Near‐Infrared Bioimaging Using Two‐photon Fluorescent Probes DOI

Pragti Pragti,

Bidyut Kumar Kundu, Rui Chen

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Abstract Near‐infrared (NIR) bioimaging has emerged as a transformative technology in biomedical research. Among many fluorescent probes that are suitable for NIR imaging studies, two‐photon absorption (TPA) ones represent particularly promising category, because TPA can overcome the inherent limitations of one‐photon (OPA) counterparts. By leveraging unique properties absorption, achieve superior tissue penetration, significantly reduced photodamage, and enhanced spatial resolution. This perspective article delves into fundamental principles, design strategies, representative various applications. In particular, number molecular probes, ranging from organic, inorganic, COF/MOF‐based systems highlighted to showcase vast scope possible probe application scenarios. addition, employment stimulated responsive different external factors, including pH, redox species, enzymes, hypoxia, is also discussed. end, future perspectives continuous advancement field presented. For instance, it essential transition cellular vivo studies obtain more physiologically relevant insights. Additionally, development “dual‐function” both disease diagnosis therapeutic treatment promising.

Language: Английский

Vertically aligned mesoporous silica films bearing covalently bound tris(2,2’-bipyridyl)ruthenium(II) redox photocatalysts DOI Creative Commons

Mahmoud Rahal,

Cheryl Karman, Neus Vilà

et al.

Microporous and Mesoporous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 113524 - 113524

Published: Jan. 1, 2025

Language: Английский

Citations

1
Advances in the Design of Photoactivatable Metallodrugs: Excited State Metallomics DOI Creative Commons
Huayun Shi, Rafael C. Marchi, Peter J. Sadler

et al.

Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Photoactivatable metal complexes offer the prospect of novel drugs with low side effects and new mechanisms action to combat resistance current therapy. We highlight recent progress in design platinum, ruthenium, iridium, gold other transition complexes, especially for applications as anticancer anti‐infective agents. In particular, understanding excited state chemistry related identification bioactive species (excited metallomics/pharmacophores) is important. metallodrugs are classified here photocatalysts, photorelease agents ligand‐activated Their activation wavelengths, cellular action, experimental theoretical metallomics states photoproducts discussed explore strategies investigation photoactivatable metallodrugs. These have potential clinical Photodynamic Therapy (PDT), Photoactivated Chemotherapy (PACT) Photothermal (PTT).

Language: Английский

Citations

0
Advances in the Design of Photoactivatable Metallodrugs: Excited State Metallomics DOI Creative Commons
Huayun Shi, Rafael C. Marchi, Peter J. Sadler

et al.

Angewandte Chemie, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Photoactivatable metal complexes offer the prospect of novel drugs with low side effects and new mechanisms action to combat resistance current therapy. We highlight recent progress in design platinum, ruthenium, iridium, gold other transition complexes, especially for applications as anticancer anti‐infective agents. In particular, understanding excited state chemistry related identification bioactive species (excited metallomics/pharmacophores) is important. metallodrugs are classified here photocatalysts, photorelease agents ligand‐activated Their activation wavelengths, cellular action, experimental theoretical metallomics states photoproducts discussed explore strategies investigation photoactivatable metallodrugs. These have potential clinical Photodynamic Therapy (PDT), Photoactivated Chemotherapy (PACT) Photothermal (PTT).

Language: Английский

Citations

0
Red light excitation: illuminating photocatalysis in a new spectrum DOI Creative Commons

Lucas Fortier,

Corentin Lefebvre, Norbert Hoffmann

et al.

Beilstein Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 21, P. 296 - 326

Published: Feb. 7, 2025

Red-light-activated photocatalysis has become a powerful approach for achieving sustainable chemical transformations, combining high efficiency with energy-saving, mild conditions. By harnessing the deeper penetration and selectivity of red near-infrared light, this method minimizes side reactions typical higher-energy sources, making it particularly suited large-scale applications. Recent advances highlight unique advantages both metal-based metal-free catalysts under red-light irradiation, broadening range possible reactions, from selective oxidations to complex polymerizations. In biological contexts, enables innovative applications in phototherapy controlled drug release, exploiting its tissue low cytotoxicity. Together, these developments underscore versatility impact photocatalysis, positioning as cornerstone green organic chemistry significant potential synthetic biomedical fields.

Language: Английский

Citations

0
Molecular engineering and electrolyte optimization strategies for enhanced performance of Ru(ii) polypyridyl-sensitized DSSCs DOI Creative Commons
Islam M. Abdellah

RSC Advances, Journal Year: 2025, Volume and Issue: 15(13), P. 9763 - 9786

Published: Jan. 1, 2025

This review highlights the advantages of optimizing various DSSC components, such as Ru( ii )-polypyridyl photosensitizers, co-adsorbents, electrolytes, electrolyte additives, and counter electrodes, to improve overall performance DSSCs.

Language: Английский

Citations

0
Inverse Opal Torus‐Shaped Photonic Microobjects with Superior Stimulus‐Responsive Properties to Their Spherical Equivalents DOI
Xiaoyang Du,

Shuchen Zhang,

Junqi Zhou

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Abstract Because of their many uses and simplicity manufacture, colloidal photonic microobjects made from droplet templates have been the subject extensive research. Owing to low interfacial energy, majority are spherical, however nonspherical forms, such as torus‐shaped (TSPMs) also seen. Although there reports TSPMs based on various building blocks, usual lack stimulus‐responsive qualities restricts potential uses. In this work, hydrogel‐based inverse opal (IO‐TSPMs) that sensitive alcohol pH created. IO‐TSPMs react more quickly than spherical ones produced by first creating opal‐structured TSPMs, then infiltrating monomers, polymerizing under UV light, etching, visibly illustrate difference. Unlike structures, which only provide unidirectional stimulus propagation, torus structures allow stimulation bidirectionally propagate both inner outer borders. Potential applications for these include biomimetic materials, quick diagnostic inspection tools, blocks innovative patterns.

Language: Английский

Citations

0
Near‐Infrared Bioimaging Using Two‐photon Fluorescent Probes DOI

Pragti Pragti,

Bidyut Kumar Kundu, Rui Chen

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Abstract Near‐infrared (NIR) bioimaging has emerged as a transformative technology in biomedical research. Among many fluorescent probes that are suitable for NIR imaging studies, two‐photon absorption (TPA) ones represent particularly promising category, because TPA can overcome the inherent limitations of one‐photon (OPA) counterparts. By leveraging unique properties absorption, achieve superior tissue penetration, significantly reduced photodamage, and enhanced spatial resolution. This perspective article delves into fundamental principles, design strategies, representative various applications. In particular, number molecular probes, ranging from organic, inorganic, COF/MOF‐based systems highlighted to showcase vast scope possible probe application scenarios. addition, employment stimulated responsive different external factors, including pH, redox species, enzymes, hypoxia, is also discussed. end, future perspectives continuous advancement field presented. For instance, it essential transition cellular vivo studies obtain more physiologically relevant insights. Additionally, development “dual‐function” both disease diagnosis therapeutic treatment promising.

Language: Английский

Citations

2