ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(22), P. 25603 - 25618
Published: Nov. 8, 2024
Cancer
phototheranostics
is
a
new
mode
of
precise
treatment
based
on
fluorescent
and
photothermal
imaging
(PTI),
combined
with
photodynamic
(PDT)
therapy
(PTT).
Herein,
we
designed
photoactive
Pt(IV)
prodrug
Pt-1
BODIPY-based
triplet
photosensitizer
as
an
axial
ligand
that
exhibits
cytotoxic
effects
through
both
PDT
photoactivated
chemotherapy
(PACT).
Based
the
prodrug,
developed
multifunctional
theranostic
nanoplatform
Pt-NPs
PDT/PTT
activity,
capable
light-induced
cisplatin
release
suitable
for
tumor
imaging.
Upon
660
nm
laser
irradiation,
efficiently
causes
regional
hyperpyrexia,
conversion
efficiency
42.1%.
Synergistically,
acts
type
I
agent.
In
vivo
PTI
studies
have
shown
bright
fluorescence
CT-26
after
intravenous
injection
Pt-NPs,
indicating
accumulation
retention
in
tumor.
This
first
example
PTT/PDT-active
NPs
photoinduced
cisplatin.
strategy
synergistic
PDT/PTT/PACT
action
provides
platform
future
design
phototheranostic
agents
enhanced
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(43), P. 58920 - 58930
Published: Oct. 17, 2024
Nanothermometers
can
detect
changes
in
the
local
temperature
living
cells
and
vivo,
revealing
fundamental
biological
properties.
Despite
exploration
of
different
temperature-responsive
materials,
design
development
temperature-sensing
probes
with
high
brightness
sensitivity
remain
a
daunting
challenge.
Here,
we
employed
UiO-66
type
metal-organic
frameworks
(MOFs)
to
anchor
UNCPs
on
surface
MOFs
for
constructing
MOF@UCNPs
nanohybrids.
The
situ
composite
method
leads
coordination
interaction
between
ligands
UCNPs,
enabling
controlled
formation
UCNPs.
Remarkably,
favors
anomalous
thermo-enhanced
luminescence,
achieving
35-fold
enhancement
UiO-66@NaYF4:Yb/Tm
at
413
K.
Furthermore,
these
nanohybrids
luminescence
are
developed
as
multifunctional
bioimaging
intracellular
sensing,
demonstrating
thermal
1.92%
K-1
physiological
range.
Based
findings,
monitoring
position
was
successfully
carried
out
by
designed
nanoprobes
vivo.
These
findings
underscore
potential
nanohybrids,
opening
up
new
avenues
platform
analysis.
Journal of Medicinal Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
Photodynamic
therapy
(PDT)
offers
minimally
invasive
and
repeatable
cancer
treatment
options.
Despite
advancements
in
photosensitizer
(PS)
design,
the
optical
control
of
PS
activation
remains
unexplored.
Here,
we
present
first
photoswitchable
based
on
a
BOAHY-BODIPY
dyad
system.
Inspired
by
BODIPY
multimer
structures
BOAHY's
photoisomerization
properties,
designed
mono-(4
series)
bis-BOAHY-BODIPY
(5
conjugates.
These
dyads
primarily
generate
reactive
oxygen
species
via
type-I
process
under
white
light.
Notably,
4
series
compounds
demonstrated
effective
photocytotoxicity
photoswitching
properties
vitro.
Building
these,
iodinated
monoconjugates
to
develop
highly
efficient
PS,
6b,
which
exhibited
enhanced
intersystem
crossing
type-II
generation
due
reduced
singlet-triplet
energy
gap.
As
demonstration
PDT
agents,
this
strategy
introduces
new
approach
with
significant
potential
for
selective
clinical
applications.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 22, 2025
Cell
penetrating
peptides
(CPPs)
are
usually
positive
charged
and
have
good
cell
membrane
permeability.
Meanwhile,
CPPs
facile
to
synthesize,
can
be
functionalized
satisfy
different
demands,
such
as
cyclization,
incorporating
unnatural
amino
acids,
lipid
conjugation.
These
properties
made
them
efficient
drug-delivery
tools
deliver
therapeutic
molecules
cells
tissues
in
a
nontoxic
manner,
including
small
molecules,
DNA,
siRNA,
proteins
other
various
nanoparticles.
