Silver N-Heterocyclic Carbene (NHC) Complexes as Antimicrobial and/or Anticancer Agents DOI Creative Commons
Jessica Ceramella, Alessia Catalano, Annaluisa Mariconda

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 18(1), P. 9 - 9

Published: Dec. 25, 2024

The strict connections/interactions between microbial infections and cancer are nowadays widely accepted. Hence, the dual (or multiple) targeting of is an essential issue to be addressed. In this context, metal complexes have gained considerable importance effectiveness in medicinal chemistry. Particularly, N-heterocyclic carbene (NHC) with transition metals emerged as very promising compounds. Among myriad NHC–metal complexes, those bearing silver will subject review. Numerous Ag(I)-NHC revealed high antibacterial and/or anticancer properties, even higher than reference drugs. Herein, we summarize most recent studies while also discussing proposed mechanism action offering interesting remark about research field. Literature databases (PubMed/MEDLINE, Scopus, Google Scholar) were used sources search literature, referring last five years.

Language: Английский

Potent drug candidature of copper-coordinated metallodrug: Experimental study, spectroscopic insights, anticancer activity, apoptosis analysis, cell cycle, theoretical calculations, and molecular docking studies DOI
R. Fouad, Tarik E. Ali, Mohammed A. Assiri

et al.

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: unknown, P. 113187 - 113187

Published: Sept. 1, 2024

Language: Английский

Citations

0
Structure-base design to explore the anticancer efficacy of organometallic Pt(II)- and Au(III)-N-heterocyclic carbene (NHC) complexes DOI
Pooja Das,

Sraddhya Roy,

Chaitali Das

et al.

New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 48(37), P. 16189 - 16201

Published: Jan. 1, 2024

The promising anticancer activities of Pt( ii )- and Au( iii )-N-heterocyclic carbene complexes against triple negative MDA-MB-231 cell line are described.

Language: Английский

Citations

0
Synthesis and Electrochemical Study of Gold(I) Carbene Complexes DOI Creative Commons
Andrea Rodríguez-Rubio,

Álvaro Yuste,

Tomás Torroba

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(17), P. 4081 - 4081

Published: Aug. 28, 2024

In this work, we have prepared and characterized some gold compounds wearing a N-heterocyclic carbene (NHC) ligand as well alkynyl derivatives with different substituents. The study of their electrochemical behavior reveals that these complexes show an irreversible wave at potentials ranging between −2.79 −2.91 V, referenced to the ferrocenium/ferrocene pair. DFT calculations indicate reduction occurs mainly on aryl−C≡C fragment. cyclic voltammetry experiments under CO2 atmosphere increase in faradaic current compared argon atmosphere, indicating possible catalytic activity towards carbon dioxide reaction (CO2RR).

Language: Английский

Citations

0
Chiral Self‐Assembly of Twisted Prisms, Cuboids, and Polyhedral Capped Cages with Tartrate Ligands DOI

Qiu‐Shui Mu,

Xinyu Wang, Xiang Gao

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 6, 2024

Abstract Homochiral triangular prisms, cuboid cages, and capped polyhedral cages are successfully synthesized via coordination‐driven self‐assembly. Typical tartrate ligands demonstrated notable torsional flexibility variable coordination numbers, allowing for diverse patterns, including saturated chelation terminal mono‐coordination with half‐sandwich rhodium iridium fragments. The ligand lengths, molar ratios, metal vertices meticulously designed fine‐tuned to yield chiral entirely distinct architectures. Tartrate exhibits abundant hydrogen bonding interactions induction capabilities, these supramolecular assemblies characterized by single‐crystal X‐ray diffraction, nuclear magnetic resonance, circular dichroism spectroscopy. An efficient method is developed constructing structurally versatile cage‐like entities, facilitating self‐assembly in complicated multi‐component systems.

Language: Английский

Citations

0
UiO-67 MOF-Encapsulated NHC-Based Single-Site Copper Catalyst and Its Application in Regioselective Borylation of Terminal Alkynes DOI
Vijay Mandal,

Kumar Gaurav,

Sandeep H. Kaulage

et al.

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 63(43), P. 20510 - 20520

Published: Oct. 19, 2024

N-Heterocyclic carbenes (NHCs) act as versatile ligand backbones due to their strong σ-donation and π-acceptance properties. However, the encapsulation of NHC-coinage metal complexes in a metal-organic framework (MOF) utilize them organic catalysis is rare. In this work, an NHC-coordinated CuBr (NHC = Bn

Language: Английский

Citations

0
Silver N-Heterocyclic Carbene (NHC) Complexes as Antimicrobial and/or Anticancer Agents DOI Creative Commons
Jessica Ceramella, Alessia Catalano, Annaluisa Mariconda

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 18(1), P. 9 - 9

Published: Dec. 25, 2024

The strict connections/interactions between microbial infections and cancer are nowadays widely accepted. Hence, the dual (or multiple) targeting of is an essential issue to be addressed. In this context, metal complexes have gained considerable importance effectiveness in medicinal chemistry. Particularly, N-heterocyclic carbene (NHC) with transition metals emerged as very promising compounds. Among myriad NHC–metal complexes, those bearing silver will subject review. Numerous Ag(I)-NHC revealed high antibacterial and/or anticancer properties, even higher than reference drugs. Herein, we summarize most recent studies while also discussing proposed mechanism action offering interesting remark about research field. Literature databases (PubMed/MEDLINE, Scopus, Google Scholar) were used sources search literature, referring last five years.

Language: Английский

Citations

0