Partitioning / self‐assembly of artificial water channels ‐ toward controlled permselectivity through bilayer membrane DOI Creative Commons
Dandan Su,

Arie van der Lee,

Mihail Bãrboiu

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 137(1)

Published: Sept. 20, 2024

Abstract Artificial water channels (AWCs) have been extensively explored to mimic natural proteins, which enables effectively transport while blocking ions. As one of the first AWCs, self‐assembled I‐quartets (HCx) showcased high water‐permselectivity that can be enhanced by improving their distribution and stability within membrane. The use long alkyl chains ( n >8) is constrained low solubility aggregation. Herein, we considered cycloalkyl moieties, for increase favoring partition and/ self‐assembly behaviors resulting formation effective stable water‐channels with increased permeability in bilayer membranes. This class cycloalkyl‐ureido‐ethyl‐imidazole amphiphilic (CxUH) channel could serve as a new reference design artificial channels, it may give rise applications desalination or treatment.

Language: Английский

The Role of Hydrogen Bond Interactions in Crystal Formation of Pyrrolo-Azines Alcohols DOI Creative Commons
Marcel Mirel Popa, Mihai Răducă, Isabela C. Man

et al.

Crystals, Journal Year: 2025, Volume and Issue: 15(1), P. 78 - 78

Published: Jan. 15, 2025

New secondary alcohols of type Ar-CHOH-hetaryl and MeCHOH-hetaryl, the radical hetaryl being a pyrroloazine, were investigated in solid state by X-ray single-crystal diffraction analysis, Hirshfeld analysis DFT methods to assess their crystallographic features. One most important features is presence hydroxyl group bonded an asymmetric carbon atom which was involved strong hydrogen bonds. The driving force crystal packing H-bond with O-H···O=C/N≡C bonds considered as comparative carboxylic acids. These structural properties binding affinity might lead enhanced bioavailability these particular pyrrolo-azines

Language: Английский

Citations

1
Designing Highly Ordered Helical and Nonhelical Porous Crystalline and Disordered Nonhelical Columnar Liquid Crystalline Self-Organizations DOI
Dipankar Sahoo, Mihai Peterca, Virgil Percec

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(33), P. 22943 - 22949

Published: Aug. 8, 2024

Helical self-organizations are equilibrium structures responsible for the assembly of nonequilibrium and living synthetic systems. Racemic helical columnar systems transform into one-handed with help enantiomerically rich or pure components. Racemic, rich, periodic arrays columns analyzed by oriented fiber X-ray diffraction (XRD). With few exceptions, highly ordered 3-D organizations as generated from homochiral cannot be obtained achiral, racemic, columns. Here, we report an unprecedented class nonhelical porous ordered, disordered liquid crystalline (LC) liquids constructed AB

Language: Английский

Citations

7
Water-Mediated Chiral Resolution of Ag–NHC(Nucleobase) Complexes DOI
Alvaro Polo, Ricardo Rodrı́guez, Ramón Macı́as

et al.

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

This study reveals a novel role of water as chiral inducer, demonstrating its ability to drive the asymmetric resolution prochiral silver-nucleobase complexes. During crystallization, helical columns spontaneously form, selectively recognizing one enantiomer silver complex. enantiospecific interaction drives separation P and M enantiomers, leading formation enantiopure crystals, whose chirality was confirmed through X-ray crystallography.

Language: Английский

Citations

0
Quantum Health Accelerator® Ameliorates CFA-Induced Animal Model of Rheumatoid Arthritis: Investigating the Role of Immunomodulatory and Anti-Oxidative Effects DOI Creative Commons

Ali Akbar Mohaddes,

Mohammad Saatchi,

Marziyeh Afshari Chamanabadi

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 232 - 232

Published: Feb. 23, 2025

Introduction: Rheumatoid arthritis (RA) is a systemic inflammatory and autoimmune disease characterized by joint swelling, pain, damage to the cartilage, disability. In present study, we aimed evaluate anti-oxidant, anti-inflammatory, immune-modulatory properties of Quantum Health Accelerator® as water enriched with vital bio-quantum information/energy (EW) following complete Freund’s adjuvant (CFA)-induced RA in rats. Methods: Forty adult male Wistar rats (180–220 g) were divided into five groups. Arthritis was induced on day one using single subcutaneous injection CFA left hind footpad rat. Rats assigned receive methotrexate (MTX, 2 mg/kg/week, intraperitoneally), EW (orally, instead normal ad libitum), or their combination for 29 days. The anti-RA activities determined paw edema, diameter, score, several nociceptive behavioral tests (thermal hyperalgesia, cold allodynia, tactile allodynia). levels (TNF-α, CRP, RF, anti-CCP), anti-inflammatory (IL-10), oxidative stress (NO, MDA, GSH) markers measured serum. addition, IFN-γ, IL-4, IL-17, TGF-β assessed spleen-isolated lymphocytes. Results: We found that treatment MTX, EW, remarkably ameliorated thermal allodynia results CFA-induced also notably attenuated cytokines, while propagating anti-oxidative mediators. Conclusions: reveal possesses anti-arthritic effects, possibly through anti-oxidative, immunomodulatory properties. Collectively, may be promising therapeutic agent treating RA.

Language: Английский

Citations

0
Porous Helical Supramolecular Columns Self-Organized via the Fluorophobic Effect of a Semifluorinated Tapered Dendron DOI Creative Commons
Dipankar Sahoo, Mihai Peterca, Mohammad R. Imam

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Fluorophobic effect enhances supramolecular microsegregation.

Language: Английский

Citations

2
Partitioning / self‐assembly of artificial water channels ‐ toward controlled permselectivity through bilayer membrane DOI Creative Commons
Dandan Su,

Arie van der Lee,

Mihail Bãrboiu

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 64(1)

Published: Sept. 20, 2024

Artificial water channels (AWCs) have been extensively explored to mimic natural proteins, which enables effectively transport while blocking ions. As one of the first AWCs, self-assembled I-quartets (HCx) showcased high water-permselectivity that can be enhanced by improving their distribution and stability within membrane. The use long alkyl chains (n>8) is constrained low solubility aggregation. Herein, we considered cycloalkyl moieties, for increase favoring partition and/ self-assembly behaviors resulting formation effective stable water-channels with increased permeability in bilayer membranes. This class cycloalkyl-ureido-ethyl-imidazole amphiphilic (CxUH) channel could serve as a new reference design artificial channels, it may give rise applications desalination or treatment.

Language: Английский

Citations

0
Partitioning / self‐assembly of artificial water channels ‐ toward controlled permselectivity through bilayer membrane DOI Creative Commons
Dandan Su,

Arie van der Lee,

Mihail Bãrboiu

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 137(1)

Published: Sept. 20, 2024

Abstract Artificial water channels (AWCs) have been extensively explored to mimic natural proteins, which enables effectively transport while blocking ions. As one of the first AWCs, self‐assembled I‐quartets (HCx) showcased high water‐permselectivity that can be enhanced by improving their distribution and stability within membrane. The use long alkyl chains ( n >8) is constrained low solubility aggregation. Herein, we considered cycloalkyl moieties, for increase favoring partition and/ self‐assembly behaviors resulting formation effective stable water‐channels with increased permeability in bilayer membranes. This class cycloalkyl‐ureido‐ethyl‐imidazole amphiphilic (CxUH) channel could serve as a new reference design artificial channels, it may give rise applications desalination or treatment.

Language: Английский

Citations

0