutral exhibited mixed fluorescence, intersystem crossing (ISC), processes. Theoretical calculations suggest observed excitation profiles photochemical correlates electron density remotion from core.

Language: Английский

Synthesis, characterization, structural studies and Hirshfeld surface analysis of Re(III) and Re(V) complexes with picolinohydrazone ligands

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142614 - 142614

Published: May 1, 2025

Language: Английский

Research Progress of Endoplasmic Reticulum Targeting Metal Complexes in Cancer Therapy

Drug Development Research, Journal Year: 2024, Volume and Issue: 85(8)

Published: Dec. 1, 2024

ABSTRACT The development of anticancer drugs that target different organelles has received extensive attention due to the characteristics cancer recurrence, metastasis, and drug resistance. endoplasmic reticulum (ER) is an important structure within cell primarily responsible for protein synthesis, folding, modification, transport plays a crucial role in function health. ER stress activation induces apoptosis. New with mechanisms selectivity can be designed because redox activity, composition diversity, metal complexes regulation. Over past few decades, dozens have killed cells through stress, showing powerful tumor‐suppressive effects. This review summarizes progress research on metallic induce over years, which expected bring more breakthroughs field medicine life science.

Language: Английский