Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 4
Published: Dec. 27, 2024
Language: Английский
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 529, P. 216430 - 216430
Published: Jan. 24, 2025
Language: Английский
Citations
0
annals of urologic oncology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 31, 2025
Prostate cancer is a worldwide health concern in men, with substantially high incidence rate and advanced metastatic disease-related mortality rates. Despite advancements diagnostics treatment options, conventional therapies for prostate cancer, including surgery, radiotherapy, chemotherapy androgen deprivation therapy, face limitations such as resistance, limited precision off-target side-effects. Hence, identification clinical translation of novel therapeutic strategies urgently needed. In this regard, phototherapies, photodynamic therapy (PDT) photothermal (PTT), are emerging promising options addressing the challenges associated options. Utilizing near-infrared (NIR) light to selectively target cells, these approaches spare healthy tissues. PDT employs photosensitizers produce reactive oxygen species, thereby stimulating anti-tumor immune responses, disrupting tumor microvasculature and/or inducing aopotitic or necrotic cell death. contrast, PTT leverages agents generate localized hyperthermia, achieving effective thermal ablation cells. Recent nanoparticle technology have significantly improved efficacy specificity phototherapies. Functionalized nanoparticles, those targeting prostate-specific membrane antigen (PSMA), enhance delivery, reducing systemic toxicity. Combination incorporating modalities, immunotherapy, demonstrated synergistic effects, leading better sensitization. Preclinical studies underline potential multimodal outcomes, particularly castration-resistant cancer. This review explores recent innovations illuminating their combination therapies, global burden.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of Microencapsulation, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 34
Published: March 20, 2025
Female reproductive cancers, including ovarian, cervical, breast, gestational trophoblastic and endometrial cancer, present significant challenges in therapy patient prognosis. Conventional chemotherapy often lacks selectivity, leading to systemic toxicity reduced treatment efficacy. Nanotechnology has emerged as a promising approach improve drug delivery therapeutic outcomes. Encapsulation of FDA-approved drugs within nanocarriers such liposomes, polymeric nanoparticles, lipid nanoparticles enables controlled release, reduces off-target effects, enhances accumulation at tumor sites. This targeted minimizes damage healthy tissues improves survival rates. Additionally, nanoformulations facilitate combination therapy, overcoming resistance maximizing Despite results, like scalability, reproducibility, regulatory approvals hinder widespread clinical applications. Developing personalized tailored individual profiles offers potential for precision cancer therapy. study explores the role enhancing treating female cancers.
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: March 28, 2025
Currently, immunotherapy based on photothermal and the application of photodynamic therapy in anti-tumor treatment is showing great potential. Its uniqueness lies critical role small molecule immunomodulators promoting effective immune responses against tumors, use laser-activated biophysical mechanisms to precisely trigger swift demise cancer cells, avoiding damage surrounding normal tissues. However, (PDT) alone hampered by tumors' hypoxic environment, resulting poor antitumor effects, while (PTT) cannot arouse enough antigen presentation. It significance design photosensitizers (PSs) that possess both PDT PTT effects. Herein, a series PSs with efficacy are reported, ultimately selecting Cy7-Naph as star due its best overall phototherapeutic effect. Upon reactive oxygen species (ROS) production thermogenesis tumor induced significant apoptosis eventually boosted release damage-associated molecular patterns (DAMPs) under near-infrared (NIR) light irradiation. By combining Toll-like receptor agonist Resiquimod (R848), synergistic for bilateral tumor-bearing mice achieved. This combination promotes dendritic cell (DC) maturation increases infiltration cytotoxic T lymphocytes (CTLs), leading inhibition primary distant tumors.
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113720 - 113720
Published: April 1, 2025
Language: Английский
Citations
0
Science China Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 8, 2025
Language: Английский
Citations
0
Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114729 - 114729
Published: April 1, 2025
Language: Английский
Citations
0
Progress in Materials Science, Journal Year: 2024, Volume and Issue: unknown, P. 101375 - 101375
Published: Sept. 1, 2024
Language: Английский
Citations
1
Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1321, P. 140214 - 140214
Published: Sept. 27, 2024
Language: Английский
Citations
1