Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 26, 2024
Abstract
The
availability
of
second
near‐infrared
(NIR‐II)
excitable
two‐photon
photosensitizers
with
NIR‐I
emission
for
efficient
photodynamic
therapy
(PDT)
is
limited
by
challenges
in
molecular
design.
In
this
study,
a
NIR‐II
light‐excitable
conjugated
microporous
polymer
(
Tph‐Dbd
)
the
region
developed.
large
system
and
delocalized
electronic
structures
endow
absorption
cross‐section
under
light
excitation.
Moreover,
electron
acceptor
donor
units
within
π‐conjugated
backbones
result
high
signal‐to‐background
ratio
imaging,
as
well
separated
highest
occupied
orbital
lowest
unoccupied
distributions
excellent
singlet
oxygen
generation
ability.
activity,
emission,
good
biocompatibility,
photostability
allow
to
be
used
vitro
fluorescence
imaging
guided
PDT.
impressive
photothermal
effect
can
overcome
limitations
PDT
treatment
hypoxic
tumors.
This
study
highlights
strategy
designing
advanced
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 14, 2025
Abstract
Tuning
the
oxidative
stress‐defense
system
plays
a
vital
role
in
treatment
of
breast
tumors.
In
this
study,
pyropheophorbide‐a
(PPa)‐based
prodrug
nanoassembly
is
constructed
by
linking
PPa
with
furoxan,
cysteine‐depleting
nitric
oxide
(NO)
donor,
through
disulfide
bond.
The
as‐prepared
(NOSP)
can
assemble
distearoyl
phosphoethanolamine‐PEG
2000
(DSPE‐PEG
)
to
form
nanoassemblies
aqueous
media.
Following
internalization
tumor
cells,
NOSP
respond
cysteine
(Cys)
and
induce
NO
release
activate
endogenous
matrix
metalloproteinases
(MMP‐1,
‐2),
leading
collagen
degradation
improved
drug
delivery.
addition,
Cys
consumption
impede
biosynthesis
glutathione
(GSH),
while
react
high
levels
intracellular
GSH
within
seconds,
thus
synergizing
photodynamic
therapy
against
tumors
distant
metastasis.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(6), P. 1274 - 1274
Published: March 12, 2025
The
smart
construction
of
nano-photosensitizers
(PSs)
is
significant
for
multipurpose
applications,
such
as
bioimaging,
efficient
photodynamic
anti-tumor
or
anti-bacterial
studies.
This
work
reports
a
flexible
self-assembling
strategy
the
nano-PSs,
in
which
PSs
spontaneously
form
amorphous
aggregates
killing
bacteria,
self-assemble
with
tetraphenylethene
(TPE)
based
glycoclusters
(TPE-Glc4)
to
construct
glyco-dots
cell
imaging
and
Tricyanofuran
(TCF)
TPE
units
were
bridged
furan
thiophene
moiety
two
(1
2)
NIR
fluorescence
monomers,
performance
aggregation-induced
generation
reactive
oxygen
species
(AIG-ROS)
an
aggregated
state.
Compared
large
(2-a),
TPE-based
encapsulated
PS
(2-Glc)
that
exhibit
smaller
more
homogeneous
hydrated
size
approximately
40
nm,
well
enhanced
water-solubility
biocompatibility.
TPE-glycoclusters
facilitate
cellular
uptake
2
into
HepG2
cells,
therefore
enhancing
signal
therapy.
Meanwhile,
2-a
exhibits
satisfied
phototoxicity
against
Escherichia
coli.
highlights
self-assembly
nano-PSs
multifunctional
bioapplications.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 4, 2024
Bacterial
infections
and
antibiotic
resistance
are
global
health
problems,
current
treatments
for
bacterial
still
rely
on
the
use
of
antibiotics.
Phototherapy
based
a
photosensitizer
has
high
efficiency,
broad
spectrum,
strong
selectivity,
does
not
easily
induce
drug
resistance,
is
expected
to
become
an
effective
strategy
treatment
infections,
particularly
drug-resistant
infections.
This
article
reviews
antimicrobial
strategies
phototherapy
photosensitizers,
including
photodynamic
therapy
(PDT),
photothermal
(PTT),
their
combination.
These
methods
have
significant
application
potential
in
combating
multi-drug-resistant
biofilm
providing
alternative
traditional
antibiotics
chemical
antibacterial
agents.