However,
the
poor
serum
stability
low
tumor
targeting
ability
also
hindered
their
broad
application.
Besides,
inappropriate
chemical
modification
lead
disruption
nonspecific
toxicity.
In
this
paper,
we
first
reviewed
recent
advances
CPP
applications
for
cancer
therapy
via
covalent
or
non-covalent
manners.
We
carefully
analyzed
advantages
disadvantages
of
each
modifications
drug
delivery.
Then,
concluded
progress
clinical
trials
diseases.
Finally,
discussed
challenges
opportunities
met
translate
into
applications.
This
review
presented
new
insight
delivery,
which
could
provide
advice
on
design
clinically
effective
systemic
delivery
systems
using
CPPs.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 23, 2025
Abstract
Type
I
photosensitization
is
of
particular
significance
in
the
anaerobic
tumor
treatment.
Nonetheless,
development
high‐performance
type
photosensitizers
(PSs)
remains
challenging,
due
to
weak
absorption
and
inefficient
intersystem
crossing
(ISC)
progress.
Herein,
an
effective
approach
toward
a
near‐infrared
(NIR)
PS
(
NIR‐BN
)
demonstrated
using
boron/nitrogen‐embedded
polycyclic
aromatic
hydrocarbon
with
multiple‐resonance
(MR)
character,
for
first
time.
A
small
singlet‐triplet
splitting
(Δ
E
ST
=
0.09
eV)
high
molar
extinction
coefficient
(3.3
×
10
4
M
−1
cm
NIR
MR‐configured
supports
efficient
ISC
triplet
sensitization.
The
distorted
molecular
configurations
induce
multi‐model
structural
relaxations
after
optical
excitation,
resulting
remarkable
photothermal
conversion
efficiency
exceeding
50%
nanoparticles.
Of
note,
nanoparticles
are
capable
generating
highly
toxic
superoxide
anion
radical
(O
2
•−
under
660
nm
laser
irradiation,
benefiting
from
vigorous
intramolecular
dihedral
angle
vibrations
excited
states.
Consequently,
biocompatible
demonstrates
superior
performance
vivo
synergistic
photodynamic
therapies.
Nano Letters,
Journal Year:
2025,
Volume and Issue:
25(11), P. 4576 - 4585
Published: March 10, 2025
Xenotransplantation
offers
a
transformative
solution
to
the
global
organ
shortage
crisis.
However,
survival
of
xenografts
remains
limited
despite
various
proposed
strategies.
In
this
study,
we
present
an
endothelial
cell
protection
strategy
that
extends
graft
through
in
situ
construction
biomimetic
glycan-enriched
nanofibers.
These
molecules
specifically
target
integrin
αvβ3
and
form
polysaccharide-structured
nanofiber
network
on
vascular
surface.
This
protects
cells
without
compromising
their
normal
physiological
functions.
The
constructed
layer
significantly
increased
xenograft
by
1.64-fold
compared
untreated
groups.
work
introduces
novel
enhance
heart
xenografts.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 29, 2025
Abstract
Organic
co‐crystal
engineering
offers
a
convenient
and
efficient
platform
for
preparing
photothermal
conversion
(PTC)
materials.
However,
current
donor–acceptor
(D–A)
co‐crystals
generally
have
medium
performance.
Here,
an
inclusion
strategy
is
presented,
i.e.,
host–guest
encapsulation
of
small
acceptor
inside
donor‐type
macrocycle's
cavity,
to
enhance
PTC
efficiency
through
the
promotion
D–A
binding.
A
naphthyl‐sidewall
Tröger's
base
(TB[2])
molecular
box
donor
elaborately
designed,
which
can
encapsulate
electron‐deficient
7,7,8,8‐tetracyanoquinodimethane
(TCNQ)
form
1:2
ternary
charge‐transfer
(CT)
via
synergism
multiple
noncovalent
forces.
Under
808
nm
laser
irradiation
(0.7
W
cm
−2
),
as
high
94.3%.
The
are
further
introduced
into
porous
polymer
polyurethane
(PU)
prepare
interfacial
evaporator
(TB‐TCNQ@PU)
solar‐driven
water
evaporation.
1
Sun
irradiation,
high‐water
evaporation
rate
1.746
kg
m
h
−1
prominent
solar‐to‐vapor
93.8%
achieved.
This
work
opens
new
avenues
